MARK-AGE biomarkers of ageing

A Burkle; M Moreno-Villanueva; J Bernhard; M Blasco; G Zondag; Jan Hoeijmakers; O Toussaint; B Grubeck-Loebenstein; E Mocchegiani; S Collino; ES Gonos; E Sikora; D Gradinaru; M Dolle; M Salmon; P Kristensen; HR Griffiths; C Libert; T Grune; N Breusing; A Simm; C Franceschi; M Capri; D Talbot; P Caiafa; B Friguet; PE (Eline) Slagboom; A Hervonen; M Hurme; R Aspinall

doi:10.1016/j.mad.2015.03.006

MARK-AGE biomarkers of ageing

A Burkle, M Moreno-Villanueva, J Bernhard, M Blasco, G Zondag, Jan Hoeijmakers, O Toussaint, B Grubeck-Loebenstein, E Mocchegiani, S Collino, ES Gonos, E Sikora, D Gradinaru, M Dolle, M Salmon, P Kristensen, HR Griffiths, C Libert, T Grune, N BreusingA Simm, C Franceschi, M Capri, D Talbot, P Caiafa, B Friguet, PE (Eline) Slagboom, A Hervonen, M Hurme, R Aspinall

Molecular Genetics

Research output: Contribution to journal › Article › Academic › peer-review

174 Citations (Scopus)

Abstract

Many candidate biomarkers of human ageing have been proposed in the scientific literature but in all cases their variability in cross-sectional studies is considerable, and therefore no single measurement has proven to serve a useful marker to determine, on its own, biological age. A plausible reason for this is the intrinsic multi-causal and multi-system nature of the ageing process. The recently completed MARK-AGE study was a large-scale integrated project supported by the European Commission. The major aim of this project was to conduct a population study comprising about 3200 subjects in order to identify a set of biomarkers of ageing which, as a combination of parameters with appropriate weighting, would measure biological age better than any marker in isolation. (C) 2015 The Authors. Published by Elsevier Ireland Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

Original language	Undefined/Unknown
Pages (from-to)	2-12
Number of pages	11
Journal	Mechanisms of Ageing and Development
Volume	151
DOIs	https://doi.org/10.1016/j.mad.2015.03.006
Publication status	Published - 2015

Research programs

EMC MGC-01-12-03

Access to Document

10.1016/j.mad.2015.03.006

http://hdl.handle.net/1765/81549

Cite this

Burkle, A., Moreno-Villanueva, M., Bernhard, J., Blasco, M., Zondag, G., Hoeijmakers, J., Toussaint, O., Grubeck-Loebenstein, B., Mocchegiani, E., Collino, S., Gonos, ES., Sikora, E., Gradinaru, D., Dolle, M., Salmon, M., Kristensen, P., Griffiths, HR., Libert, C., Grune, T., ... Aspinall, R. (2015). MARK-AGE biomarkers of ageing. Mechanisms of Ageing and Development, 151, 2-12. https://doi.org/10.1016/j.mad.2015.03.006

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title = "MARK-AGE biomarkers of ageing",

abstract = "Many candidate biomarkers of human ageing have been proposed in the scientific literature but in all cases their variability in cross-sectional studies is considerable, and therefore no single measurement has proven to serve a useful marker to determine, on its own, biological age. A plausible reason for this is the intrinsic multi-causal and multi-system nature of the ageing process. The recently completed MARK-AGE study was a large-scale integrated project supported by the European Commission. The major aim of this project was to conduct a population study comprising about 3200 subjects in order to identify a set of biomarkers of ageing which, as a combination of parameters with appropriate weighting, would measure biological age better than any marker in isolation. (C) 2015 The Authors. Published by Elsevier Ireland Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).",

author = "A Burkle and M Moreno-Villanueva and J Bernhard and M Blasco and G Zondag and Jan Hoeijmakers and O Toussaint and B Grubeck-Loebenstein and E Mocchegiani and S Collino and ES Gonos and E Sikora and D Gradinaru and M Dolle and M Salmon and P Kristensen and HR Griffiths and C Libert and T Grune and N Breusing and A Simm and C Franceschi and M Capri and D Talbot and P Caiafa and B Friguet and Slagboom, {PE (Eline)} and A Hervonen and M Hurme and R Aspinall",

year = "2015",

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Burkle, A, Moreno-Villanueva, M, Bernhard, J, Blasco, M, Zondag, G, Hoeijmakers, J, Toussaint, O, Grubeck-Loebenstein, B, Mocchegiani, E, Collino, S, Gonos, ES, Sikora, E, Gradinaru, D, Dolle, M, Salmon, M, Kristensen, P, Griffiths, HR, Libert, C, Grune, T, Breusing, N, Simm, A, Franceschi, C, Capri, M, Talbot, D, Caiafa, P, Friguet, B, Slagboom, PE, Hervonen, A, Hurme, M & Aspinall, R 2015, 'MARK-AGE biomarkers of ageing', Mechanisms of Ageing and Development, vol. 151, pp. 2-12. https://doi.org/10.1016/j.mad.2015.03.006

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T1 - MARK-AGE biomarkers of ageing

AU - Burkle, A

AU - Moreno-Villanueva, M

AU - Bernhard, J

AU - Blasco, M

AU - Zondag, G

AU - Hoeijmakers, Jan

AU - Toussaint, O

AU - Grubeck-Loebenstein, B

AU - Mocchegiani, E

AU - Collino, S

AU - Gonos, ES

AU - Sikora, E

AU - Gradinaru, D

AU - Dolle, M

AU - Salmon, M

AU - Kristensen, P

AU - Griffiths, HR

AU - Libert, C

AU - Grune, T

AU - Breusing, N

AU - Simm, A

AU - Franceschi, C

AU - Capri, M

AU - Talbot, D

AU - Caiafa, P

AU - Friguet, B

AU - Slagboom, PE (Eline)

AU - Hervonen, A

AU - Hurme, M

AU - Aspinall, R

PY - 2015

Y1 - 2015

N2 - Many candidate biomarkers of human ageing have been proposed in the scientific literature but in all cases their variability in cross-sectional studies is considerable, and therefore no single measurement has proven to serve a useful marker to determine, on its own, biological age. A plausible reason for this is the intrinsic multi-causal and multi-system nature of the ageing process. The recently completed MARK-AGE study was a large-scale integrated project supported by the European Commission. The major aim of this project was to conduct a population study comprising about 3200 subjects in order to identify a set of biomarkers of ageing which, as a combination of parameters with appropriate weighting, would measure biological age better than any marker in isolation. (C) 2015 The Authors. Published by Elsevier Ireland Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

AB - Many candidate biomarkers of human ageing have been proposed in the scientific literature but in all cases their variability in cross-sectional studies is considerable, and therefore no single measurement has proven to serve a useful marker to determine, on its own, biological age. A plausible reason for this is the intrinsic multi-causal and multi-system nature of the ageing process. The recently completed MARK-AGE study was a large-scale integrated project supported by the European Commission. The major aim of this project was to conduct a population study comprising about 3200 subjects in order to identify a set of biomarkers of ageing which, as a combination of parameters with appropriate weighting, would measure biological age better than any marker in isolation. (C) 2015 The Authors. Published by Elsevier Ireland Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

U2 - 10.1016/j.mad.2015.03.006

DO - 10.1016/j.mad.2015.03.006

M3 - Article

C2 - 25818235

SN - 0047-6374

VL - 151

SP - 2

EP - 12

JO - Mechanisms of Ageing and Development

JF - Mechanisms of Ageing and Development

ER -