Low-frequency variation in TP53 has large effects on head circumference and intracranial volume

S Haworth; CY Shapland; C Hayward; BP Prins; Janine Felix; Maria Medina Gomez; Fernando Rivadeneira; C Wang; TS Ahluwalia; M Vrijheid; Monica Guxens Junyent; J Sunyer; I Tachmazidou; K Walter; V Iotchkova; A Jackson; L Cleal; J Huffmann; JL Min; L Sass; P Timmers; S Al Turki; CA Anderson; R Anney; D Antony; MS Artigas; M Ayub; S Bala; JC Barrett; I Barroso; P Beales; J Bentham; S Bhattacharya; E Birney; D Blackwood; M Bobrow; E Bochukova; PF Bolton; R Bounds; C Boustred; G Breen; M Calissano; K Carss; R Charlton; K Chatterjee; L Chen; A Ciampi; S Cirak; P Clapham; G Clement; G Coates; M Cocca; DA Collier; C Cosgrove; T Cox; N Craddock; L Crooks; S Curran; D Curtis; A Daly; P Danecek; INM Day; A Day-Williams; A Dominiczak; T Down; YP Du; I Dunham; R Durbin; S Edkins; R Ekong; P Ellis; DM Evans; IS Farooqi; DR Fitzpatrick; P Flicek; J Floyd; AR Foley; CS Franklin; M Futema; L Gallagher; TR Gaunt; M Geihs; D Geschwind; CMT Greenwood; H Griffin; D Grozeva; XS Guo; XQ Guo; H Gurling; D Hart; AE Hendricks; P Holmans; B Howie; J Huang; LR Huang; T Hubbard; SE Humphries; ME Hurles; P Hysi; DK Jackson; Y Jamshidi; C Joyce; KJ Karczewski; J Kaye; T Keane; JP Kemp; K Kennedy; A Kent; J Keogh; F Khawaja; M van Kogelenberg; A Kolb-Kokocinski; G Lachance; C Langford; D Lawson; I Lee; M Lek; R Li; YR Li; JQ Liang; H Lin; R Liu; J Lonnqvist; LR Lopes; M Lopes; DG MacArthur; M Mangino; J Marchini; G Marenne; J Maslen; I Mathieson; S McCarthy; P McGuffin; AM McIntosh; AG McKechanie; A McQuillin; Y Memari; S Metrustry; N Migone; HM Mitchison; A Moayyeri; A Morris; J Morris; D Muddyman; F Muntoni; K Northstone; MC O'Donovan; S O'Rahilly; A Onoufriadis; K Oualkacha; MJ Owen; A Palotie; K Panoutsopoulou; V Parker; JR Parr; L Paternoster; T Paunio; F Payne; SJ Payne; JRB Perry; O Pietilainen; V Plagnol; RC Pollitt; DJ Porteous; S Povey; MA Quail; L Quaye; FL Raymond; K Rehnstrom; JB Richards; CK Ridout; S Ring; GRS Ritchie; N Roberts; RL Robinson; DB Savage; P Scambler; S Schiffels; M Schmidts; N Schoenmakers; RH Scott; RK Semple; E Serra; SI Sharp; A Shaw; HA Shihab; SY Shin; D Skuse; KS Small; C Smee; BH Smith; N Soranzo; L Southam; O Spasic-Boskovic; TD Spector; D St Clair; J Stalker; E Stevens; JP Sun; G Surdulescu; J Suvisaari; P Syrris; R Taylor; J Tian; MD Tobin; AM Valdes; AM Vandersteen; P Vijayarangakannan; PM Visscher; LV Wain; JTR Walters; G B Wang; Johnny Wang; Y Wang; K Ward; E Wheeler; T Whyte; HJ Williams; KA Williamson; C Wilson; SG Wilson; K Wong; CJ Xu; Jiaqi Yang; F Zhang; PB Zhang; HF Zheng; GD Smith; SE Fisher; JF Wilson; TJ Cole; D Fernandez-Orth; K Bonnelykke; H Bisgaard; CE Pennell; Vincent Jaddoe; G Dedoussis; N Timpson; E Zeggini; V Vitart; B St Pourcain

doi:10.1038/s41467-018-07863-x

Low-frequency variation in TP53 has large effects on head circumference and intracranial volume

