Low-Frequency Variants in HMGA1 Are Not Associated With Type 2 Diabetes Risk

M Marquez; M Huyvaert; JRB Perry; RD Pearson; M Falchi; AP Morris; S Vivequin; S Lobbens; L Yengo; S Gaget; F Pattou; O Poulain-Godefroy; G Charpentier; LMS Carlsson; P Jacobson; L Sjostrom; O Lantieri; B Heude; A Walley; B Balkau; M (Michel) Marre; P Froguel; S Cauchi

doi:10.2337/db11-0728

Low-Frequency Variants in HMGA1 Are Not Associated With Type 2 Diabetes Risk

M Marquez, M Huyvaert, JRB Perry, RD Pearson, M Falchi, AP Morris, S Vivequin, S Lobbens, L Yengo, S Gaget, F Pattou, O Poulain-Godefroy, G Charpentier, LMS Carlsson, P Jacobson, L Sjostrom, O Lantieri, B Heude, A Walley, B BalkauM (Michel) Marre, P Froguel, S Cauchi

Erasmus MC other

Research output: Contribution to journal › Article › Academic › peer-review

14 Citations (Scopus)

Abstract

It has recently been suggested that the low-frequency c.136-14_136-13insC variant in high-mobility group Al (HMGA1) may strongly contribute to insulin resistance and type 2 diabetes risk. In our study, we attempted to confirm that HMGA1 is a novel type 2 diabetes locus in French Caucasians. The gene was sequenced in 368 type 2 diabetic case subjects with a family history of type 2 diabetes and 372 normoglycemic control subjects without a family history of type 2 diabetes. None of the 41 genetic variations identified were associated with type 2 diabetes. The lack of association between the c.136-14_136-13insC variant and type 2 diabetes was confirmed in an independent French group of 4,538 case subjects and 4,015 control subjects and in a large meta-analysis of 16,605 case subjects and 46,179 control subjects. Finally, this variant had no effects on metabolic traits and was not involved in variations of HMGA1 and insulin receptor (INSR) expressions. The c.136-14_136-13insC variant was not associated with type 2 diabetes in individuals of European descent. Our study emphasizes the need to analyze a large number of subjects to reliably assess the association of low-frequency variants with the disease. Diabetes 61:524-530, 2012

Original language	Undefined/Unknown
Pages (from-to)	524-530
Number of pages	7
Journal	Diabetes
Volume	61
Issue number	2
DOIs	https://doi.org/10.2337/db11-0728
Publication status	Published - 2012

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10.2337/db11-0728

Cite this

Marquez, M., Huyvaert, M., Perry, JRB., Pearson, RD., Falchi, M., Morris, AP., Vivequin, S., Lobbens, S., Yengo, L., Gaget, S., Pattou, F., Poulain-Godefroy, O., Charpentier, G., Carlsson, LMS., Jacobson, P., Sjostrom, L., Lantieri, O., Heude, B., Walley, A., ... Cauchi, S. (2012). Low-Frequency Variants in HMGA1 Are Not Associated With Type 2 Diabetes Risk. Diabetes, 61(2), 524-530. https://doi.org/10.2337/db11-0728

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title = "Low-Frequency Variants in HMGA1 Are Not Associated With Type 2 Diabetes Risk",

abstract = "It has recently been suggested that the low-frequency c.136-14_136-13insC variant in high-mobility group Al (HMGA1) may strongly contribute to insulin resistance and type 2 diabetes risk. In our study, we attempted to confirm that HMGA1 is a novel type 2 diabetes locus in French Caucasians. The gene was sequenced in 368 type 2 diabetic case subjects with a family history of type 2 diabetes and 372 normoglycemic control subjects without a family history of type 2 diabetes. None of the 41 genetic variations identified were associated with type 2 diabetes. The lack of association between the c.136-14_136-13insC variant and type 2 diabetes was confirmed in an independent French group of 4,538 case subjects and 4,015 control subjects and in a large meta-analysis of 16,605 case subjects and 46,179 control subjects. Finally, this variant had no effects on metabolic traits and was not involved in variations of HMGA1 and insulin receptor (INSR) expressions. The c.136-14_136-13insC variant was not associated with type 2 diabetes in individuals of European descent. Our study emphasizes the need to analyze a large number of subjects to reliably assess the association of low-frequency variants with the disease. Diabetes 61:524-530, 2012",

author = "M Marquez and M Huyvaert and JRB Perry and RD Pearson and M Falchi and AP Morris and S Vivequin and S Lobbens and L Yengo and S Gaget and F Pattou and O Poulain-Godefroy and G Charpentier and LMS Carlsson and P Jacobson and L Sjostrom and O Lantieri and B Heude and A Walley and B Balkau and Marre, {M (Michel)} and P Froguel and S Cauchi",

