Low bone mineral density in ambulatory persons with cerebral palsy? A systematic review

CTR Mus-Peters, BMA Huisstede, Suzie Noten, M Hitters, Wilma van der Slot, RJG van den Berg-Emons

Research output: Contribution to journalArticleAcademicpeer-review

16 Citations (Scopus)
41 Downloads (Pure)

Abstract

Purpose: Non-ambulatory persons with cerebral palsy are prone to low bone mineral density. In ambulatory persons with cerebral palsy, bone mineral density deficits are expected to be small or absent, but a consensus conclusion is lacking. In this systematic review bone mineral density in ambulatory persons with cerebral palsy (Gross Motor Function Classification Scales I–III) was studied.

Materials and methods: Medline, Embase, and Web of Science were searched. According to international guidelines, low bone mineral density was defined as Z-score ≤ −2.0. In addition, we focused on Z-score ≤ −1.0 because this may indicate a tendency towards low bone mineral density.

Results: We included 16 studies, comprising 465 patients aged 1–65 years. Moderate and conflicting evidence for low bone mineral density (Z-score ≤ −2.0) was found for several body parts (total proximal femur, total body, distal femur, lumbar spine) in children with Gross Motor Function Classification Scales II and III. We found no evidence for low bone mineral density in children with Gross Motor Function Classification Scale I or adults, although there was a tendency towards low bone mineral density (Z-score ≤ −1.0) for several body parts.

Conclusions: Although more high-quality research is needed, results indicate that deficits in bone mineral density are not restricted to non-ambulatory people with cerebral palsy.
Original languageEnglish
Pages (from-to)2392-2402
Number of pages11
JournalDisability and Rehabilitation
Volume41
Issue number20
DOIs
Publication statusPublished - 2019

Research programs

  • EMC OR-01

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