S Haworth, CY Shapland, C Hayward, BP Prins, Janine Felix, Maria Medina Gomez, Fernando Rivadeneira, C Wang, TS Ahluwalia, M Vrijheid, Monica Guxens Junyent, J Sunyer, I Tachmazidou, K Walter, V Iotchkova, A Jackson, L Cleal, J Huffmann, JL Min, L SassP Timmers, S Al Turki, CA Anderson, R Anney, D Antony, MS Artigas, M Ayub, S Bala, JC Barrett, I Barroso, P Beales, J Bentham, S Bhattacharya, E Birney, D Blackwood, M Bobrow, E Bochukova, PF Bolton, R Bounds, C Boustred, G Breen, M Calissano, K Carss, R Charlton, K Chatterjee, L Chen, A Ciampi, S Cirak, P Clapham, G Clement, G Coates, M Cocca, DA Collier, C Cosgrove, T Cox, N Craddock, L Crooks, S Curran, D Curtis, A Daly, P Danecek, INM Day, A Day-Williams, A Dominiczak, T Down, YP Du, I Dunham, R Durbin, S Edkins, R Ekong, P Ellis, DM Evans, IS Farooqi, DR Fitzpatrick, P Flicek, J Floyd, AR Foley, CS Franklin, M Futema, L Gallagher, TR Gaunt, M Geihs, D Geschwind, CMT Greenwood, H Griffin, D Grozeva, XS Guo, XQ Guo, H Gurling, D Hart, AE Hendricks, P Holmans, B Howie, J Huang, LR Huang, T Hubbard, SE Humphries, ME Hurles, P Hysi, DK Jackson, Y Jamshidi, C Joyce, KJ Karczewski, J Kaye, T Keane, JP Kemp, K Kennedy, A Kent, J Keogh, F Khawaja, M van Kogelenberg, A Kolb-Kokocinski, G Lachance, C Langford, D Lawson, I Lee, M Lek, R Li, YR Li, JQ Liang, H Lin, R Liu, J Lonnqvist, LR Lopes, M Lopes, DG MacArthur, M Mangino, J Marchini, G Marenne, J Maslen, I Mathieson, S McCarthy, P McGuffin, AM McIntosh, AG McKechanie, A McQuillin, Y Memari, S Metrustry, N Migone, HM Mitchison, A Moayyeri, A Morris, J Morris, D Muddyman, F Muntoni, K Northstone, MC O'Donovan, S O'Rahilly, A Onoufriadis, K Oualkacha, MJ Owen, A Palotie, K Panoutsopoulou, V Parker, JR Parr, L Paternoster, T Paunio, F Payne, SJ Payne, JRB Perry, O Pietilainen, V Plagnol, RC Pollitt, DJ Porteous, S Povey, MA Quail, L Quaye, FL Raymond, K Rehnstrom, JB Richards, CK Ridout, S Ring, GRS Ritchie, N Roberts, RL Robinson, DB Savage, P Scambler, S Schiffels, M Schmidts, N Schoenmakers, RH Scott, RK Semple, E Serra, SI Sharp, A Shaw, HA Shihab, SY Shin, D Skuse, KS Small, C Smee, BH Smith, N Soranzo, L Southam, O Spasic-Boskovic, TD Spector, D St Clair, J Stalker, E Stevens, JP Sun, G Surdulescu, J Suvisaari, P Syrris, R Taylor, J Tian, MD Tobin, AM Valdes, AM Vandersteen, P Vijayarangakannan, PM Visscher, LV Wain, JTR Walters, G B Wang, Johnny Wang, Y Wang, K Ward, E Wheeler, T Whyte, HJ Williams, KA Williamson, C Wilson, SG Wilson, K Wong, CJ Xu, Jiaqi Yang, F Zhang, PB Zhang, HF Zheng, GD Smith, SE Fisher, JF Wilson, TJ Cole, D Fernandez-Orth, K Bonnelykke, H Bisgaard, CE Pennell, Vincent Jaddoe, G Dedoussis, N Timpson, E Zeggini, V Vitart, B St Pourcain

Research output: Contribution to journal › Article › Academic › peer-review

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13 Downloads (Pure)

Original language	Undefined/Unknown
Article number	357
Journal	Nature Communications
Volume	10
DOIs	https://doi.org/10.1038/s41467-018-07863-x
Publication status	Published - 2019

