Maternal bisphenol urine concentrations, fetal growth and adverse birth outcomes: A population-based prospective cohort

Chalana M. Sol; Charissa van Zwol - Janssens; Elise M. Philips; Alexandros G. Asimakopoulos; Maria Pilar Martinez-Moral; Kurunthachalam Kannan; Vincent W.V. Jaddoe; Leonardo Trasande; Susana Santos

doi:10.1186/s12940-021-00747-6

Maternal bisphenol urine concentrations, fetal growth and adverse birth outcomes: A population-based prospective cohort

Chalana M. Sol, Charissa van Zwol - Janssens, Elise M. Philips, Alexandros G. Asimakopoulos, Maria Pilar Martinez-Moral, Kurunthachalam Kannan, Vincent W.V. Jaddoe^*, Leonardo Trasande, Susana Santos

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

38 Citations (Scopus)

Abstract

Background: Exposure to bisphenols may affect fetal growth and development. The trimester-specific effects of bisphenols on repeated measures of fetal growth remain unknown. Our objective was to assess the associations of maternal bisphenol urine concentrations with fetal growth measures and birth outcomes and identify potential critical exposure periods. Methods: In a population-based prospective cohort study among 1379 pregnant women, we measured maternal bisphenol A, S and F urine concentrations in the first, second and third trimester. Fetal head circumference, length and weight were measured in the second and third trimester by ultrasound and at birth. Results: An interquartile range increase in maternal pregnancy-averaged bisphenol S concentrations was associated with larger fetal head circumference (difference 0.18 (95% confidence interval (CI) 0.01 to 0.34) standard deviation scores (SDS), p-value< 0.05) across pregnancy. When focusing on specific critical exposure periods, any detection of first trimester bisphenol S was associated with larger second and third trimester fetal head circumference (difference 0.15 (95% CI 0.05 to 0.26) and 0.12 (95% CI 0.02 to 0.23) SDS, respectively) and fetal weight (difference 0.12 (95% CI 0.02 to 0.22) and 0.16 (95% CI 0.06 to 0.26) SDS, respectively). The other bisphenols were not consistently associated with fetal growth outcomes. Any detection of bisphenol S and bisphenol F in first trimester was also associated with a lower risk of being born small size for gestational age (Odds Ratio 0.56 (95% CI 0.38 to 0.74) and 0.55 (95% CI 0.36 to 0.85), respectively). Bisphenols were not associated with risk of preterm birth. Conclusions: Higher maternal bisphenol S urine concentrations, especially in the first trimester, seem to be related with larger fetal head circumference, higher weight and a lower risk of being small size for gestational age at birth.

Original language	English
Article number	60
Journal	Environmental Health: A Global Access Science Source
Volume	20
Issue number	1
DOIs	https://doi.org/10.1186/s12940-021-00747-6
Publication status	Published - 15 May 2021

Bibliographical note

Funding Information:
The general design of the Generation R Study is made possible by financial support from the Erasmus MC, University Medical Center, Rotterdam, the Netherlands, the Organization for Health Research and Development (ZonMw) and the Ministry of Health, Welfare and Sport. This study was supported by grants RO1ES-022972 and RO1ES-029779 from the National Institutes of Health, USA. The content is solely the responsibility of the authors and does not represent the official views of the National Institutes of Health. This work was supported by the European Union’s Horizon 2020 research and innovation programme under grant agreement 874583 (ATHLETE Project). VWVJ received additional grant from the European Research Council (ERC Consolidator Grant, ERC-2014-CoG-64916).

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© 2021, The Author(s).

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Sol, C. M., van Zwol - Janssens, C., Philips, E. M., Asimakopoulos, A. G., Martinez-Moral, M. P., Kannan, K., Jaddoe, V. W. V., Trasande, L., & Santos, S. (2021). Maternal bisphenol urine concentrations, fetal growth and adverse birth outcomes: A population-based prospective cohort. Environmental Health: A Global Access Science Source, 20(1), Article 60. https://doi.org/10.1186/s12940-021-00747-6

