Macrophage progenitors from mouse bone marrow and spleen differ in their expression of the Ly-6C differentiation antigen

J. M. McCormack; P. J.M. Leenen; W. S. Walker

Macrophage progenitors from mouse bone marrow and spleen differ in their expression of the Ly-6C differentiation antigen

J. M. McCormack
, P. J.M. Leenen
, W. S. Walker^*

^*Corresponding author for this work

St. Jude Children Research Hospital

Research output: Contribution to journal › Article › Academic › peer-review

36 Citations (Scopus)

Abstract

Using mAb and magnetic and fluorescence-activated cell sorting, together with culturing in semisolid culture medium, we show that essentially all splenic macrophage progenitors are Ly-6C(hi)Mac-1^-. By contrast, bone marrow macrophage progenitors were more heterogeneous in Ly-6C expression, the majority being restricted to the Ly-6C(dim)Mac-1^- and the Ly-6C^-Mac-1^- subsets. These findings provide immunophenotype evidence that macrophages in the spleen and bone marrow arise from different progenitors.

Original language	English
Pages (from-to)	6389-6398
Number of pages	10
Journal	Journal of Immunology
Volume	151
Issue number	11
Publication status	Published - 1 Dec 1993
Externally published	Yes

Cite this

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abstract = "Using mAb and magnetic and fluorescence-activated cell sorting, together with culturing in semisolid culture medium, we show that essentially all splenic macrophage progenitors are Ly-6C(hi)Mac-1-. By contrast, bone marrow macrophage progenitors were more heterogeneous in Ly-6C expression, the majority being restricted to the Ly-6C(dim)Mac-1- and the Ly-6C-Mac-1- subsets. These findings provide immunophenotype evidence that macrophages in the spleen and bone marrow arise from different progenitors.",

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T1 - Macrophage progenitors from mouse bone marrow and spleen differ in their expression of the Ly-6C differentiation antigen

AU - McCormack, J. M.

AU - Leenen, P. J.M.

AU - Walker, W. S.

PY - 1993/12/1

Y1 - 1993/12/1

N2 - Using mAb and magnetic and fluorescence-activated cell sorting, together with culturing in semisolid culture medium, we show that essentially all splenic macrophage progenitors are Ly-6C(hi)Mac-1-. By contrast, bone marrow macrophage progenitors were more heterogeneous in Ly-6C expression, the majority being restricted to the Ly-6C(dim)Mac-1- and the Ly-6C-Mac-1- subsets. These findings provide immunophenotype evidence that macrophages in the spleen and bone marrow arise from different progenitors.

AB - Using mAb and magnetic and fluorescence-activated cell sorting, together with culturing in semisolid culture medium, we show that essentially all splenic macrophage progenitors are Ly-6C(hi)Mac-1-. By contrast, bone marrow macrophage progenitors were more heterogeneous in Ly-6C expression, the majority being restricted to the Ly-6C(dim)Mac-1- and the Ly-6C-Mac-1- subsets. These findings provide immunophenotype evidence that macrophages in the spleen and bone marrow arise from different progenitors.

UR - https://www.scopus.com/pages/publications/0027369370

M3 - Article

C2 - 8245473

AN - SCOPUS:0027369370

SN - 0022-1767

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JO - Journal of Immunology

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IS - 11

ER -

Macrophage progenitors from mouse bone marrow and spleen differ in their expression of the Ly-6C differentiation antigen

Abstract

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