Looking below the surface: Intraoperative assessment of resection margins in oral cancer surgery

Yassine Aaboubout

Looking below the surface: Intraoperative assessment of resection margins in oral cancer surgery

Yassine Aaboubout

Otorhinolaryngology and Head and Neck Surgery

Research output: Types of Thesis › Doctoral Thesis › Internal

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Abstract

Each year, 350,000 patients are diagnosed with oral cavity squamous cell carcinoma (OCSCC). Surgery often fails to achieve adequate margins, with only 15–26% success. Specimen-driven intraoperative assessment of resection margins (IOARM) improves outcomes but is labor-intensive. This thesis presents a Raman spectroscopy–based IOARM device (RIOARM-device) that rapidly measures tumor–margin distance with high accuracy (sensitivity 0.85, specificity 0.92). The RIOARM-device offers a fast, accurate, and widely applicable solution for improving surgical outcomes.

Original language	English
Awarding Institution	Erasmus University Rotterdam
Supervisors/Advisors	Koljenovic, Senada, Supervisor Baatenburg de Jong, Robert Jan, Supervisor Puppels, Gerwin, Co-supervisor
Award date	23 Oct 2025
Place of Publication	Rotterdam
Print ISBNs	978-94-6510-931-2
Publication status	Published - 23 Oct 2025

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final dissertation Aaboubout, YassineFinal published version, 15.4 MB

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title = "Looking below the surface: Intraoperative assessment of resection margins in oral cancer surgery",

abstract = "Each year, 350,000 patients are diagnosed with oral cavity squamous cell carcinoma (OCSCC). Surgery often fails to achieve adequate margins, with only 15–26\% success. Specimen-driven intraoperative assessment of resection margins (IOARM) improves outcomes but is labor-intensive. This thesis presents a Raman spectroscopy–based IOARM device (RIOARM-device) that rapidly measures tumor–margin distance with high accuracy (sensitivity 0.85, specificity 0.92). The RIOARM-device offers a fast, accurate, and widely applicable solution for improving surgical outcomes.",

author = "Yassine Aaboubout",

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TY - BOOK

T1 - Looking below the surface

T2 - Intraoperative assessment of resection margins in oral cancer surgery

AU - Aaboubout, Yassine

PY - 2025/10/23

Y1 - 2025/10/23

N2 - Each year, 350,000 patients are diagnosed with oral cavity squamous cell carcinoma (OCSCC). Surgery often fails to achieve adequate margins, with only 15–26% success. Specimen-driven intraoperative assessment of resection margins (IOARM) improves outcomes but is labor-intensive. This thesis presents a Raman spectroscopy–based IOARM device (RIOARM-device) that rapidly measures tumor–margin distance with high accuracy (sensitivity 0.85, specificity 0.92). The RIOARM-device offers a fast, accurate, and widely applicable solution for improving surgical outcomes.

AB - Each year, 350,000 patients are diagnosed with oral cavity squamous cell carcinoma (OCSCC). Surgery often fails to achieve adequate margins, with only 15–26% success. Specimen-driven intraoperative assessment of resection margins (IOARM) improves outcomes but is labor-intensive. This thesis presents a Raman spectroscopy–based IOARM device (RIOARM-device) that rapidly measures tumor–margin distance with high accuracy (sensitivity 0.85, specificity 0.92). The RIOARM-device offers a fast, accurate, and widely applicable solution for improving surgical outcomes.

M3 - Doctoral Thesis

SN - 978-94-6510-931-2

CY - Rotterdam

ER -

Looking below the surface: Intraoperative assessment of resection margins in oral cancer surgery

Abstract

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