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title = "Maternal bisphenol urine concentrations, fetal growth and adverse birth outcomes: A population-based prospective cohort",

abstract = "Background: Exposure to bisphenols may affect fetal growth and development. The trimester-specific effects of bisphenols on repeated measures of fetal growth remain unknown. Our objective was to assess the associations of maternal bisphenol urine concentrations with fetal growth measures and birth outcomes and identify potential critical exposure periods. Methods: In a population-based prospective cohort study among 1379 pregnant women, we measured maternal bisphenol A, S and F urine concentrations in the first, second and third trimester. Fetal head circumference, length and weight were measured in the second and third trimester by ultrasound and at birth. Results: An interquartile range increase in maternal pregnancy-averaged bisphenol S concentrations was associated with larger fetal head circumference (difference 0.18 (95% confidence interval (CI) 0.01 to 0.34) standard deviation scores (SDS), p-value< 0.05) across pregnancy. When focusing on specific critical exposure periods, any detection of first trimester bisphenol S was associated with larger second and third trimester fetal head circumference (difference 0.15 (95% CI 0.05 to 0.26) and 0.12 (95% CI 0.02 to 0.23) SDS, respectively) and fetal weight (difference 0.12 (95% CI 0.02 to 0.22) and 0.16 (95% CI 0.06 to 0.26) SDS, respectively). The other bisphenols were not consistently associated with fetal growth outcomes. Any detection of bisphenol S and bisphenol F in first trimester was also associated with a lower risk of being born small size for gestational age (Odds Ratio 0.56 (95% CI 0.38 to 0.74) and 0.55 (95% CI 0.36 to 0.85), respectively). Bisphenols were not associated with risk of preterm birth. Conclusions: Higher maternal bisphenol S urine concentrations, especially in the first trimester, seem to be related with larger fetal head circumference, higher weight and a lower risk of being small size for gestational age at birth.",

author = "Sol, {Chalana M.} and {van Zwol - Janssens}, Charissa and Philips, {Elise M.} and Asimakopoulos, {Alexandros G.} and Martinez-Moral, {Maria Pilar} and Kurunthachalam Kannan and Jaddoe, {Vincent W.V.} and Leonardo Trasande and Susana Santos",

note = "Funding Information: The general design of the Generation R Study is made possible by financial support from the Erasmus MC, University Medical Center, Rotterdam, the Netherlands, the Organization for Health Research and Development (ZonMw) and the Ministry of Health, Welfare and Sport. This study was supported by grants RO1ES-022972 and RO1ES-029779 from the National Institutes of Health, USA. The content is solely the responsibility of the authors and does not represent the official views of the National Institutes of Health. This work was supported by the European Union{\textquoteright}s Horizon 2020 research and innovation programme under grant agreement 874583 (ATHLETE Project). VWVJ received additional grant from the European Research Council (ERC Consolidator Grant, ERC-2014-CoG-64916). Publisher Copyright: {\textcopyright} 2021, The Author(s).",

year = "2021",

month = may,

day = "15",

doi = "10.1186/s12940-021-00747-6",

language = "English",

volume = "20",

journal = "Environmental Health: A Global Access Science Source",

issn = "1476-069X",

publisher = "BioMed Central Ltd.",

number = "1",

}

Sol, CM , van Zwol - Janssens, C, Philips, EM, Asimakopoulos, AG, Martinez-Moral, MP, Kannan, K, Jaddoe, VWV, Trasande, L & Santos, S 2021, 'Maternal bisphenol urine concentrations, fetal growth and adverse birth outcomes: A population-based prospective cohort', Environmental Health: A Global Access Science Source, vol. 20, no. 1, 60. https://doi.org/10.1186/s12940-021-00747-6

TY - JOUR

T1 - Maternal bisphenol urine concentrations, fetal growth and adverse birth outcomes

T2 - A population-based prospective cohort

AU - Sol, Chalana M.

AU - van Zwol - Janssens, Charissa

AU - Philips, Elise M.

AU - Asimakopoulos, Alexandros G.

AU - Martinez-Moral, Maria Pilar

AU - Kannan, Kurunthachalam

AU - Jaddoe, Vincent W.V.

AU - Trasande, Leonardo

AU - Santos, Susana

N1 - Funding Information: The general design of the Generation R Study is made possible by financial support from the Erasmus MC, University Medical Center, Rotterdam, the Netherlands, the Organization for Health Research and Development (ZonMw) and the Ministry of Health, Welfare and Sport. This study was supported by grants RO1ES-022972 and RO1ES-029779 from the National Institutes of Health, USA. The content is solely the responsibility of the authors and does not represent the official views of the National Institutes of Health. This work was supported by the European Union’s Horizon 2020 research and innovation programme under grant agreement 874583 (ATHLETE Project). VWVJ received additional grant from the European Research Council (ERC Consolidator Grant, ERC-2014-CoG-64916). Publisher Copyright: © 2021, The Author(s).

