Low circulating IGF-I bioactivity is associated with human longevity: Findings in centenarians' offspring

G (Giovanni) Vitale; Michel Brugts; G Ogliari; D Castaldi; LM Fatti; Aimee Varewijck; S.W.J. Lamberts; D Monti; L Bucci; E Cevenini; F Cavagnini; C Franceschi; Leo Hofland; D Mari; J.A.M.J.L. Janssen

Low circulating IGF-I bioactivity is associated with human longevity: Findings in centenarians' offspring

G (Giovanni) Vitale, Michel Brugts, G Ogliari, D Castaldi, LM Fatti, Aimee Varewijck, S.W.J. Lamberts, D Monti, L Bucci, E Cevenini, F Cavagnini, C Franceschi, Leo Hofland, D Mari, J.A.M.J.L. Janssen

Internal Medicine

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Abstract

Centenarians' offspring represent a suitable model to study age-dependent variables (e. g. IGF-I) potentially involved in the modulation of the lifespan. The aim of the present study was to investigate the role of the IGF-I in human longevity. We evaluated circulating IGF-I bioactivity measured by an innovative IGF-I Kinase Receptor Activation (KIRA) Assay, total IGF-I, IGFBP-3, total IGF-II, insulin, glucose, HOMA2-B% and HOMA2-S% in 192 centenarians' offspring and 80 offspring-controls of which both parents died relatively young. Both groups were well-matched for age, gender and BMI with the centenarians' offspring. IGF-I bioactivity (p<0.01), total IGF-I (p<0.01) and the IGF-I/IGFBP-3 molar ratio (p<0.001) were significantly lower in centenarians' offspring compared to offspring matched-controls. Serum insulin, glucose, HOMA2-B% and HOMA2-S% values were similar between both groups. In centenarians' offspring IGF-I bioactivity was inversely associated to insulin sensitivity. In conclusion: 1) centenarians' offspring had relatively lower circulating IGF-I bioactivity compared to offspring matched-controls; 2) IGF-I bioactivity in centenarians' offspring was inversely related to insulin sensitivity. These data support a role of the IGF-I/insulin system in the modulation of human aging process.

Original language	Undefined/Unknown
Pages (from-to)	580-589
Number of pages	10
Journal	Aging-Us
Volume	4
Issue number	9
Publication status	Published - 2012

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EMC MM-01-39-01

Cite this

@article{a26a1b97ab0b48d58982191f4c3f7b3f,

title = "Low circulating IGF-I bioactivity is associated with human longevity: Findings in centenarians' offspring",

abstract = "Centenarians' offspring represent a suitable model to study age-dependent variables (e. g. IGF-I) potentially involved in the modulation of the lifespan. The aim of the present study was to investigate the role of the IGF-I in human longevity. We evaluated circulating IGF-I bioactivity measured by an innovative IGF-I Kinase Receptor Activation (KIRA) Assay, total IGF-I, IGFBP-3, total IGF-II, insulin, glucose, HOMA2-B% and HOMA2-S% in 192 centenarians' offspring and 80 offspring-controls of which both parents died relatively young. Both groups were well-matched for age, gender and BMI with the centenarians' offspring. IGF-I bioactivity (p<0.01), total IGF-I (p<0.01) and the IGF-I/IGFBP-3 molar ratio (p<0.001) were significantly lower in centenarians' offspring compared to offspring matched-controls. Serum insulin, glucose, HOMA2-B% and HOMA2-S% values were similar between both groups. In centenarians' offspring IGF-I bioactivity was inversely associated to insulin sensitivity. In conclusion: 1) centenarians' offspring had relatively lower circulating IGF-I bioactivity compared to offspring matched-controls; 2) IGF-I bioactivity in centenarians' offspring was inversely related to insulin sensitivity. These data support a role of the IGF-I/insulin system in the modulation of human aging process.",

author = "Vitale, {G (Giovanni)} and Michel Brugts and G Ogliari and D Castaldi and LM Fatti and Aimee Varewijck and S.W.J. Lamberts and D Monti and L Bucci and E Cevenini and F Cavagnini and C Franceschi and Leo Hofland and D Mari and J.A.M.J.L. Janssen",

year = "2012",

language = "Undefined/Unknown",

volume = "4",

pages = "580--589",

journal = "Aging-Us",

issn = "1945-4589",

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TY - JOUR

T1 - Low circulating IGF-I bioactivity is associated with human longevity: Findings in centenarians' offspring

AU - Vitale, G (Giovanni)

AU - Brugts, Michel

AU - Ogliari, G

AU - Castaldi, D

AU - Fatti, LM

AU - Varewijck, Aimee

AU - Lamberts, S.W.J.

AU - Monti, D

AU - Bucci, L

AU - Cevenini, E

AU - Cavagnini, F

AU - Franceschi, C

AU - Hofland, Leo

AU - Mari, D

AU - Janssen, J.A.M.J.L.

PY - 2012

Y1 - 2012

N2 - Centenarians' offspring represent a suitable model to study age-dependent variables (e. g. IGF-I) potentially involved in the modulation of the lifespan. The aim of the present study was to investigate the role of the IGF-I in human longevity. We evaluated circulating IGF-I bioactivity measured by an innovative IGF-I Kinase Receptor Activation (KIRA) Assay, total IGF-I, IGFBP-3, total IGF-II, insulin, glucose, HOMA2-B% and HOMA2-S% in 192 centenarians' offspring and 80 offspring-controls of which both parents died relatively young. Both groups were well-matched for age, gender and BMI with the centenarians' offspring. IGF-I bioactivity (p<0.01), total IGF-I (p<0.01) and the IGF-I/IGFBP-3 molar ratio (p<0.001) were significantly lower in centenarians' offspring compared to offspring matched-controls. Serum insulin, glucose, HOMA2-B% and HOMA2-S% values were similar between both groups. In centenarians' offspring IGF-I bioactivity was inversely associated to insulin sensitivity. In conclusion: 1) centenarians' offspring had relatively lower circulating IGF-I bioactivity compared to offspring matched-controls; 2) IGF-I bioactivity in centenarians' offspring was inversely related to insulin sensitivity. These data support a role of the IGF-I/insulin system in the modulation of human aging process.

AB - Centenarians' offspring represent a suitable model to study age-dependent variables (e. g. IGF-I) potentially involved in the modulation of the lifespan. The aim of the present study was to investigate the role of the IGF-I in human longevity. We evaluated circulating IGF-I bioactivity measured by an innovative IGF-I Kinase Receptor Activation (KIRA) Assay, total IGF-I, IGFBP-3, total IGF-II, insulin, glucose, HOMA2-B% and HOMA2-S% in 192 centenarians' offspring and 80 offspring-controls of which both parents died relatively young. Both groups were well-matched for age, gender and BMI with the centenarians' offspring. IGF-I bioactivity (p<0.01), total IGF-I (p<0.01) and the IGF-I/IGFBP-3 molar ratio (p<0.001) were significantly lower in centenarians' offspring compared to offspring matched-controls. Serum insulin, glucose, HOMA2-B% and HOMA2-S% values were similar between both groups. In centenarians' offspring IGF-I bioactivity was inversely associated to insulin sensitivity. In conclusion: 1) centenarians' offspring had relatively lower circulating IGF-I bioactivity compared to offspring matched-controls; 2) IGF-I bioactivity in centenarians' offspring was inversely related to insulin sensitivity. These data support a role of the IGF-I/insulin system in the modulation of human aging process.

M3 - Article

SN - 1945-4589

VL - 4

SP - 580

EP - 589

JO - Aging-Us

JF - Aging-Us

IS - 9

ER -