Maternal caffeine consumption during pregnancy and offspring cord blood DNA methylation: an epigenome-wide association study meta-analysis

Laura Schellhas; Giulietta S. Monasso; Janine F. Felix; Vincent Wv Jaddoe; Peiyuan Huang; Sílvia Fernández-Barrés; Martine Vrijheid; Giancarlo Pesce; Isabella Annesi-Maesano; Christian M. Page; Anne Lise Brantsæter; Mona Bekkhus; Siri E. Håberg; Stephanie J. London; Marcus R. Munafò; Luisa Zuccolo; Gemma C. Sharp

doi:10.2217/epi-2023-0263

Maternal caffeine consumption during pregnancy and offspring cord blood DNA methylation: an epigenome-wide association study meta-analysis

Laura Schellhas^*
, Giulietta S. Monasso
, Janine F. Felix
, Vincent Wv Jaddoe
, Peiyuan Huang
, Sílvia Fernández-Barrés
, Martine Vrijheid
, Giancarlo Pesce
, Isabella Annesi-Maesano
, Christian M. Page
, Anne Lise Brantsæter
, Mona Bekkhus
, Siri E. Håberg
, Stephanie J. London
, Marcus R. Munafò
, Luisa Zuccolo
, Gemma C. Sharp

^*Corresponding author for this work

Pediatrics

Research output: Contribution to journal › Review article › Academic › peer-review

2 Citations (Scopus)

41 Downloads (Pure)

Abstract

Background:
Prenatal caffeine exposure may influence offspring health via DNA methylation, but no large studies have tested this.

Materials & methods:
Epigenome-wide association studies and differentially methylated regions in cord blood (450k or EPIC Illumina arrays) were meta-analyzed across six European cohorts (n = 3725). Differential methylation related to self-reported caffeine intake (mg/day) from coffee, tea and cola was compared with assess whether caffeine is driving effects.

Results:
One CpG site (cg19370043, PRRX1) was associated with caffeine and another (cg14591243, STAG1) with cola intake. A total of 12-22 differentially methylated regions were detected with limited overlap across caffeinated beverages.

Conclusion:
We found little evidence to support an intrauterine effect of caffeine on offspring DNA methylation. Statistical power limitations may have impacted our findings.

Original language	English
Pages (from-to)	1179-1193
Number of pages	15
Journal	Epigenomics
Volume	15
Issue number	22
DOIs	https://doi.org/10.2217/epi-2023-0263
Publication status	Published - 1 Nov 2023

Bibliographical note

Publisher Copyright:
© 2023 The Authors.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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schellhas-et-al-2023-maternal-caffeine-consumption-during-pregnancy-and-offspring-cord-blood-dna-methylation-anFinal published version, 1.7 MBLicence: CC BY

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Schellhas, L., Monasso, G. S., Felix, J. F., Jaddoe, V. W., Huang, P., Fernández-Barrés, S., Vrijheid, M., Pesce, G., Annesi-Maesano, I., Page, C. M., Brantsæter, A. L., Bekkhus, M., Håberg, S. E., London, S. J., Munafò, M. R., Zuccolo, L., & Sharp, G. C. (2023). Maternal caffeine consumption during pregnancy and offspring cord blood DNA methylation: an epigenome-wide association study meta-analysis. Epigenomics, 15(22), 1179-1193. https://doi.org/10.2217/epi-2023-0263

@article{7d008a14675e41d8a454f435c804aa99,

title = "Maternal caffeine consumption during pregnancy and offspring cord blood DNA methylation: an epigenome-wide association study meta-analysis",

abstract = "Background: Prenatal caffeine exposure may influence offspring health via DNA methylation, but no large studies have tested this. Materials \& methods: Epigenome-wide association studies and differentially methylated regions in cord blood (450k or EPIC Illumina arrays) were meta-analyzed across six European cohorts (n = 3725). Differential methylation related to self-reported caffeine intake (mg/day) from coffee, tea and cola was compared with assess whether caffeine is driving effects. Results: One CpG site (cg19370043, PRRX1) was associated with caffeine and another (cg14591243, STAG1) with cola intake. A total of 12-22 differentially methylated regions were detected with limited overlap across caffeinated beverages. Conclusion: We found little evidence to support an intrauterine effect of caffeine on offspring DNA methylation. Statistical power limitations may have impacted our findings. ",