PY - 2021/5/15

Y1 - 2021/5/15

N2 - Background: Exposure to bisphenols may affect fetal growth and development. The trimester-specific effects of bisphenols on repeated measures of fetal growth remain unknown. Our objective was to assess the associations of maternal bisphenol urine concentrations with fetal growth measures and birth outcomes and identify potential critical exposure periods. Methods: In a population-based prospective cohort study among 1379 pregnant women, we measured maternal bisphenol A, S and F urine concentrations in the first, second and third trimester. Fetal head circumference, length and weight were measured in the second and third trimester by ultrasound and at birth. Results: An interquartile range increase in maternal pregnancy-averaged bisphenol S concentrations was associated with larger fetal head circumference (difference 0.18 (95% confidence interval (CI) 0.01 to 0.34) standard deviation scores (SDS), p-value< 0.05) across pregnancy. When focusing on specific critical exposure periods, any detection of first trimester bisphenol S was associated with larger second and third trimester fetal head circumference (difference 0.15 (95% CI 0.05 to 0.26) and 0.12 (95% CI 0.02 to 0.23) SDS, respectively) and fetal weight (difference 0.12 (95% CI 0.02 to 0.22) and 0.16 (95% CI 0.06 to 0.26) SDS, respectively). The other bisphenols were not consistently associated with fetal growth outcomes. Any detection of bisphenol S and bisphenol F in first trimester was also associated with a lower risk of being born small size for gestational age (Odds Ratio 0.56 (95% CI 0.38 to 0.74) and 0.55 (95% CI 0.36 to 0.85), respectively). Bisphenols were not associated with risk of preterm birth. Conclusions: Higher maternal bisphenol S urine concentrations, especially in the first trimester, seem to be related with larger fetal head circumference, higher weight and a lower risk of being small size for gestational age at birth.

AB - Background: Exposure to bisphenols may affect fetal growth and development. The trimester-specific effects of bisphenols on repeated measures of fetal growth remain unknown. Our objective was to assess the associations of maternal bisphenol urine concentrations with fetal growth measures and birth outcomes and identify potential critical exposure periods. Methods: In a population-based prospective cohort study among 1379 pregnant women, we measured maternal bisphenol A, S and F urine concentrations in the first, second and third trimester. Fetal head circumference, length and weight were measured in the second and third trimester by ultrasound and at birth. Results: An interquartile range increase in maternal pregnancy-averaged bisphenol S concentrations was associated with larger fetal head circumference (difference 0.18 (95% confidence interval (CI) 0.01 to 0.34) standard deviation scores (SDS), p-value< 0.05) across pregnancy. When focusing on specific critical exposure periods, any detection of first trimester bisphenol S was associated with larger second and third trimester fetal head circumference (difference 0.15 (95% CI 0.05 to 0.26) and 0.12 (95% CI 0.02 to 0.23) SDS, respectively) and fetal weight (difference 0.12 (95% CI 0.02 to 0.22) and 0.16 (95% CI 0.06 to 0.26) SDS, respectively). The other bisphenols were not consistently associated with fetal growth outcomes. Any detection of bisphenol S and bisphenol F in first trimester was also associated with a lower risk of being born small size for gestational age (Odds Ratio 0.56 (95% CI 0.38 to 0.74) and 0.55 (95% CI 0.36 to 0.85), respectively). Bisphenols were not associated with risk of preterm birth. Conclusions: Higher maternal bisphenol S urine concentrations, especially in the first trimester, seem to be related with larger fetal head circumference, higher weight and a lower risk of being small size for gestational age at birth.

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U2 - 10.1186/s12940-021-00747-6

DO - 10.1186/s12940-021-00747-6

M3 - Article

C2 - 33992119

AN - SCOPUS:85105966019

SN - 1476-069X

VL - 20

JO - Environmental Health: A Global Access Science Source

JF - Environmental Health: A Global Access Science Source

IS - 1

M1 - 60

ER -

Maternal bisphenol urine concentrations, fetal growth and adverse birth outcomes: A population-based prospective cohort

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