Research programs

EMC MM-01-39-09-A
EMC MM-04-54-08-A

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10.1038/s41467-018-07863-x

Repub_114894_O-A.pdfFinal published version, 1.94 MB

http://hdl.handle.net/1765/114894

Cite this

Haworth, S., Shapland, CY., Hayward, C., Prins, BP., Felix, J., Medina Gomez, M., Rivadeneira, F., Wang, C., Ahluwalia, TS., Vrijheid, M., Guxens Junyent, M., Sunyer, J., Tachmazidou, I., Walter, K., Iotchkova, V., Jackson, A., Cleal, L., Huffmann, J., Min, JL., ... St Pourcain, B. (2019). Low-frequency variation in TP53 has large effects on head circumference and intracranial volume. Nature Communications, 10, Article 357. https://doi.org/10.1038/s41467-018-07863-x

@article{ffa27f512e8a4a2aa00e28d03b0655e1,

title = "Low-frequency variation in TP53 has large effects on head circumference and intracranial volume",

author = "S Haworth and CY Shapland and C Hayward and BP Prins and Janine Felix and {Medina Gomez}, Maria and Fernando Rivadeneira and C Wang and TS Ahluwalia and M Vrijheid and {Guxens Junyent}, Monica and J Sunyer and I Tachmazidou and K Walter and V Iotchkova and A Jackson and L Cleal and J Huffmann and JL Min and L Sass and P Timmers and {Al Turki}, S and CA Anderson and R Anney and D Antony and MS Artigas and M Ayub and S Bala and JC Barrett and I Barroso and P Beales and J Bentham and S Bhattacharya and E Birney and D Blackwood and M Bobrow and E Bochukova and PF Bolton and R Bounds and C Boustred and G Breen and M Calissano and K Carss and R Charlton and K Chatterjee and L Chen and A Ciampi and S Cirak and P Clapham and G Clement and G Coates and M Cocca and DA Collier and C Cosgrove and T Cox and N Craddock and L Crooks and S Curran and D Curtis and A Daly and P Danecek and INM Day and A Day-Williams and A Dominiczak and T Down and YP Du and I Dunham and R Durbin and S Edkins and R Ekong and P Ellis and DM Evans and IS Farooqi and DR Fitzpatrick and P Flicek and J Floyd and AR Foley and CS Franklin and M Futema and L Gallagher and TR Gaunt and M Geihs and D Geschwind and CMT Greenwood and H Griffin and D Grozeva and XS Guo and XQ Guo and H Gurling and D Hart and AE Hendricks and P Holmans and B Howie and J Huang and LR Huang and T Hubbard and SE Humphries and ME Hurles and P Hysi and DK Jackson and Y Jamshidi and C Joyce and KJ Karczewski and J Kaye and T Keane and JP Kemp and K Kennedy and A Kent and J Keogh and F Khawaja and {van Kogelenberg}, M and A Kolb-Kokocinski and G Lachance and C Langford and D Lawson and I Lee and M Lek and R Li and YR Li and JQ Liang and H Lin and R Liu and J Lonnqvist and LR Lopes and M Lopes and DG MacArthur and M Mangino and J Marchini and G Marenne and J Maslen and I Mathieson and S McCarthy and P McGuffin and AM McIntosh and AG McKechanie and A McQuillin and Y Memari and S Metrustry and N Migone and HM Mitchison and A Moayyeri and A Morris and J Morris and D Muddyman and F Muntoni and K Northstone and MC O'Donovan and S O'Rahilly and A Onoufriadis and K Oualkacha and MJ Owen and A Palotie and K Panoutsopoulou and V Parker and JR Parr and L Paternoster and T Paunio and F Payne and SJ Payne and JRB Perry and O Pietilainen and V Plagnol and RC Pollitt and DJ Porteous and S Povey and MA Quail and L Quaye and FL Raymond and K Rehnstrom and JB Richards and CK Ridout and S Ring and GRS Ritchie and N Roberts and RL Robinson and DB Savage and P Scambler and S Schiffels and M Schmidts and N Schoenmakers and RH Scott and RK Semple and E Serra and SI Sharp and A Shaw and HA Shihab and SY Shin and D Skuse and KS Small and C Smee and BH Smith and N Soranzo and L Southam and O Spasic-Boskovic and TD Spector and {St Clair}, D and J Stalker and E Stevens and JP Sun and G Surdulescu and J Suvisaari and P Syrris and R Taylor and J Tian and MD Tobin and AM Valdes and AM Vandersteen and P Vijayarangakannan and PM Visscher and LV Wain and JTR Walters and Wang, {G B} and Johnny Wang and Y Wang and K Ward and E Wheeler and T Whyte and HJ Williams and KA Williamson and C Wilson and SG Wilson and K Wong and CJ Xu and Jiaqi Yang and F Zhang and PB Zhang and HF Zheng and GD Smith and SE Fisher and JF Wilson and TJ Cole and D Fernandez-Orth and K Bonnelykke and H Bisgaard and CE Pennell and Vincent Jaddoe and G Dedoussis and N Timpson and E Zeggini and V Vitart and {St Pourcain}, B",

