Magnetic Resonance Imaging–Defined Osteoarthritis Features and Anterior Knee Pain in Individuals With, or at Risk for, Knee Osteoarthritis: A Multicenter Study on Osteoarthritis

Erin M Macri, Tuhina Neogi, Mohamed Jarraya, Ali Guermazi, Frank Roemer, Cora E Lewis, James C Torner, John A Lynch, Irina Tolstykh, S Reza Jafarzadeh, Joshua J Stefanik*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

10 Citations (Scopus)

Abstract

Objective: The lack of strong association between knee osteoarthritis (OA) structural features and pain continues to perplex researchers and clinicians. Evaluating the patellofemoral joint in addition to the tibiofemoral joint alone has contributed to explaining this structure–pain discordance, hence justifying a more comprehensive evaluation of whole-knee OA and pain. The present study, therefore, was undertaken to evaluate the association between patellofemoral and tibiofemoral OA features with localized anterior knee pain (AKP) using 2 study designs. Methods: Using cross-sectional data from the Multicenter Osteoarthritis Study, our first approach was a within-person, knee-matched design in which we identified participants with unilateral AKP. We then assessed magnetic resonance imaging (MRI)–derived OA features (cartilage damage, bone marrow lesions [BMLs], osteophytes, and inflammation) in both knees and evaluated the association of patellofemoral and tibiofemoral OA features to unilateral AKP. In our second approach, MRIs from 1 knee per person were scored, and we evaluated the association of OA features to AKP in participants with AKP and participants with no frequent knee pain. Results: Using the first approach (n = 71, 66% women, mean ± SD age 69 ± 8 years), lateral patellofemoral osteophytes (odds ratio [OR] 5.0 [95% confidence interval (95% CI) 1.7–14.6]), whole-knee joint effusion-synovitis (OR 4.7 [95% CI 1.3–16.2]), and infrapatellar synovitis (OR 2.8 [95% CI 1.0–7.8]) were associated with AKP. Using the second approach (n = 882, 59% women, mean ± SD age 69 ± 7 years), lateral and medial patellofemoral cartilage damage (prevalence ratio [PR] 2.3 [95% CI 1.3–4.0] and PR 1.9 [95% CI 1.1–3.3], respectively) and lateral patellofemoral BMLs (PR 2.6 [95% CI 1.5–4.7]) were associated with AKP. Conclusion: Patellofemoral but not tibiofemoral joint OA features and inflammation were associated with AKP.

Original languageEnglish
JournalArthritis Care and Research
Early online date25 Mar 2021
DOIs
Publication statusPublished - 25 Mar 2021

Bibliographical note

Funding Information:
The Multicenter Osteoarthritis Study was funded by the NIH (grants U01‐AG‐18820, U01‐AG‐18832, U01‐AG‐18947, U01‐AG‐19069, and P60‐AR‐47785). Dr. Macri's work was supported by the NIH (National Institute of General Medical Sciences grant U54‐GM‐104941) and the CIHR (Banting Postdoctoral fellowship). Dr. Neogi's work was supported by the NIH (grants K24‐AR‐070892, P60‐AR‐047785, R01‐AR‐062506, P30‐AR‐072571, and R01‐AG‐066010). Dr. Stefanik's work was supported by the NIH (National Institute of General Medical Sciences grants U54‐GM‐104941 and K23‐AR‐070913).

Publisher Copyright:
© 2021 The Authors. Arthritis Care & Research published by Wiley Periodicals LLC on behalf of American College of Rheumatology.

Fingerprint

Dive into the research topics of 'Magnetic Resonance Imaging–Defined Osteoarthritis Features and Anterior Knee Pain in Individuals With, or at Risk for, Knee Osteoarthritis: A Multicenter Study on Osteoarthritis'. Together they form a unique fingerprint.

Cite this