Loss of global DNA hypermethylation is prognostic in IDH-mutant and 1p/19q-codeleted oligodendrogliomas

Felix E. Hinz; Dennis Friedel; Franziska M. Ippen; Martin Sill; Andrey Korshunov; Leonille Schweizer; Daniel Schrimpf; Kirsten Göbel; Lukas S. Friedrich; Fuat K. Aras; Henri Bogumil; Rouzbeh Banan; Hildegard Dohmen; Till Acker; Sebastian Brandner; Simone Schmid; David Capper; Niklas Grassl; Henning B. Boldt; Pieter Wesseling; Sybren L.N. Maas; Juan P.Garces Martinez; Christine Stadelmann; Guido Reifenberger; Thomas Stehle; Alonso Barrantes-Freer; Tareq A. Juratli; Stefan Pusch; Daniel Haag; David E. Reuss; Christel Herold-Mende; Sandro Krieg; Wolfgang Wick; Nima Etminan; Michael Platten; Stefan M. Pfister; David T.W. Jones; Felix Sahm; Andreas von Deimling; Abigail K. Suwala

doi:10.1007/s00401-025-02963-7

Loss of global DNA hypermethylation is prognostic in IDH-mutant and 1p/19q-codeleted oligodendrogliomas

Felix E. Hinz
, Dennis Friedel
, Franziska M. Ippen
, Martin Sill
, Andrey Korshunov
, Leonille Schweizer
, Daniel Schrimpf
, Kirsten Göbel
, Lukas S. Friedrich
, Fuat K. Aras
, Henri Bogumil
, Rouzbeh Banan
, Hildegard Dohmen
, Till Acker
, Sebastian Brandner
, Simone Schmid
, David Capper
, Niklas Grassl
, Henning B. Boldt
, Pieter Wesseling

Sybren L.N. Maas, Juan P.Garces Martinez, Christine Stadelmann, Guido Reifenberger, Thomas Stehle, Alonso Barrantes-Freer, Tareq A. Juratli, Stefan Pusch, Daniel Haag, David E. Reuss, Christel Herold-Mende, Sandro Krieg, Wolfgang Wick, Nima Etminan, Michael Platten, Stefan M. Pfister, David T.W. Jones, Felix Sahm, Andreas von Deimling, Abigail K. Suwala^*

^*Corresponding author for this work

Pathology

Research output: Contribution to journal › Article › Academic › peer-review

Original language	English
Article number	56
Journal	Acta Neuropathologica
Volume	150
Issue number	1
DOIs	https://doi.org/10.1007/s00401-025-02963-7
Publication status	Published - 26 Nov 2025

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Loss of global DNA hypermethylation is prognostic in IDH-mutant and 1p 19q-codeleted oligodendrogliomasFinal published version, 670 KBLicence: CC BY

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Hinz, F. E., Friedel, D., Ippen, F. M., Sill, M., Korshunov, A., Schweizer, L., Schrimpf, D., Göbel, K., Friedrich, L. S., Aras, F. K., Bogumil, H., Banan, R., Dohmen, H., Acker, T., Brandner, S., Schmid, S., Capper, D., Grassl, N., Boldt, H. B., ... Suwala, A. K. (2025). Loss of global DNA hypermethylation is prognostic in IDH-mutant and 1p/19q-codeleted oligodendrogliomas. Acta Neuropathologica, 150(1), Article 56. https://doi.org/10.1007/s00401-025-02963-7

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title = "Loss of global DNA hypermethylation is prognostic in IDH-mutant and 1p/19q-codeleted oligodendrogliomas",