year = "2019",

doi = "10.1038/s41467-018-07863-x",

language = "Undefined/Unknown",

volume = "10",

journal = "Nature Communications",

issn = "2041-1723",

publisher = "Nature Research",

}

Haworth, S, Shapland, CY, Hayward, C, Prins, BP, Felix, J , Medina Gomez, M , Rivadeneira, F, Wang, C, Ahluwalia, TS, Vrijheid, M, Guxens Junyent, M, Sunyer, J, Tachmazidou, I, Walter, K, Iotchkova, V, Jackson, A, Cleal, L, Huffmann, J, Min, JL, Sass, L, Timmers, P, Al Turki, S, Anderson, CA, Anney, R, Antony, D, Artigas, MS, Ayub, M, Bala, S, Barrett, JC, Barroso, I, Beales, P, Bentham, J, Bhattacharya, S, Birney, E, Blackwood, D, Bobrow, M, Bochukova, E, Bolton, PF, Bounds, R, Boustred, C, Breen, G, Calissano, M, Carss, K, Charlton, R, Chatterjee, K, Chen, L, Ciampi, A, Cirak, S, Clapham, P, Clement, G, Coates, G, Cocca, M, Collier, DA, Cosgrove, C, Cox, T, Craddock, N, Crooks, L, Curran, S, Curtis, D, Daly, A, Danecek, P, Day, INM, Day-Williams, A, Dominiczak, A, Down, T, Du, YP, Dunham, I, Durbin, R, Edkins, S, Ekong, R, Ellis, P, Evans, DM, Farooqi, IS, Fitzpatrick, DR, Flicek, P, Floyd, J, Foley, AR, Franklin, CS, Futema, M, Gallagher, L, Gaunt, TR, Geihs, M, Geschwind, D, Greenwood, CMT, Griffin, H, Grozeva, D, Guo, XS, Guo, XQ, Gurling, H, Hart, D, Hendricks, AE, Holmans, P, Howie, B, Huang, J, Huang, LR, Hubbard, T, Humphries, SE, Hurles, ME, Hysi, P, Jackson, DK, Jamshidi, Y, Joyce, C, Karczewski, KJ, Kaye, J, Keane, T, Kemp, JP, Kennedy, K, Kent, A, Keogh, J, Khawaja, F, van Kogelenberg, M, Kolb-Kokocinski, A, Lachance, G, Langford, C, Lawson, D, Lee, I, Lek, M, Li, R, Li, YR, Liang, JQ, Lin, H, Liu, R, Lonnqvist, J, Lopes, LR, Lopes, M, MacArthur, DG, Mangino, M, Marchini, J, Marenne, G, Maslen, J, Mathieson, I, McCarthy, S, McGuffin, P, McIntosh, AM, McKechanie, AG, McQuillin, A, Memari, Y, Metrustry, S, Migone, N, Mitchison, HM, Moayyeri, A, Morris, A, Morris, J, Muddyman, D, Muntoni, F, Northstone, K, O'Donovan, MC, O'Rahilly, S, Onoufriadis, A, Oualkacha, K, Owen, MJ, Palotie, A, Panoutsopoulou, K, Parker, V, Parr, JR, Paternoster, L, Paunio, T, Payne, F, Payne, SJ, Perry, JRB, Pietilainen, O, Plagnol, V, Pollitt, RC, Porteous, DJ, Povey, S, Quail, MA, Quaye, L, Raymond, FL, Rehnstrom, K, Richards, JB, Ridout, CK, Ring, S, Ritchie, GRS, Roberts, N, Robinson, RL, Savage, DB, Scambler, P, Schiffels, S, Schmidts, M, Schoenmakers, N, Scott, RH, Semple, RK, Serra, E, Sharp, SI, Shaw, A, Shihab, HA, Shin, SY, Skuse, D, Small, KS, Smee, C, Smith, BH, Soranzo, N, Southam, L, Spasic-Boskovic, O, Spector, TD, St Clair, D, Stalker, J, Stevens, E, Sun, JP, Surdulescu, G, Suvisaari, J, Syrris, P, Taylor, R, Tian, J, Tobin, MD, Valdes, AM, Vandersteen, AM, Vijayarangakannan, P, Visscher, PM, Wain, LV, Walters, JTR, Wang, GB, Wang, J, Wang, Y, Ward, K, Wheeler, E, Whyte, T, Williams, HJ, Williamson, KA, Wilson, C, Wilson, SG, Wong, K, Xu, CJ, Yang, J, Zhang, F, Zhang, PB, Zheng, HF, Smith, GD, Fisher, SE, Wilson, JF, Cole, TJ, Fernandez-Orth, D, Bonnelykke, K, Bisgaard, H, Pennell, CE, Jaddoe, V, Dedoussis, G, Timpson, N, Zeggini, E, Vitart, V & St Pourcain, B 2019, 'Low-frequency variation in TP53 has large effects on head circumference and intracranial volume', Nature Communications, vol. 10, 357. https://doi.org/10.1038/s41467-018-07863-x

