Longitudinal profile of circulating endothelial cells in post-acute coronary syndrome patients

Marie de Bakker, Jaco Kraan, K. Martijn Akkerhuis, Rohit Oemrawsingh, Folkert W. Asselbergs, Imo Hoefer, Isabella Kardys, Eric Boersma*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)
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Abstract

Introduction: Patients who have experienced an acute coronary syndrome (ACS) are at risk of a recurrent event, but their level of risk varies. Because of their close temporal relationship with vascular injury, longitudinal measurements of circulating endothelial cells (CECs) carry potential to improve individual risk assessment. Methods: We conducted an explorative nested case-control study within our multicenter, prospective, observational biomarker study (BIOMArCS) of 844 ACS patients. Following an index ACS, high-frequency blood sampling was performed during 1-year follow-up. CECs were identified using flow cytometric analyses in 15 cases with recurrent event, and 30 matched controls. Results: Cases and controls had a median (25th-75thpercentile) age of 64.1 (58.1-75.1) years and 80% were men. During the months preceding the endpoint, the mean (95%CI) CEC concentration in cases was persistently higher than in controls (12.8 [8.2-20.0] versus 10.0 [7.0-14.4] cells/ml), although this difference was non-significant (P = 0.339). In controls, the mean cell concentration was significantly (P = 0.030) lower in post 30-day samples compared to samples collected within one day after index ACS: 10.1 (7.5-13.6) versus 17.0 (10.8-26.6) cells/ml. Similar results were observed for CEC subsets co-expressing CD133 and CD309 (VEGFR-2) or CD106 (VCAM-1). Conclusion: Despite their close relation to vascular damage, no increase in cell concentrations were found prior to the occurrence of a secondary adverse cardiac event.

Original languageEnglish
Pages (from-to)152-159
Number of pages8
JournalBiomarkers
Volume28
Issue number2
Early online date8 Jan 2023
DOIs
Publication statusPublished - 2023

Bibliographical note

Funding Information:
This work was supported by the Dutch Heart Foundation (grant number 2007B012), the Netherlands Heart Institute-Interuniversity Cardiology Institute of the Netherlands (project number 071.01) and the Working Group on Cardiovascular Research Netherlands, all of which are non-commercial funding bodies. An unrestricted research grant was further obtained from Eli Lilly, the Netherlands We are grateful to Mai Van for her excellent technical assistance. Folkert Asselbergs is supported by UCL Hospitals NIHR Biomedical Research Centre.

Funding Information:
We are grateful to Mai Van for her excellent technical assistance. Folkert Asselbergs is supported by UCL Hospitals NIHR Biomedical Research Centre.

Publisher Copyright:
© 2023 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

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