Mapping SARS-CoV-2 antigenic relationships and serological responses

Samuel H. Wilks; Barbara Mühlemann; Xiaoying Shen; Sina Türeli; Eric B. LeGresley; Antonia Netzl; Miguela A. Caniza; Jesus N. Chacaltana-Huarcaya; Victor M. Corman; Xiaoju Daniell; Michael B. Datto; Fatimah S. Dawood; Thomas N. Denny; Christian Drosten; Ron A.M. Fouchier; Patricia J. Garcia; Peter J. Halfmann; Agatha Jassem; Lara M. Jeworowski; Terry C. Jones; Yoshihiro Kawaoka; Florian Krammer; Charlene McDanal; Rolando Pajon; Viviana Simon; Melissa S. Stockwell; Haili Tang; Harm van Bakel; Vic Veguilla; Richard Webby; David C. Montefiori; Derek J. Smith

doi:10.1126/science.adj0070

Mapping SARS-CoV-2 antigenic relationships and serological responses

Samuel H. Wilks^*
, Barbara Mühlemann
, Xiaoying Shen
, Sina Türeli
, Eric B. LeGresley
, Antonia Netzl
, Miguela A. Caniza
, Jesus N. Chacaltana-Huarcaya
, Victor M. Corman
, Xiaoju Daniell
, Michael B. Datto
, Fatimah S. Dawood
, Thomas N. Denny
, Christian Drosten
, Ron A.M. Fouchier
, Patricia J. Garcia
, Peter J. Halfmann
, Agatha Jassem
, Lara M. Jeworowski
, Terry C. Jones

Yoshihiro Kawaoka, Florian Krammer, Charlene McDanal, Rolando Pajon, Viviana Simon, Melissa S. Stockwell, Haili Tang, Harm van Bakel, Vic Veguilla, Richard Webby, David C. Montefiori^*, Derek J. Smith^*

^*Corresponding author for this work

Virology

Research output: Contribution to journal › Article › Academic › peer-review

59 Citations (Scopus)

Abstract

During the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, multiple variants escaping preexisting immunity emerged, causing reinfections of previously exposed individuals. Here, we used antigenic cartography to analyze patterns of cross-reactivity among 21 variants and 15 groups of human sera obtained after primary infection with 10 different variants or after messenger RNA (mRNA)–1273 or mRNA-1273.351 vaccination. We found antigenic differences among pre-Omicron variants caused by substitutions at spike-protein positions 417, 452, 484, and 501. Quantifying changes in response breadth over time and with additional vaccine doses, our results show the largest increase between 4 weeks and >3 months after a second dose. We found changes in immunodominance of different spike regions, depending on the variant an individual was first exposed to, with implications for variant risk assessment and vaccine-strain selection.

Original language	English
Article number	eadj0070
Journal	Science
Volume	382
Issue number	6666
DOIs	https://doi.org/10.1126/science.adj0070
Publication status	Published - 6 Oct 2023

Bibliographical note

Publisher Copyright:
© 2023 American Association for the Advancement of Science. All rights reserved.

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Wilks, S. H., Mühlemann, B., Shen, X., Türeli, S., LeGresley, E. B., Netzl, A., Caniza, M. A., Chacaltana-Huarcaya, J. N., Corman, V. M., Daniell, X., Datto, M. B., Dawood, F. S., Denny, T. N., Drosten, C., Fouchier, R. A. M., Garcia, P. J., Halfmann, P. J., Jassem, A., Jeworowski, L. M., ... Smith, D. J. (2023). Mapping SARS-CoV-2 antigenic relationships and serological responses. Science, 382(6666), Article eadj0070. https://doi.org/10.1126/science.adj0070

@article{ff73660b48c5446c8ac7208efd3c4635,

title = "Mapping SARS-CoV-2 antigenic relationships and serological responses",

abstract = "During the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, multiple variants escaping preexisting immunity emerged, causing reinfections of previously exposed individuals. Here, we used antigenic cartography to analyze patterns of cross-reactivity among 21 variants and 15 groups of human sera obtained after primary infection with 10 different variants or after messenger RNA (mRNA)–1273 or mRNA-1273.351 vaccination. We found antigenic differences among pre-Omicron variants caused by substitutions at spike-protein positions 417, 452, 484, and 501. Quantifying changes in response breadth over time and with additional vaccine doses, our results show the largest increase between 4 weeks and >3 months after a second dose. We found changes in immunodominance of different spike regions, depending on the variant an individual was first exposed to, with implications for variant risk assessment and vaccine-strain selection.",