TY - JOUR

T1 - Low-frequency variation in TP53 has large effects on head circumference and intracranial volume

AU - Haworth, S

AU - Shapland, CY

AU - Hayward, C

AU - Prins, BP

AU - Felix, Janine

AU - Medina Gomez, Maria

AU - Rivadeneira, Fernando

AU - Wang, C

AU - Ahluwalia, TS

AU - Vrijheid, M

AU - Guxens Junyent, Monica

AU - Sunyer, J

AU - Tachmazidou, I

AU - Walter, K

AU - Iotchkova, V

AU - Jackson, A

AU - Cleal, L

AU - Huffmann, J

AU - Min, JL

AU - Sass, L

AU - Timmers, P

AU - Al Turki, S

AU - Anderson, CA

AU - Anney, R

AU - Antony, D

AU - Artigas, MS

AU - Ayub, M

AU - Bala, S

AU - Barrett, JC

AU - Barroso, I

AU - Beales, P

AU - Bentham, J

AU - Bhattacharya, S

AU - Birney, E

AU - Blackwood, D

AU - Bobrow, M

AU - Bochukova, E

AU - Bolton, PF

AU - Bounds, R

AU - Boustred, C

AU - Breen, G

AU - Calissano, M

AU - Carss, K

AU - Charlton, R

AU - Chatterjee, K

AU - Chen, L

AU - Ciampi, A

AU - Cirak, S

AU - Clapham, P

AU - Clement, G

AU - Coates, G

AU - Cocca, M

AU - Collier, DA

AU - Cosgrove, C

AU - Cox, T

AU - Craddock, N

AU - Crooks, L

AU - Curran, S

AU - Curtis, D

AU - Daly, A

AU - Danecek, P

AU - Day, INM

AU - Day-Williams, A

AU - Dominiczak, A

AU - Down, T

AU - Du, YP

AU - Dunham, I

AU - Durbin, R

AU - Edkins, S

AU - Ekong, R

AU - Ellis, P

AU - Evans, DM

AU - Farooqi, IS

AU - Fitzpatrick, DR

AU - Flicek, P

AU - Floyd, J

AU - Foley, AR

AU - Franklin, CS

AU - Futema, M

AU - Gallagher, L

AU - Gaunt, TR

AU - Geihs, M

AU - Geschwind, D

AU - Greenwood, CMT

AU - Griffin, H

AU - Grozeva, D

AU - Guo, XS

AU - Guo, XQ

AU - Gurling, H

AU - Hart, D

AU - Hendricks, AE

AU - Holmans, P

AU - Howie, B

AU - Huang, J

AU - Huang, LR

AU - Hubbard, T

AU - Humphries, SE

AU - Hurles, ME

AU - Hysi, P

AU - Jackson, DK

AU - Jamshidi, Y

AU - Joyce, C

AU - Karczewski, KJ

AU - Kaye, J

AU - Keane, T

AU - Kemp, JP

AU - Kennedy, K

AU - Kent, A

AU - Keogh, J

AU - Khawaja, F

AU - van Kogelenberg, M

AU - Kolb-Kokocinski, A

AU - Lachance, G

AU - Langford, C

AU - Lawson, D

AU - Lee, I

AU - Lek, M

AU - Li, R

AU - Li, YR

AU - Liang, JQ

AU - Lin, H

AU - Liu, R

AU - Lonnqvist, J

AU - Lopes, LR

AU - Lopes, M