author = "Laura Schellhas and Monasso, \{Giulietta S.\} and Felix, \{Janine F.\} and Jaddoe, \{Vincent Wv\} and Peiyuan Huang and S{\'i}lvia Fern{\'a}ndez-Barr{\'e}s and Martine Vrijheid and Giancarlo Pesce and Isabella Annesi-Maesano and Page, \{Christian M.\} and Brants{\ae}ter, \{Anne Lise\} and Mona Bekkhus and H{\aa}berg, \{Siri E.\} and London, \{Stephanie J.\} and Munaf{\`o}, \{Marcus R.\} and Luisa Zuccolo and Sharp, \{Gemma C.\}",

note = "Publisher Copyright: {\textcopyright} 2023 The Authors.",

year = "2023",

month = nov,

day = "1",

doi = "10.2217/epi-2023-0263",

language = "English",

volume = "15",

pages = "1179--1193",

journal = "Epigenomics",

issn = "1750-1911",

publisher = "Taylor \& Francis Ltd (UK)",

number = "22",

}

Schellhas, L, Monasso, GS, Felix, JF , Jaddoe, VW, Huang, P, Fernández-Barrés, S, Vrijheid, M, Pesce, G, Annesi-Maesano, I, Page, CM, Brantsæter, AL, Bekkhus, M, Håberg, SE, London, SJ, Munafò, MR, Zuccolo, L & Sharp, GC 2023, 'Maternal caffeine consumption during pregnancy and offspring cord blood DNA methylation: an epigenome-wide association study meta-analysis', Epigenomics, vol. 15, no. 22, pp. 1179-1193. https://doi.org/10.2217/epi-2023-0263

TY - JOUR

T1 - Maternal caffeine consumption during pregnancy and offspring cord blood DNA methylation

T2 - an epigenome-wide association study meta-analysis

AU - Schellhas, Laura

AU - Monasso, Giulietta S.

AU - Felix, Janine F.

AU - Jaddoe, Vincent Wv

AU - Huang, Peiyuan

AU - Fernández-Barrés, Sílvia

AU - Vrijheid, Martine

AU - Pesce, Giancarlo

AU - Annesi-Maesano, Isabella

AU - Page, Christian M.

AU - Brantsæter, Anne Lise

AU - Bekkhus, Mona

AU - Håberg, Siri E.

AU - London, Stephanie J.

AU - Munafò, Marcus R.

AU - Zuccolo, Luisa

AU - Sharp, Gemma C.

PY - 2023/11/1

Y1 - 2023/11/1

N2 - Background: Prenatal caffeine exposure may influence offspring health via DNA methylation, but no large studies have tested this. Materials & methods: Epigenome-wide association studies and differentially methylated regions in cord blood (450k or EPIC Illumina arrays) were meta-analyzed across six European cohorts (n = 3725). Differential methylation related to self-reported caffeine intake (mg/day) from coffee, tea and cola was compared with assess whether caffeine is driving effects. Results: One CpG site (cg19370043, PRRX1) was associated with caffeine and another (cg14591243, STAG1) with cola intake. A total of 12-22 differentially methylated regions were detected with limited overlap across caffeinated beverages. Conclusion: We found little evidence to support an intrauterine effect of caffeine on offspring DNA methylation. Statistical power limitations may have impacted our findings.

AB - Background: Prenatal caffeine exposure may influence offspring health via DNA methylation, but no large studies have tested this. Materials & methods: Epigenome-wide association studies and differentially methylated regions in cord blood (450k or EPIC Illumina arrays) were meta-analyzed across six European cohorts (n = 3725). Differential methylation related to self-reported caffeine intake (mg/day) from coffee, tea and cola was compared with assess whether caffeine is driving effects. Results: One CpG site (cg19370043, PRRX1) was associated with caffeine and another (cg14591243, STAG1) with cola intake. A total of 12-22 differentially methylated regions were detected with limited overlap across caffeinated beverages. Conclusion: We found little evidence to support an intrauterine effect of caffeine on offspring DNA methylation. Statistical power limitations may have impacted our findings.

UR - https://www.scopus.com/pages/publications/85181263977

U2 - 10.2217/epi-2023-0263

DO - 10.2217/epi-2023-0263

M3 - Review article

C2 - 38018434

AN - SCOPUS:85181263977

SN - 1750-1911

VL - 15

SP - 1179

EP - 1193

JO - Epigenomics

JF - Epigenomics

IS - 22

ER -

Maternal caffeine consumption during pregnancy and offspring cord blood DNA methylation: an epigenome-wide association study meta-analysis

Abstract

Bibliographical note

UN SDGs

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