author = "Hinz, \{Felix E.\} and Dennis Friedel and Ippen, \{Franziska M.\} and Martin Sill and Andrey Korshunov and Leonille Schweizer and Daniel Schrimpf and Kirsten G{\"o}bel and Friedrich, \{Lukas S.\} and Aras, \{Fuat K.\} and Henri Bogumil and Rouzbeh Banan and Hildegard Dohmen and Till Acker and Sebastian Brandner and Simone Schmid and David Capper and Niklas Grassl and Boldt, \{Henning B.\} and Pieter Wesseling and Maas, \{Sybren L.N.\} and Martinez, \{Juan P.Garces\} and Christine Stadelmann and Guido Reifenberger and Thomas Stehle and Alonso Barrantes-Freer and Juratli, \{Tareq A.\} and Stefan Pusch and Daniel Haag and Reuss, \{David E.\} and Christel Herold-Mende and Sandro Krieg and Wolfgang Wick and Nima Etminan and Michael Platten and Pfister, \{Stefan M.\} and Jones, \{David T.W.\} and Felix Sahm and \{von Deimling\}, Andreas and Suwala, \{Abigail K.\}",

year = "2025",

month = nov,

day = "26",

doi = "10.1007/s00401-025-02963-7",

language = "English",

volume = "150",

journal = "Acta Neuropathologica",

issn = "0001-6322",

publisher = "Springer Science+Business Media",

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Hinz, FE, Friedel, D, Ippen, FM, Sill, M, Korshunov, A, Schweizer, L, Schrimpf, D, Göbel, K, Friedrich, LS, Aras, FK, Bogumil, H, Banan, R, Dohmen, H, Acker, T, Brandner, S, Schmid, S, Capper, D, Grassl, N, Boldt, HB, Wesseling, P, Maas, SLN, Martinez, JPG, Stadelmann, C, Reifenberger, G, Stehle, T, Barrantes-Freer, A, Juratli, TA, Pusch, S, Haag, D, Reuss, DE, Herold-Mende, C, Krieg, S, Wick, W, Etminan, N, Platten, M, Pfister, SM, Jones, DTW, Sahm, F, von Deimling, A & Suwala, AK 2025, 'Loss of global DNA hypermethylation is prognostic in IDH-mutant and 1p/19q-codeleted oligodendrogliomas', Acta Neuropathologica, vol. 150, no. 1, 56. https://doi.org/10.1007/s00401-025-02963-7

TY - JOUR

T1 - Loss of global DNA hypermethylation is prognostic in IDH-mutant and 1p/19q-codeleted oligodendrogliomas

AU - Hinz, Felix E.

AU - Friedel, Dennis

AU - Ippen, Franziska M.

AU - Sill, Martin

AU - Korshunov, Andrey

AU - Schweizer, Leonille

AU - Schrimpf, Daniel

AU - Göbel, Kirsten

AU - Friedrich, Lukas S.

AU - Aras, Fuat K.

AU - Bogumil, Henri

AU - Banan, Rouzbeh

AU - Dohmen, Hildegard

AU - Acker, Till

AU - Brandner, Sebastian

AU - Schmid, Simone

AU - Capper, David

AU - Grassl, Niklas

AU - Boldt, Henning B.

AU - Wesseling, Pieter

AU - Maas, Sybren L.N.

AU - Martinez, Juan P.Garces

AU - Stadelmann, Christine

AU - Reifenberger, Guido

AU - Stehle, Thomas

AU - Barrantes-Freer, Alonso

AU - Juratli, Tareq A.

AU - Pusch, Stefan

AU - Haag, Daniel

AU - Reuss, David E.

AU - Herold-Mende, Christel

AU - Krieg, Sandro

AU - Wick, Wolfgang

AU - Etminan, Nima

AU - Platten, Michael

AU - Pfister, Stefan M.

AU - Jones, David T.W.

AU - Sahm, Felix

AU - von Deimling, Andreas

AU - Suwala, Abigail K.

PY - 2025/11/26

Y1 - 2025/11/26

UR - https://www.scopus.com/pages/publications/105023207052

U2 - 10.1007/s00401-025-02963-7

DO - 10.1007/s00401-025-02963-7

M3 - Article

C2 - 41299137

AN - SCOPUS:105023207052

SN - 0001-6322

VL - 150

JO - Acta Neuropathologica

JF - Acta Neuropathologica

IS - 1

M1 - 56

ER -

Loss of global DNA hypermethylation is prognostic in IDH-mutant and 1p/19q-codeleted oligodendrogliomas

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