Magnetic Resonance Imaging compatible Elastic Loading Mechanism (MELM): A minimal footprint device for MR imaging under load

Jaap Boon, Telly Ploem, Cole S. Simpson, Ingo Hermann, Mehmet Akcakaya, Edwin H. Oei, Amir A. Zadpoor, Nazli Tumer, Tom M. Piscaer, Joao Tourais, Sebastian Weingartner

Research output: Chapter/Conference proceedingConference proceedingAcademicpeer-review

Abstract

Quantitative Magnetic Resonance Imaging (MRI) can enable early diagnosis of knee cartilage damage if imaging is performed during the application of load. Mechanical loading via ropes, pulleys and suspended weights can be obstructive and require adaptations to the patient table. In this paper, a new lightweight MRI-compatible elastic loading mechanism is introduced. The new device showed sufficient linearity (|α/β| = 0.42 ± 0.25), reproducibility (CoV = 5 ± 2%), and stability (CoV = 0.5 ± 0.1%). In vivo and ex vivo scans confirmed the ability of the device to exert sufficient force to study the knee cartilage under loading conditions, inducing up to a 29% decrease in T2 of the central medial cartilage. With this device mechanical loading can become more accessible for researchers and clinicians, thus facilitating the translational use of MRI biomarkers for the detection of cartilage deterioration.

Original languageEnglish
Title of host publication43rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2021
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages3721-3724
Number of pages4
ISBN (Electronic)9781728111797
DOIs
Publication statusPublished - 2021
Event43rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2021 - Virtual, Online, Mexico
Duration: 1 Nov 20215 Nov 2021

Publication series

SeriesProceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
ISSN1557-170X

Conference

Conference43rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2021
Country/TerritoryMexico
CityVirtual, Online
Period1/11/215/11/21

Bibliographical note

Funding Information:
This study was approved by the Human Research Ethics Committee of the TU Delft

Publisher Copyright:
© 2021 IEEE.

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