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doi = "10.2337/db11-0728",

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Marquez, M, Huyvaert, M, Perry, JRB, Pearson, RD, Falchi, M, Morris, AP, Vivequin, S, Lobbens, S, Yengo, L, Gaget, S, Pattou, F, Poulain-Godefroy, O, Charpentier, G, Carlsson, LMS, Jacobson, P, Sjostrom, L, Lantieri, O, Heude, B, Walley, A, Balkau, B, Marre, M, Froguel, P & Cauchi, S 2012, 'Low-Frequency Variants in HMGA1 Are Not Associated With Type 2 Diabetes Risk', Diabetes, vol. 61, no. 2, pp. 524-530. https://doi.org/10.2337/db11-0728

TY - JOUR

T1 - Low-Frequency Variants in HMGA1 Are Not Associated With Type 2 Diabetes Risk

AU - Marquez, M

AU - Huyvaert, M

AU - Perry, JRB

AU - Pearson, RD

AU - Falchi, M

AU - Morris, AP

AU - Vivequin, S

AU - Lobbens, S

AU - Yengo, L

AU - Gaget, S

AU - Pattou, F

AU - Poulain-Godefroy, O

AU - Charpentier, G

AU - Carlsson, LMS

AU - Jacobson, P

AU - Sjostrom, L

AU - Lantieri, O

AU - Heude, B

AU - Walley, A

AU - Balkau, B

AU - Marre, M (Michel)

AU - Froguel, P

AU - Cauchi, S

PY - 2012

Y1 - 2012

N2 - It has recently been suggested that the low-frequency c.136-14_136-13insC variant in high-mobility group Al (HMGA1) may strongly contribute to insulin resistance and type 2 diabetes risk. In our study, we attempted to confirm that HMGA1 is a novel type 2 diabetes locus in French Caucasians. The gene was sequenced in 368 type 2 diabetic case subjects with a family history of type 2 diabetes and 372 normoglycemic control subjects without a family history of type 2 diabetes. None of the 41 genetic variations identified were associated with type 2 diabetes. The lack of association between the c.136-14_136-13insC variant and type 2 diabetes was confirmed in an independent French group of 4,538 case subjects and 4,015 control subjects and in a large meta-analysis of 16,605 case subjects and 46,179 control subjects. Finally, this variant had no effects on metabolic traits and was not involved in variations of HMGA1 and insulin receptor (INSR) expressions. The c.136-14_136-13insC variant was not associated with type 2 diabetes in individuals of European descent. Our study emphasizes the need to analyze a large number of subjects to reliably assess the association of low-frequency variants with the disease. Diabetes 61:524-530, 2012

AB - It has recently been suggested that the low-frequency c.136-14_136-13insC variant in high-mobility group Al (HMGA1) may strongly contribute to insulin resistance and type 2 diabetes risk. In our study, we attempted to confirm that HMGA1 is a novel type 2 diabetes locus in French Caucasians. The gene was sequenced in 368 type 2 diabetic case subjects with a family history of type 2 diabetes and 372 normoglycemic control subjects without a family history of type 2 diabetes. None of the 41 genetic variations identified were associated with type 2 diabetes. The lack of association between the c.136-14_136-13insC variant and type 2 diabetes was confirmed in an independent French group of 4,538 case subjects and 4,015 control subjects and in a large meta-analysis of 16,605 case subjects and 46,179 control subjects. Finally, this variant had no effects on metabolic traits and was not involved in variations of HMGA1 and insulin receptor (INSR) expressions. The c.136-14_136-13insC variant was not associated with type 2 diabetes in individuals of European descent. Our study emphasizes the need to analyze a large number of subjects to reliably assess the association of low-frequency variants with the disease. Diabetes 61:524-530, 2012

U2 - 10.2337/db11-0728

DO - 10.2337/db11-0728

M3 - Article

C2 - 22210315

SN - 0012-1797

VL - 61

SP - 524

EP - 530

JO - Diabetes

JF - Diabetes

IS - 2

ER -