AU - MacArthur, DG

AU - Mangino, M

AU - Marchini, J

AU - Marenne, G

AU - Maslen, J

AU - Mathieson, I

AU - McCarthy, S

AU - McGuffin, P

AU - McIntosh, AM

AU - McKechanie, AG

AU - McQuillin, A

AU - Memari, Y

AU - Metrustry, S

AU - Migone, N

AU - Mitchison, HM

AU - Moayyeri, A

AU - Morris, A

AU - Morris, J

AU - Muddyman, D

AU - Muntoni, F

AU - Northstone, K

AU - O'Donovan, MC

AU - O'Rahilly, S

AU - Onoufriadis, A

AU - Oualkacha, K

AU - Owen, MJ

AU - Palotie, A

AU - Panoutsopoulou, K

AU - Parker, V

AU - Parr, JR

AU - Paternoster, L

AU - Paunio, T

AU - Payne, F

AU - Payne, SJ

AU - Perry, JRB

AU - Pietilainen, O

AU - Plagnol, V

AU - Pollitt, RC

AU - Porteous, DJ

AU - Povey, S

AU - Quail, MA

AU - Quaye, L

AU - Raymond, FL

AU - Rehnstrom, K

AU - Richards, JB

AU - Ridout, CK

AU - Ring, S

AU - Ritchie, GRS

AU - Roberts, N

AU - Robinson, RL

AU - Savage, DB

AU - Scambler, P

AU - Schiffels, S

AU - Schmidts, M

AU - Schoenmakers, N

AU - Scott, RH

AU - Semple, RK

AU - Serra, E

AU - Sharp, SI

AU - Shaw, A

AU - Shihab, HA

AU - Shin, SY

AU - Skuse, D

AU - Small, KS

AU - Smee, C

AU - Smith, BH

AU - Soranzo, N

AU - Southam, L

AU - Spasic-Boskovic, O

AU - Spector, TD

AU - St Clair, D

AU - Stalker, J

AU - Stevens, E

AU - Sun, JP

AU - Surdulescu, G

AU - Suvisaari, J

AU - Syrris, P

AU - Taylor, R

AU - Tian, J

AU - Tobin, MD

AU - Valdes, AM

AU - Vandersteen, AM

AU - Vijayarangakannan, P

AU - Visscher, PM

AU - Wain, LV

AU - Walters, JTR

AU - Wang, G B

AU - Wang, Johnny

AU - Wang, Y

AU - Ward, K

AU - Wheeler, E

AU - Whyte, T

AU - Williams, HJ

AU - Williamson, KA

AU - Wilson, C

AU - Wilson, SG

AU - Wong, K

AU - Xu, CJ

AU - Yang, Jiaqi

AU - Zhang, F

AU - Zhang, PB

AU - Zheng, HF

AU - Smith, GD

AU - Fisher, SE

AU - Wilson, JF

AU - Cole, TJ

AU - Fernandez-Orth, D

AU - Bonnelykke, K

AU - Bisgaard, H

AU - Pennell, CE

AU - Jaddoe, Vincent

AU - Dedoussis, G

AU - Timpson, N

AU - Zeggini, E

AU - Vitart, V

AU - St Pourcain, B

PY - 2019

Y1 - 2019

U2 - 10.1038/s41467-018-07863-x

DO - 10.1038/s41467-018-07863-x

M3 - Article

C2 - 30664637

SN - 2041-1723

VL - 10

JO - Nature Communications

JF - Nature Communications

M1 - 357

ER -