Loss of CAMK2G affects intrinsic and motor behavior but has minimal impact on cognitive behavior

Pomme M.F. Rigter, Charlotte de Konink, Geeske M. van Woerden*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)
34 Downloads (Pure)

Abstract

Introduction: The gamma subunit of calcium/calmodulin-dependent protein kinase 2 (CAMK2G) is expressed throughout the brain and is associated with neurodevelopmental disorders. Research on the role of CAMK2G is limited and attributes different functions to specific cell types. Methods: To further expand on the role of CAMK2G in brain functioning, we performed extensive phenotypic characterization of a Camk2g knockout mouse. Results: We found different CAMK2G isoforms that show a distinct spatial expression pattern in the brain. Additionally, based on our behavioral characterization, we conclude that CAMK2G plays a minor role in hippocampus-dependent learning and synaptic plasticity. Rather, we show that CAMK2G is required for motor function and that the loss of CAMK2G results in impaired nest-building and marble burying behavior, which are innate behaviors that are associated with impaired neurodevelopment. Discussion: Taken together, our results provide evidence for a unique function of this specific CAMK2 isozyme in the brain and further support the role of CAMK2G in neurodevelopment.

Original languageEnglish
Article number1086994
JournalFrontiers in Neuroscience
Volume16
DOIs
Publication statusPublished - 6 Jan 2023

Bibliographical note

Funding Information:
This research was supported by the NWO-VIDI (016.Vidi.188.014 to GW).

Publisher Copyright:
Copyright © 2023 Rigter, de Konink and van Woerden.

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