Malignant transformation in sacrococcygeal teratoma and in presacral teratoma associated with Currarino syndrome: A comparative study

M Dirix; T van Becelaere; L Berkenbosch; R van Baren; Rene Wijnen; MH Wijnen; DC van der Zee; HA Heij; JPM Derikx; LWE van Heurn

doi:10.1016/j.jpedsurg.2014.07.014

Malignant transformation in sacrococcygeal teratoma and in presacral teratoma associated with Currarino syndrome: A comparative study

M Dirix, T van Becelaere, L Berkenbosch, R van Baren, Rene Wijnen, MH Wijnen, DC van der Zee, HA Heij, JPM Derikx, LWE van Heurn

Pediatric Surgery

Research output: Contribution to journal › Article › Academic › peer-review

32 Citations (Scopus)

Abstract

Background/purpose: The risk of malignant transformation of sacrococcygeal teratoma (SCT) and of presacral teratoma in Currarino syndrome (CS) may differ despite the similar position and appearance. Methods: Malignant transformation and teratoma recurrence were assessed in a national retrospective comparative analysis of 205 SCT and 16 CS patients treated in one of the six pediatric surgical centers in the Netherlands between January 1981 and December 2010. Results: The malignancy free survival of patients with SCT was lower than for patients with a presacral teratoma associated with CS (80% and 58% after one and two years in SCT versus 100% after two years in CS, p = 0.017) Conclusions: In SCT, malignancy and recurrence risk are high. Therefore, early and complete resection is mandatory. Our data show that the risk of malignant transformation of a presacral teratoma in CS is small. (C) 2015 Elsevier Inc. All rights reserved.

Original language	Undefined/Unknown
Pages (from-to)	462-464
Number of pages	3
Journal	Journal of Pediatric Surgery
Volume	50
Issue number	3
DOIs	https://doi.org/10.1016/j.jpedsurg.2014.07.014
Publication status	Published - 2015

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10.1016/j.jpedsurg.2014.07.014

http://hdl.handle.net/1765/85155

Cite this

Dirix, M., van Becelaere, T., Berkenbosch, L., van Baren, R., Wijnen, R., Wijnen, MH., van der Zee, DC., Heij, HA., Derikx, JPM., & van Heurn, LWE. (2015). Malignant transformation in sacrococcygeal teratoma and in presacral teratoma associated with Currarino syndrome: A comparative study. Journal of Pediatric Surgery, 50(3), 462-464. https://doi.org/10.1016/j.jpedsurg.2014.07.014

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abstract = "Background/purpose: The risk of malignant transformation of sacrococcygeal teratoma (SCT) and of presacral teratoma in Currarino syndrome (CS) may differ despite the similar position and appearance. Methods: Malignant transformation and teratoma recurrence were assessed in a national retrospective comparative analysis of 205 SCT and 16 CS patients treated in one of the six pediatric surgical centers in the Netherlands between January 1981 and December 2010. Results: The malignancy free survival of patients with SCT was lower than for patients with a presacral teratoma associated with CS (80% and 58% after one and two years in SCT versus 100% after two years in CS, p = 0.017) Conclusions: In SCT, malignancy and recurrence risk are high. Therefore, early and complete resection is mandatory. Our data show that the risk of malignant transformation of a presacral teratoma in CS is small. (C) 2015 Elsevier Inc. All rights reserved.",

author = "M Dirix and {van Becelaere}, T and L Berkenbosch and {van Baren}, R and Rene Wijnen and MH Wijnen and {van der Zee}, DC and HA Heij and JPM Derikx and {van Heurn}, LWE",

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Dirix, M, van Becelaere, T, Berkenbosch, L, van Baren, R, Wijnen, R, Wijnen, MH, van der Zee, DC, Heij, HA, Derikx, JPM & van Heurn, LWE 2015, 'Malignant transformation in sacrococcygeal teratoma and in presacral teratoma associated with Currarino syndrome: A comparative study', Journal of Pediatric Surgery, vol. 50, no. 3, pp. 462-464. https://doi.org/10.1016/j.jpedsurg.2014.07.014

TY - JOUR

T1 - Malignant transformation in sacrococcygeal teratoma and in presacral teratoma associated with Currarino syndrome: A comparative study

AU - Dirix, M

AU - van Becelaere, T

AU - Berkenbosch, L

AU - van Baren, R

AU - Wijnen, Rene

AU - Wijnen, MH

AU - van der Zee, DC

AU - Heij, HA

AU - Derikx, JPM

AU - van Heurn, LWE

PY - 2015

Y1 - 2015

N2 - Background/purpose: The risk of malignant transformation of sacrococcygeal teratoma (SCT) and of presacral teratoma in Currarino syndrome (CS) may differ despite the similar position and appearance. Methods: Malignant transformation and teratoma recurrence were assessed in a national retrospective comparative analysis of 205 SCT and 16 CS patients treated in one of the six pediatric surgical centers in the Netherlands between January 1981 and December 2010. Results: The malignancy free survival of patients with SCT was lower than for patients with a presacral teratoma associated with CS (80% and 58% after one and two years in SCT versus 100% after two years in CS, p = 0.017) Conclusions: In SCT, malignancy and recurrence risk are high. Therefore, early and complete resection is mandatory. Our data show that the risk of malignant transformation of a presacral teratoma in CS is small. (C) 2015 Elsevier Inc. All rights reserved.

AB - Background/purpose: The risk of malignant transformation of sacrococcygeal teratoma (SCT) and of presacral teratoma in Currarino syndrome (CS) may differ despite the similar position and appearance. Methods: Malignant transformation and teratoma recurrence were assessed in a national retrospective comparative analysis of 205 SCT and 16 CS patients treated in one of the six pediatric surgical centers in the Netherlands between January 1981 and December 2010. Results: The malignancy free survival of patients with SCT was lower than for patients with a presacral teratoma associated with CS (80% and 58% after one and two years in SCT versus 100% after two years in CS, p = 0.017) Conclusions: In SCT, malignancy and recurrence risk are high. Therefore, early and complete resection is mandatory. Our data show that the risk of malignant transformation of a presacral teratoma in CS is small. (C) 2015 Elsevier Inc. All rights reserved.

U2 - 10.1016/j.jpedsurg.2014.07.014

DO - 10.1016/j.jpedsurg.2014.07.014

M3 - Article

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