Looking below the surface: Intraoperative assessment of resection margins in oral cancer surgery

Yassine Aaboubout

Looking below the surface: Intraoperative assessment of resection margins in oral cancer surgery

Yassine Aaboubout

Otorhinolaryngology and Head and Neck Surgery

Research output: Types of Thesis › Doctoral Thesis › Internal

242 Downloads (Pure)

Abstract

Each year, 350,000 patients are diagnosed with oral cavity squamous cell carcinoma (OCSCC). Surgery often fails to achieve adequate margins, with only 15–26% success. Specimen-driven intraoperative assessment of resection margins (IOARM) improves outcomes but is labor-intensive. This thesis presents a Raman spectroscopy–based IOARM device (RIOARM-device) that rapidly measures tumor–margin distance with high accuracy (sensitivity 0.85, specificity 0.92). The RIOARM-device offers a fast, accurate, and widely applicable solution for improving surgical outcomes.

Original language	English
Awarding Institution	Erasmus University Rotterdam
Supervisors/Advisors	Koljenovic, Senada, Supervisor Baatenburg de Jong, Robert Jan, Supervisor Puppels, Gerwin, Co-supervisor
Award date	23 Oct 2025
Place of Publication	Rotterdam
Publisher	Erasmus University Rotterdam (EUR)
Print ISBNs	978-94-6510-931-2
Publication status	Published - 23 Oct 2025

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Access to Document

final dissertation Aaboubout, YassineFinal published version, 15.4 MB

Cite this

@phdthesis{6fe59f92388e44ef898d3b5335c0ce6a,

title = "Looking below the surface: Intraoperative assessment of resection margins in oral cancer surgery",

abstract = "Each year, 350,000 patients are diagnosed with oral cavity squamous cell carcinoma (OCSCC). Surgery often fails to achieve adequate margins, with only 15{\textendash}26\% success. Specimen-driven intraoperative assessment of resection margins (IOARM) improves outcomes but is labor-intensive. This thesis presents a Raman spectroscopy{\textendash}based IOARM device (RIOARM-device) that rapidly measures tumor{\textendash}margin distance with high accuracy (sensitivity 0.85, specificity 0.92). The RIOARM-device offers a fast, accurate, and widely applicable solution for improving surgical outcomes.",

author = "Yassine Aaboubout",

year = "2025",

month = oct,

day = "23",

language = "English",

isbn = "978-94-6510-931-2",

publisher = "Erasmus University Rotterdam (EUR)",

school = "Erasmus University Rotterdam",

}

TY - BOOK

T1 - Looking below the surface

T2 - Intraoperative assessment of resection margins in oral cancer surgery

AU - Aaboubout, Yassine

PY - 2025/10/23

Y1 - 2025/10/23

N2 - Each year, 350,000 patients are diagnosed with oral cavity squamous cell carcinoma (OCSCC). Surgery often fails to achieve adequate margins, with only 15–26% success. Specimen-driven intraoperative assessment of resection margins (IOARM) improves outcomes but is labor-intensive. This thesis presents a Raman spectroscopy–based IOARM device (RIOARM-device) that rapidly measures tumor–margin distance with high accuracy (sensitivity 0.85, specificity 0.92). The RIOARM-device offers a fast, accurate, and widely applicable solution for improving surgical outcomes.

AB - Each year, 350,000 patients are diagnosed with oral cavity squamous cell carcinoma (OCSCC). Surgery often fails to achieve adequate margins, with only 15–26% success. Specimen-driven intraoperative assessment of resection margins (IOARM) improves outcomes but is labor-intensive. This thesis presents a Raman spectroscopy–based IOARM device (RIOARM-device) that rapidly measures tumor–margin distance with high accuracy (sensitivity 0.85, specificity 0.92). The RIOARM-device offers a fast, accurate, and widely applicable solution for improving surgical outcomes.

M3 - Doctoral Thesis

SN - 978-94-6510-931-2

PB - Erasmus University Rotterdam (EUR)

CY - Rotterdam

ER -

Looking below the surface: Intraoperative assessment of resection margins in oral cancer surgery

Abstract

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this