Low molecular weight protein tyrosine phosphatase as signaling hub of cancer hallmarks

Alessandra V.S. Faria; Emanuella Maria Barreto Fonseca; Helon Guimarães Cordeiro; Stefano Piatto Clerici; Carmen Veríssima Ferreira-Halder

doi:10.1007/s00018-020-03657-x

Low molecular weight protein tyrosine phosphatase as signaling hub of cancer hallmarks

Alessandra V.S. Faria
, Emanuella Maria Barreto Fonseca
, Helon Guimarães Cordeiro
, Stefano Piatto Clerici
, Carmen Veríssima Ferreira-Halder^*

^*Corresponding author for this work

Gastroenterology & Hepatology

Universidade Estadual de Campinas
Federal Institute of São Paulo

Research output: Contribution to journal › Review article › Professional › peer-review

9 Citations (Scopus)

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Abstract

In the past decade, significant progress has been made in understanding the role of protein tyrosine phosphatase as a positive regulator of tumor progression. In this scenario, our group was one of the first to report the involvement of the low molecular weight protein tyrosine phosphatase (LMWPTP or ACP1) in the process of resistance and migration of tumor cells. Later, we and others demonstrated a positive correlation between the amount of this enzyme in human tumors and the poor prognosis. With this information in mind, we asked if LMWPTP contribution to metastasis, would it have an action beyond the primary tumor site. We know that the amount of this enzyme in the tumor cell correlates positively with the ability of cancer cells to interact with platelets, an indication that this enzyme is also important for the survival of these cells in the bloodstream. Here, we discuss several molecular aspects that support the idea of LMWPTP as a signaling hub of cancer hallmarks. Chemical and genetic modulation of LMWPTP proved to shut down signaling pathways associated with cancer aggressiveness. Therefore, advances in the development of LMWPTP inhibitors have great applicability in human diseases such as cancer.

Original language	English
Pages (from-to)	1263-1273
Number of pages	11
Journal	Cellular and Molecular Life Sciences
Volume	78
Issue number	4
Early online date	14 Oct 2020
DOIs	https://doi.org/10.1007/s00018-020-03657-x
Publication status	Published - Feb 2021

Bibliographical note

Funding Information:
The study of LMWPTP in cancer biology was supported by the São Paulo Research Foundation under grants SPC (2018/03593-6), AVSF (2017/08119-8), EMBF (2015/11433-0), CVFH (2015/20412-7), National Council for Scientific and Technological Development (CNPq)—Brazil under grants: 141723/2019–0 (HGC) and 303900/2017-2 (CVFH) and the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior—Brasil (CAPES)—Finance Code 001. Acknowledgements

Publisher Copyright:
© 2020, Springer Nature Switzerland AG.

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Low molecular weight protein tyrosine phosphatase as signaling hub of cancer hallmarksFinal published version, 1.09 MBLicence: CC BY

Cite this

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title = "Low molecular weight protein tyrosine phosphatase as signaling hub of cancer hallmarks",

abstract = "In the past decade, significant progress has been made in understanding the role of protein tyrosine phosphatase as a positive regulator of tumor progression. In this scenario, our group was one of the first to report the involvement of the low molecular weight protein tyrosine phosphatase (LMWPTP or ACP1) in the process of resistance and migration of tumor cells. Later, we and others demonstrated a positive correlation between the amount of this enzyme in human tumors and the poor prognosis. With this information in mind, we asked if LMWPTP contribution to metastasis, would it have an action beyond the primary tumor site. We know that the amount of this enzyme in the tumor cell correlates positively with the ability of cancer cells to interact with platelets, an indication that this enzyme is also important for the survival of these cells in the bloodstream. Here, we discuss several molecular aspects that support the idea of LMWPTP as a signaling hub of cancer hallmarks. Chemical and genetic modulation of LMWPTP proved to shut down signaling pathways associated with cancer aggressiveness. Therefore, advances in the development of LMWPTP inhibitors have great applicability in human diseases such as cancer.",

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note = "Funding Information: The study of LMWPTP in cancer biology was supported by the S{\~a}o Paulo Research Foundation under grants SPC (2018/03593-6), AVSF (2017/08119-8), EMBF (2015/11433-0), CVFH (2015/20412-7), National Council for Scientific and Technological Development (CNPq)—Brazil under grants: 141723/2019–0 (HGC) and 303900/2017-2 (CVFH) and the Coordena{\c c}{\~a}o de Aperfei{\c c}oamento de Pessoal de N{\'i}vel Superior—Brasil (CAPES)—Finance Code 001. Acknowledgements Publisher Copyright: {\textcopyright} 2020, Springer Nature Switzerland AG.",

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AU - Clerici, Stefano Piatto

AU - Ferreira-Halder, Carmen Veríssima

N1 - Funding Information: The study of LMWPTP in cancer biology was supported by the São Paulo Research Foundation under grants SPC (2018/03593-6), AVSF (2017/08119-8), EMBF (2015/11433-0), CVFH (2015/20412-7), National Council for Scientific and Technological Development (CNPq)—Brazil under grants: 141723/2019–0 (HGC) and 303900/2017-2 (CVFH) and the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior—Brasil (CAPES)—Finance Code 001. Acknowledgements Publisher Copyright: © 2020, Springer Nature Switzerland AG.

PY - 2021/2

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N2 - In the past decade, significant progress has been made in understanding the role of protein tyrosine phosphatase as a positive regulator of tumor progression. In this scenario, our group was one of the first to report the involvement of the low molecular weight protein tyrosine phosphatase (LMWPTP or ACP1) in the process of resistance and migration of tumor cells. Later, we and others demonstrated a positive correlation between the amount of this enzyme in human tumors and the poor prognosis. With this information in mind, we asked if LMWPTP contribution to metastasis, would it have an action beyond the primary tumor site. We know that the amount of this enzyme in the tumor cell correlates positively with the ability of cancer cells to interact with platelets, an indication that this enzyme is also important for the survival of these cells in the bloodstream. Here, we discuss several molecular aspects that support the idea of LMWPTP as a signaling hub of cancer hallmarks. Chemical and genetic modulation of LMWPTP proved to shut down signaling pathways associated with cancer aggressiveness. Therefore, advances in the development of LMWPTP inhibitors have great applicability in human diseases such as cancer.

AB - In the past decade, significant progress has been made in understanding the role of protein tyrosine phosphatase as a positive regulator of tumor progression. In this scenario, our group was one of the first to report the involvement of the low molecular weight protein tyrosine phosphatase (LMWPTP or ACP1) in the process of resistance and migration of tumor cells. Later, we and others demonstrated a positive correlation between the amount of this enzyme in human tumors and the poor prognosis. With this information in mind, we asked if LMWPTP contribution to metastasis, would it have an action beyond the primary tumor site. We know that the amount of this enzyme in the tumor cell correlates positively with the ability of cancer cells to interact with platelets, an indication that this enzyme is also important for the survival of these cells in the bloodstream. Here, we discuss several molecular aspects that support the idea of LMWPTP as a signaling hub of cancer hallmarks. Chemical and genetic modulation of LMWPTP proved to shut down signaling pathways associated with cancer aggressiveness. Therefore, advances in the development of LMWPTP inhibitors have great applicability in human diseases such as cancer.

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ER -

Low molecular weight protein tyrosine phosphatase as signaling hub of cancer hallmarks

Abstract

Bibliographical note

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