Lower atovaquone/proguanil concentrations in patients taking efavirenz, lopinavir/ritonavir or atazanavir/ritonavir

M van Luin; Marchina Ende; C Richter; Martje Visser; D Faraj; A van de Ven; Luc Gelinck; F Kroon; FW Wit; Ron van Schaik; PFM Kuks; DM Burger

doi:10.1097/QAD.0b013e3283389129

Lower atovaquone/proguanil concentrations in patients taking efavirenz, lopinavir/ritonavir or atazanavir/ritonavir

M van Luin, Marchina Ende, C Richter, Martje Visser, D Faraj, A van de Ven, Luc Gelinck, F Kroon, FW Wit, Ron van Schaik, PFM Kuks, DM Burger

Research output: Contribution to journal › Article › Academic › peer-review

37 Citations (Scopus)

Abstract

HIV-infected travellers frequently use atovaquone/ proguanil as malaria prophylaxis. We compared atovaquone/ proguanil pharmacokinetics between healthy volunteers and HIV-infected patients taking efavirenz, lopinavir/ ritonavir or atazanavir/ritonavir. The geometric mean ratio (95% confidence interval) area under the curve (AUC)(0 -> t) for atovaquone relative to the healthy volunteers was 0.25 (0.16-0.38), 0.26 (0.17-0.41) and 0.54 (0.350.83) for patients on efavirenz, lopinavir/ ritonavir and atazanavir/ ritonavir, respectively. Proguanil plasma concentrations were also significantly lower (38-43%). Physicians should be alert for atovaquone/ proguanil prophylaxis failures in patients taking efavirenz, lopinavir/ ritonavir or atazanavir/ ritonavir.

Original language	Undefined/Unknown
Pages (from-to)	1223-1226
Number of pages	4
Journal	AIDS
Volume	24
Issue number	8
DOIs	https://doi.org/10.1097/QAD.0b013e3283389129
Publication status	Published - 2010

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10.1097/QAD.0b013e3283389129

http://hdl.handle.net/1765/27864

Cite this

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title = "Lower atovaquone/proguanil concentrations in patients taking efavirenz, lopinavir/ritonavir or atazanavir/ritonavir",

abstract = "HIV-infected travellers frequently use atovaquone/ proguanil as malaria prophylaxis. We compared atovaquone/ proguanil pharmacokinetics between healthy volunteers and HIV-infected patients taking efavirenz, lopinavir/ ritonavir or atazanavir/ritonavir. The geometric mean ratio (95% confidence interval) area under the curve (AUC)(0 -> t) for atovaquone relative to the healthy volunteers was 0.25 (0.16-0.38), 0.26 (0.17-0.41) and 0.54 (0.350.83) for patients on efavirenz, lopinavir/ ritonavir and atazanavir/ ritonavir, respectively. Proguanil plasma concentrations were also significantly lower (38-43%). Physicians should be alert for atovaquone/ proguanil prophylaxis failures in patients taking efavirenz, lopinavir/ ritonavir or atazanavir/ ritonavir.",

author = "{van Luin}, M and Marchina Ende and C Richter and Martje Visser and D Faraj and {van de Ven}, A and Luc Gelinck and F Kroon and FW Wit and {van Schaik}, Ron and PFM Kuks and DM Burger",

year = "2010",

doi = "10.1097/QAD.0b013e3283389129",

language = "Undefined/Unknown",

volume = "24",

pages = "1223--1226",

journal = "AIDS",

issn = "0269-9370",

publisher = "Lippincott Williams & Wilkins",

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TY - JOUR

T1 - Lower atovaquone/proguanil concentrations in patients taking efavirenz, lopinavir/ritonavir or atazanavir/ritonavir

AU - van Luin, M

AU - Ende, Marchina

AU - Richter, C

AU - Visser, Martje

AU - Faraj, D

AU - van de Ven, A

AU - Gelinck, Luc

AU - Kroon, F

AU - Wit, FW

AU - van Schaik, Ron

AU - Kuks, PFM

AU - Burger, DM

PY - 2010

Y1 - 2010

N2 - HIV-infected travellers frequently use atovaquone/ proguanil as malaria prophylaxis. We compared atovaquone/ proguanil pharmacokinetics between healthy volunteers and HIV-infected patients taking efavirenz, lopinavir/ ritonavir or atazanavir/ritonavir. The geometric mean ratio (95% confidence interval) area under the curve (AUC)(0 -> t) for atovaquone relative to the healthy volunteers was 0.25 (0.16-0.38), 0.26 (0.17-0.41) and 0.54 (0.350.83) for patients on efavirenz, lopinavir/ ritonavir and atazanavir/ ritonavir, respectively. Proguanil plasma concentrations were also significantly lower (38-43%). Physicians should be alert for atovaquone/ proguanil prophylaxis failures in patients taking efavirenz, lopinavir/ ritonavir or atazanavir/ ritonavir.

AB - HIV-infected travellers frequently use atovaquone/ proguanil as malaria prophylaxis. We compared atovaquone/ proguanil pharmacokinetics between healthy volunteers and HIV-infected patients taking efavirenz, lopinavir/ ritonavir or atazanavir/ritonavir. The geometric mean ratio (95% confidence interval) area under the curve (AUC)(0 -> t) for atovaquone relative to the healthy volunteers was 0.25 (0.16-0.38), 0.26 (0.17-0.41) and 0.54 (0.350.83) for patients on efavirenz, lopinavir/ ritonavir and atazanavir/ ritonavir, respectively. Proguanil plasma concentrations were also significantly lower (38-43%). Physicians should be alert for atovaquone/ proguanil prophylaxis failures in patients taking efavirenz, lopinavir/ ritonavir or atazanavir/ ritonavir.

U2 - 10.1097/QAD.0b013e3283389129

DO - 10.1097/QAD.0b013e3283389129

M3 - Article

C2 - 20299957

SN - 0269-9370

VL - 24

SP - 1223

EP - 1226

JO - AIDS

JF - AIDS

IS - 8

ER -