Low-Frequency Synonymous Coding Variation in CYP2R1 Has Large Effects on Vitamin D Levels and Risk of Multiple Sclerosis

D Manousaki; T Dudding; S Haworth; YH Hsu; CT Liu; Maria Medina Gomez; Trudy Voortman; Nathalie van der Velde; H Melhus; C Robinson-Cohen; DL Cousminer; M Nethander; L Vandenput; R Noordam; V Forgetta; CMT Greenwood; ML Biggs; BM Psaty; JI Rotter; BS Zemel; JA Mitchell; B Taylor; M Lorentzon; M Karlsson; Vincent Jaddoe; Henning Tiemeier; N Campos-Obando; OH Franco Duran; André Uitterlinden; Linda Broer; NM Schoor; Annelies Ham; Arfan Ikram; D Karasik; R de Mutsert; FR Rosendaal; M Heijer; TJ Wang; L Lind; ES Orwoll; DO Mook-Kanamori; K Michaelsson; B Kestenbaum; C Ohlsson; D Mellstrom; LCPGM (Lisette) de Groot; SFA Grant; DP Kiel; M.C. Zillikens; Fernando Rivadeneira; S Sawcer; NJ Timpson; JB Richards

doi:10.1016/j.ajhg.2017.06.014

Low-Frequency Synonymous Coding Variation in CYP2R1 Has Large Effects on Vitamin D Levels and Risk of Multiple Sclerosis

D Manousaki, T Dudding, S Haworth, YH Hsu, CT Liu, Maria Medina Gomez, Trudy Voortman, Nathalie van der Velde, H Melhus, C Robinson-Cohen, DL Cousminer, M Nethander, L Vandenput, R Noordam, V Forgetta, CMT Greenwood, ML Biggs, BM Psaty, JI Rotter, BS ZemelJA Mitchell, B Taylor, M Lorentzon, M Karlsson, Vincent Jaddoe, Henning Tiemeier, N Campos-Obando, OH Franco Duran, André Uitterlinden, Linda Broer, NM Schoor, Annelies Ham, Arfan Ikram, D Karasik, R de Mutsert, FR Rosendaal, M Heijer, TJ Wang, L Lind, ES Orwoll, DO Mook-Kanamori, K Michaelsson, B Kestenbaum, C Ohlsson, D Mellstrom, LCPGM (Lisette) de Groot, SFA Grant, DP Kiel, M.C. Zillikens, Fernando Rivadeneira, S Sawcer, NJ Timpson, JB Richards

Research output: Contribution to journal › Article › Academic › peer-review

98 Citations (Scopus)

Original language	English
Pages (from-to)	227-238
Number of pages	12
Journal	American Journal of Human Genetics
Volume	101
Issue number	2
DOIs	https://doi.org/10.1016/j.ajhg.2017.06.014
Publication status	Published - 2017

Research programs

EMC MM-04-54-08-A
EMC NIHES-01-64-01
EMC NIHES-03-30-02
EMC OR-01-39-08

Access to Document

10.1016/j.ajhg.2017.06.014

http://hdl.handle.net/1765/101026

Cite this

Manousaki, D., Dudding, T., Haworth, S., Hsu, YH., Liu, CT., Medina Gomez, M., Voortman, T., van der Velde, N., Melhus, H., Robinson-Cohen, C., Cousminer, DL., Nethander, M., Vandenput, L., Noordam, R., Forgetta, V., Greenwood, CMT., Biggs, ML., Psaty, BM., Rotter, JI., ... Richards, JB. (2017). Low-Frequency Synonymous Coding Variation in CYP2R1 Has Large Effects on Vitamin D Levels and Risk of Multiple Sclerosis. American Journal of Human Genetics, 101(2), 227-238. https://doi.org/10.1016/j.ajhg.2017.06.014

@article{d39f64a97e2445bd8d2b50aaaaa0dd80,

title = "Low-Frequency Synonymous Coding Variation in CYP2R1 Has Large Effects on Vitamin D Levels and Risk of Multiple Sclerosis",

