Magnetic Resonance Imaging compatible Elastic Loading Mechanism (MELM): A minimal footprint device for MR imaging under load

Jaap Boon; Telly Ploem; Cole S. Simpson; Ingo Hermann; Mehmet Akcakaya; Edwin H. Oei; Amir A. Zadpoor; Nazli Tumer; Tom M. Piscaer; Joao Tourais; Sebastian Weingartner

doi:10.1109/EMBC46164.2021.9630397

Magnetic Resonance Imaging compatible Elastic Loading Mechanism (MELM): A minimal footprint device for MR imaging under load

Jaap Boon, Telly Ploem, Cole S. Simpson, Ingo Hermann, Mehmet Akcakaya, Edwin H. Oei, Amir A. Zadpoor, Nazli Tumer, Tom M. Piscaer, Joao Tourais, Sebastian Weingartner

Research output: Chapter/Conference proceeding › Conference proceeding › Academic › peer-review

1 Citation (Scopus)

Abstract

Quantitative Magnetic Resonance Imaging (MRI) can enable early diagnosis of knee cartilage damage if imaging is performed during the application of load. Mechanical loading via ropes, pulleys and suspended weights can be obstructive and require adaptations to the patient table. In this paper, a new lightweight MRI-compatible elastic loading mechanism is introduced. The new device showed sufficient linearity (|α/β| = 0.42 ± 0.25), reproducibility (CoV = 5 ± 2%), and stability (CoV = 0.5 ± 0.1%). In vivo and ex vivo scans confirmed the ability of the device to exert sufficient force to study the knee cartilage under loading conditions, inducing up to a 29% decrease in T2 of the central medial cartilage. With this device mechanical loading can become more accessible for researchers and clinicians, thus facilitating the translational use of MRI biomarkers for the detection of cartilage deterioration.

Original language	English
Title of host publication	43rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2021
Publisher	Institute of Electrical and Electronics Engineers Inc.
Pages	3721-3724
Number of pages	4
ISBN (Electronic)	9781728111797
DOIs	https://doi.org/10.1109/EMBC46164.2021.9630397
Publication status	Published - 2021
Event	43rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2021 - Virtual, Online, Mexico Duration: 1 Nov 2021 → 5 Nov 2021

Publication series

Series	Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
ISSN	1557-170X

Conference

Conference	43rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2021
Country/Territory	Mexico
City	Virtual, Online
Period	1/11/21 → 5/11/21

Bibliographical note

Funding Information:
This study was approved by the Human Research Ethics Committee of the TU Delft

Publisher Copyright:
© 2021 IEEE.

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10.1109/EMBC46164.2021.9630397

Cite this

Boon, J., Ploem, T., Simpson, C. S., Hermann, I., Akcakaya, M., Oei, E. H., Zadpoor, A. A., Tumer, N., Piscaer, T. M., Tourais, J., & Weingartner, S. (2021). Magnetic Resonance Imaging compatible Elastic Loading Mechanism (MELM): A minimal footprint device for MR imaging under load. In 43rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2021 (pp. 3721-3724). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/EMBC46164.2021.9630397

Boon, Jaap ; Ploem, Telly ; Simpson, Cole S. et al. / Magnetic Resonance Imaging compatible Elastic Loading Mechanism (MELM) : A minimal footprint device for MR imaging under load. 43rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2021. Institute of Electrical and Electronics Engineers Inc., 2021. pp. 3721-3724 (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS).

@inproceedings{76a0c8610c5d459ea8184f09de02ca98,

title = "Magnetic Resonance Imaging compatible Elastic Loading Mechanism (MELM): A minimal footprint device for MR imaging under load",

abstract = "Quantitative Magnetic Resonance Imaging (MRI) can enable early diagnosis of knee cartilage damage if imaging is performed during the application of load. Mechanical loading via ropes, pulleys and suspended weights can be obstructive and require adaptations to the patient table. In this paper, a new lightweight MRI-compatible elastic loading mechanism is introduced. The new device showed sufficient linearity (|α/β| = 0.42 ± 0.25), reproducibility (CoV = 5 ± 2%), and stability (CoV = 0.5 ± 0.1%). In vivo and ex vivo scans confirmed the ability of the device to exert sufficient force to study the knee cartilage under loading conditions, inducing up to a 29% decrease in T2 of the central medial cartilage. With this device mechanical loading can become more accessible for researchers and clinicians, thus facilitating the translational use of MRI biomarkers for the detection of cartilage deterioration.",