author = "Wilks, \{Samuel H.\} and Barbara M{\"u}hlemann and Xiaoying Shen and Sina T{\"u}reli and LeGresley, \{Eric B.\} and Antonia Netzl and Caniza, \{Miguela A.\} and Chacaltana-Huarcaya, \{Jesus N.\} and Corman, \{Victor M.\} and Xiaoju Daniell and Datto, \{Michael B.\} and Dawood, \{Fatimah S.\} and Denny, \{Thomas N.\} and Christian Drosten and Fouchier, \{Ron A.M.\} and Garcia, \{Patricia J.\} and Halfmann, \{Peter J.\} and Agatha Jassem and Jeworowski, \{Lara M.\} and Jones, \{Terry C.\} and Yoshihiro Kawaoka and Florian Krammer and Charlene McDanal and Rolando Pajon and Viviana Simon and Stockwell, \{Melissa S.\} and Haili Tang and \{van Bakel\}, Harm and Vic Veguilla and Richard Webby and Montefiori, \{David C.\} and Smith, \{Derek J.\}",

year = "2023",

month = oct,

day = "6",

doi = "10.1126/science.adj0070",

language = "English",

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Wilks, SH, Mühlemann, B, Shen, X, Türeli, S, LeGresley, EB, Netzl, A, Caniza, MA, Chacaltana-Huarcaya, JN, Corman, VM, Daniell, X, Datto, MB, Dawood, FS, Denny, TN, Drosten, C, Fouchier, RAM, Garcia, PJ, Halfmann, PJ, Jassem, A, Jeworowski, LM, Jones, TC, Kawaoka, Y, Krammer, F, McDanal, C, Pajon, R, Simon, V, Stockwell, MS, Tang, H, van Bakel, H, Veguilla, V, Webby, R, Montefiori, DC & Smith, DJ 2023, 'Mapping SARS-CoV-2 antigenic relationships and serological responses', Science, vol. 382, no. 6666, eadj0070. https://doi.org/10.1126/science.adj0070

TY - JOUR

T1 - Mapping SARS-CoV-2 antigenic relationships and serological responses

AU - Wilks, Samuel H.

AU - Mühlemann, Barbara

AU - Shen, Xiaoying

AU - Türeli, Sina

AU - LeGresley, Eric B.

AU - Netzl, Antonia

AU - Caniza, Miguela A.

AU - Chacaltana-Huarcaya, Jesus N.

AU - Corman, Victor M.

AU - Daniell, Xiaoju

AU - Datto, Michael B.

AU - Dawood, Fatimah S.

AU - Denny, Thomas N.

AU - Drosten, Christian

AU - Fouchier, Ron A.M.

AU - Garcia, Patricia J.

AU - Halfmann, Peter J.

AU - Jassem, Agatha

AU - Jeworowski, Lara M.

AU - Jones, Terry C.

AU - Kawaoka, Yoshihiro

AU - Krammer, Florian

AU - McDanal, Charlene

AU - Pajon, Rolando

AU - Simon, Viviana

AU - Stockwell, Melissa S.

AU - Tang, Haili

AU - van Bakel, Harm

AU - Veguilla, Vic

AU - Webby, Richard

AU - Montefiori, David C.

AU - Smith, Derek J.

PY - 2023/10/6

Y1 - 2023/10/6

N2 - During the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, multiple variants escaping preexisting immunity emerged, causing reinfections of previously exposed individuals. Here, we used antigenic cartography to analyze patterns of cross-reactivity among 21 variants and 15 groups of human sera obtained after primary infection with 10 different variants or after messenger RNA (mRNA)–1273 or mRNA-1273.351 vaccination. We found antigenic differences among pre-Omicron variants caused by substitutions at spike-protein positions 417, 452, 484, and 501. Quantifying changes in response breadth over time and with additional vaccine doses, our results show the largest increase between 4 weeks and >3 months after a second dose. We found changes in immunodominance of different spike regions, depending on the variant an individual was first exposed to, with implications for variant risk assessment and vaccine-strain selection.

AB - During the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, multiple variants escaping preexisting immunity emerged, causing reinfections of previously exposed individuals. Here, we used antigenic cartography to analyze patterns of cross-reactivity among 21 variants and 15 groups of human sera obtained after primary infection with 10 different variants or after messenger RNA (mRNA)–1273 or mRNA-1273.351 vaccination. We found antigenic differences among pre-Omicron variants caused by substitutions at spike-protein positions 417, 452, 484, and 501. Quantifying changes in response breadth over time and with additional vaccine doses, our results show the largest increase between 4 weeks and >3 months after a second dose. We found changes in immunodominance of different spike regions, depending on the variant an individual was first exposed to, with implications for variant risk assessment and vaccine-strain selection.

UR - https://www.scopus.com/pages/publications/85175476447

U2 - 10.1126/science.adj0070

DO - 10.1126/science.adj0070

M3 - Article

C2 - 37797027

AN - SCOPUS:85175476447

SN - 0036-8075

VL - 382

JO - Science

JF - Science

IS - 6666

M1 - eadj0070

ER -

Mapping SARS-CoV-2 antigenic relationships and serological responses

Abstract

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