author = "D Manousaki and T Dudding and S Haworth and YH Hsu and CT Liu and {Medina Gomez}, Maria and Trudy Voortman and {van der Velde}, Nathalie and H Melhus and C Robinson-Cohen and DL Cousminer and M Nethander and L Vandenput and R Noordam and V Forgetta and CMT Greenwood and ML Biggs and BM Psaty and JI Rotter and BS Zemel and JA Mitchell and B Taylor and M Lorentzon and M Karlsson and Vincent Jaddoe and Henning Tiemeier and N Campos-Obando and {Franco Duran}, OH and Andr{\'e} Uitterlinden and Linda Broer and NM Schoor and Annelies Ham and Arfan Ikram and D Karasik and {de Mutsert}, R and FR Rosendaal and M Heijer and TJ Wang and L Lind and ES Orwoll and DO Mook-Kanamori and K Michaelsson and B Kestenbaum and C Ohlsson and D Mellstrom and {de Groot}, {LCPGM (Lisette)} and SFA Grant and DP Kiel and M.C. Zillikens and Fernando Rivadeneira and S Sawcer and NJ Timpson and JB Richards",

year = "2017",

doi = "10.1016/j.ajhg.2017.06.014",

language = "English",

volume = "101",

pages = "227--238",

journal = "American Journal of Human Genetics",

issn = "0002-9297",

publisher = "Cell Press",

number = "2",

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Manousaki, D, Dudding, T, Haworth, S, Hsu, YH, Liu, CT, Medina Gomez, M , Voortman, T , van der Velde, N, Melhus, H, Robinson-Cohen, C, Cousminer, DL, Nethander, M, Vandenput, L, Noordam, R, Forgetta, V, Greenwood, CMT, Biggs, ML, Psaty, BM, Rotter, JI, Zemel, BS, Mitchell, JA, Taylor, B, Lorentzon, M, Karlsson, M, Jaddoe, V, Tiemeier, H, Campos-Obando, N, Franco Duran, OH, Uitterlinden, A , Broer, L, Schoor, NM, Ham, A, Ikram, A, Karasik, D, de Mutsert, R, Rosendaal, FR, Heijer, M, Wang, TJ, Lind, L, Orwoll, ES, Mook-Kanamori, DO, Michaelsson, K, Kestenbaum, B, Ohlsson, C, Mellstrom, D, de Groot, LCPGM, Grant, SFA, Kiel, DP, Zillikens, MC, Rivadeneira, F, Sawcer, S, Timpson, NJ & Richards, JB 2017, 'Low-Frequency Synonymous Coding Variation in CYP2R1 Has Large Effects on Vitamin D Levels and Risk of Multiple Sclerosis', American Journal of Human Genetics, vol. 101, no. 2, pp. 227-238. https://doi.org/10.1016/j.ajhg.2017.06.014

TY - JOUR

T1 - Low-Frequency Synonymous Coding Variation in CYP2R1 Has Large Effects on Vitamin D Levels and Risk of Multiple Sclerosis

AU - Manousaki, D

AU - Dudding, T

AU - Haworth, S

AU - Hsu, YH

AU - Liu, CT

AU - Medina Gomez, Maria

AU - Voortman, Trudy

AU - van der Velde, Nathalie

AU - Melhus, H

AU - Robinson-Cohen, C

AU - Cousminer, DL

AU - Nethander, M

AU - Vandenput, L

AU - Noordam, R

AU - Forgetta, V

AU - Greenwood, CMT

AU - Biggs, ML

AU - Psaty, BM

AU - Rotter, JI

AU - Zemel, BS

AU - Mitchell, JA

AU - Taylor, B

AU - Lorentzon, M

AU - Karlsson, M

AU - Jaddoe, Vincent

AU - Tiemeier, Henning

AU - Campos-Obando, N

AU - Franco Duran, OH

AU - Uitterlinden, André

AU - Broer, Linda

AU - Schoor, NM

AU - Ham, Annelies

AU - Ikram, Arfan

AU - Karasik, D

AU - de Mutsert, R

AU - Rosendaal, FR

AU - Heijer, M

AU - Wang, TJ

AU - Lind, L

AU - Orwoll, ES

AU - Mook-Kanamori, DO

AU - Michaelsson, K

AU - Kestenbaum, B

AU - Ohlsson, C

AU - Mellstrom, D

AU - de Groot, LCPGM (Lisette)

AU - Grant, SFA

AU - Kiel, DP

AU - Zillikens, M.C.

AU - Rivadeneira, Fernando

AU - Sawcer, S

AU - Timpson, NJ

AU - Richards, JB

PY - 2017

Y1 - 2017

U2 - 10.1016/j.ajhg.2017.06.014

DO - 10.1016/j.ajhg.2017.06.014

M3 - Article

SN - 0002-9297

VL - 101

SP - 227

EP - 238

JO - American Journal of Human Genetics

JF - American Journal of Human Genetics

IS - 2

ER -