author = "Jaap Boon and Telly Ploem and Simpson, {Cole S.} and Ingo Hermann and Mehmet Akcakaya and Oei, {Edwin H.} and Zadpoor, {Amir A.} and Nazli Tumer and Piscaer, {Tom M.} and Joao Tourais and Sebastian Weingartner",

note = "Funding Information: This study was approved by the Human Research Ethics Committee of the TU Delft Publisher Copyright: {\textcopyright} 2021 IEEE.; 43rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2021 ; Conference date: 01-11-2021 Through 05-11-2021",

year = "2021",

doi = "10.1109/EMBC46164.2021.9630397",

language = "English",

series = "Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS",

publisher = "Institute of Electrical and Electronics Engineers Inc.",

pages = "3721--3724",

booktitle = "43rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2021",

address = "United States",

}

Boon, J, Ploem, T, Simpson, CS, Hermann, I, Akcakaya, M, Oei, EH, Zadpoor, AA, Tumer, N, Piscaer, TM, Tourais, J & Weingartner, S 2021, Magnetic Resonance Imaging compatible Elastic Loading Mechanism (MELM): A minimal footprint device for MR imaging under load. in 43rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2021. Institute of Electrical and Electronics Engineers Inc., Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS, pp. 3721-3724, 43rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2021, Virtual, Online, Mexico, 1/11/21. https://doi.org/10.1109/EMBC46164.2021.9630397

Magnetic Resonance Imaging compatible Elastic Loading Mechanism (MELM): A minimal footprint device for MR imaging under load. / Boon, Jaap; Ploem, Telly; Simpson, Cole S. et al.
43rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2021. Institute of Electrical and Electronics Engineers Inc., 2021. p. 3721-3724 (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS).

Research output: Chapter/Conference proceeding › Conference proceeding › Academic › peer-review

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T1 - Magnetic Resonance Imaging compatible Elastic Loading Mechanism (MELM)

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AU - Boon, Jaap

AU - Ploem, Telly

AU - Simpson, Cole S.

AU - Hermann, Ingo

AU - Akcakaya, Mehmet

AU - Oei, Edwin H.

AU - Zadpoor, Amir A.

AU - Tumer, Nazli

AU - Piscaer, Tom M.

AU - Tourais, Joao

AU - Weingartner, Sebastian

PY - 2021

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N2 - Quantitative Magnetic Resonance Imaging (MRI) can enable early diagnosis of knee cartilage damage if imaging is performed during the application of load. Mechanical loading via ropes, pulleys and suspended weights can be obstructive and require adaptations to the patient table. In this paper, a new lightweight MRI-compatible elastic loading mechanism is introduced. The new device showed sufficient linearity (|α/β| = 0.42 ± 0.25), reproducibility (CoV = 5 ± 2%), and stability (CoV = 0.5 ± 0.1%). In vivo and ex vivo scans confirmed the ability of the device to exert sufficient force to study the knee cartilage under loading conditions, inducing up to a 29% decrease in T2 of the central medial cartilage. With this device mechanical loading can become more accessible for researchers and clinicians, thus facilitating the translational use of MRI biomarkers for the detection of cartilage deterioration.

AB - Quantitative Magnetic Resonance Imaging (MRI) can enable early diagnosis of knee cartilage damage if imaging is performed during the application of load. Mechanical loading via ropes, pulleys and suspended weights can be obstructive and require adaptations to the patient table. In this paper, a new lightweight MRI-compatible elastic loading mechanism is introduced. The new device showed sufficient linearity (|α/β| = 0.42 ± 0.25), reproducibility (CoV = 5 ± 2%), and stability (CoV = 0.5 ± 0.1%). In vivo and ex vivo scans confirmed the ability of the device to exert sufficient force to study the knee cartilage under loading conditions, inducing up to a 29% decrease in T2 of the central medial cartilage. With this device mechanical loading can become more accessible for researchers and clinicians, thus facilitating the translational use of MRI biomarkers for the detection of cartilage deterioration.

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AN - SCOPUS:85122538225

T3 - Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS

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BT - 43rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2021

PB - Institute of Electrical and Electronics Engineers Inc.

Y2 - 1 November 2021 through 5 November 2021

ER -

Boon J, Ploem T, Simpson CS, Hermann I, Akcakaya M, Oei EH et al. Magnetic Resonance Imaging compatible Elastic Loading Mechanism (MELM): A minimal footprint device for MR imaging under load. In 43rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2021. Institute of Electrical and Electronics Engineers Inc. 2021. p. 3721-3724. (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS). doi: 10.1109/EMBC46164.2021.9630397

Magnetic Resonance Imaging compatible Elastic Loading Mechanism (MELM): A minimal footprint device for MR imaging under load

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