Maternal exposure to air pollution during pregnancy and child's cognitive, language, and motor function: ECLIPSES study

Lucía Iglesias-Vázquez; Anne Claire Binter; Josefa Canals; Carmen Hernández-Martínez; Núria Voltas; Albert Ambròs; Silvia Fernández-Barrés; Laura Pérez-Crespo; Mònica Guxens; Victoria Arija

doi:10.1016/j.envres.2022.113501

Maternal exposure to air pollution during pregnancy and child's cognitive, language, and motor function: ECLIPSES study

Lucía Iglesias-Vázquez
, Anne Claire Binter
, Josefa Canals
, Carmen Hernández-Martínez
, Núria Voltas
, Albert Ambròs
, Silvia Fernández-Barrés
, Laura Pérez-Crespo
, Mònica Guxens
, Victoria Arija^*

^*Corresponding author for this work

Child and Adolescent Psychiatry / Psychology

Universidad Rovira i Virgili
Hospital Universitari Sant Joan de Reus
Barcelona Institute for Global Health (ISGlobal)
Pompeu Fabra University
Instituto de Salud Carlos III
Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP)
Jordi Gol Primary Care Research Institute

Research output: Contribution to journal › Article › Academic › peer-review

26 Citations (Scopus)

102 Downloads (Pure)

Abstract

Prenatal exposure to air pollution, even at low levels, has been associated with negative effects on a child's neuropsychological functioning. The present work aimed to investigate the associations between prenatal exposure to air pollution on a child's cognitive, language, and motor function at 40 days of age in a highly exposed area of Spain. From the ECLIPSES study population, the present work counted 473 mother-child pairs. Traffic-related air pollution levels at home addresses during the whole pregnancy were estimated including particulate matter (PM) with an aerodynamic diameter <2.5 μm (PM_2.5), <10 μm (PM₁₀) and 2.5–10 μm (PM_coarse), PM_2.5absorbance, nitrogen dioxide (NO₂), other nitrogen oxides (NO_x), and ozone (O₃) using land-use regression models developed within ESCAPE and ELAPSE projects. Children's cognitive, language, and motor functions were assessed using the Bayley Scales of Infant Development 3rd edition (BSID-III) at around 40 days of age. Linear regression models were adjusted for maternal biological, sociodemographic and lifestyle characteristics, area deprivation index, and amount of greenness around the home's address. All air pollutants assessed, except PM_2.5 absorbance, were associated with lower motor function in children, while no association was observed between prenatal exposure to air pollution and cognitive and language functions. This finding highlights the need to continue raising awareness of the population-level impact that maternal exposure to air pollution even at low levels can have on the neuropsychological functions of children.

Original language	English
Article number	113501
Journal	Environmental Research
Volume	212
DOIs	https://doi.org/10.1016/j.envres.2022.113501
Publication status	Published - Sept 2022

Bibliographical note

Funding Information:
This work was financially supported by the Instituto de Salud Carlos III, Fondo de Investigación Sanitaria, Ministerio de Sanidad y Consumo [grant numbers PI12/02777 and PI17/01754 ] and co-funded by the European Union ( ERDF / ESF , “A way to make Europe”/“Investing in your future”). We thank the Jordi Gol University Institute for Primary Care Research [ Institut d’Investigació en Atenció Primària; IDIAP ] for their guidance regarding ethical matters. We acknowledge support from the Spanish Ministry of Science and Innovation and State Research Agency through the “ Centro de Excelencia Severo Ochoa 2019–2023 ” Program ( CEX 2018-000806-S ), and support from the Generalitat de Catalunya through the CERCA Program.

Funding Information:
This work was financially supported by the Instituto de Salud Carlos III , Fondo de Investigación Sanitaria, Ministerio de Sanidad y Consumo [grant numbers PI12/02777 , PI17/01754 , and CPII1800018 ] co-funded by the European Union ( ERDF / ESF , “A way to make Europe”/“Investing in your future”). We thank the Jordi Gol University Institute for Primary Care Research [ Institut d’Investigació en Atenció Primària; IDIAP ] for their guidance regarding ethical matters. We acknowledge support from the Spanish Ministry of Science and Innovation and State Research Agency through the “ Centro de Excelencia Severo Ochoa 2019–2023 ” Program ( CEX 2018-000806-S ), and support from the Generalitat de Catalunya through the CERCA Program.

Publisher Copyright:
© 2022 The Authors

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Cite this

Iglesias-Vázquez, L., Binter, A. C., Canals, J., Hernández-Martínez, C., Voltas, N., Ambròs, A., Fernández-Barrés, S., Pérez-Crespo, L., Guxens, M., & Arija, V. (2022). Maternal exposure to air pollution during pregnancy and child's cognitive, language, and motor function: ECLIPSES study. Environmental Research, 212, Article 113501. https://doi.org/10.1016/j.envres.2022.113501

@article{ef27f4c1c9c6436ea810aa209a26d024,

title = "Maternal exposure to air pollution during pregnancy and child's cognitive, language, and motor function: ECLIPSES study",

abstract = "Prenatal exposure to air pollution, even at low levels, has been associated with negative effects on a child's neuropsychological functioning. The present work aimed to investigate the associations between prenatal exposure to air pollution on a child's cognitive, language, and motor function at 40 days of age in a highly exposed area of Spain. From the ECLIPSES study population, the present work counted 473 mother-child pairs. Traffic-related air pollution levels at home addresses during the whole pregnancy were estimated including particulate matter (PM) with an aerodynamic diameter <2.5 μm (PM2.5), <10 μm (PM10) and 2.5–10 μm (PMcoarse), PM2.5absorbance, nitrogen dioxide (NO2), other nitrogen oxides (NOx), and ozone (O3) using land-use regression models developed within ESCAPE and ELAPSE projects. Children's cognitive, language, and motor functions were assessed using the Bayley Scales of Infant Development 3rd edition (BSID-III) at around 40 days of age. Linear regression models were adjusted for maternal biological, sociodemographic and lifestyle characteristics, area deprivation index, and amount of greenness around the home's address. All air pollutants assessed, except PM2.5 absorbance, were associated with lower motor function in children, while no association was observed between prenatal exposure to air pollution and cognitive and language functions. This finding highlights the need to continue raising awareness of the population-level impact that maternal exposure to air pollution even at low levels can have on the neuropsychological functions of children.",

author = "Luc{\'i}a Iglesias-V{\'a}zquez and Binter, \{Anne Claire\} and Josefa Canals and Carmen Hern{\'a}ndez-Mart{\'i}nez and N{\'u}ria Voltas and Albert Ambr{\`o}s and Silvia Fern{\'a}ndez-Barr{\'e}s and Laura P{\'e}rez-Crespo and M{\`o}nica Guxens and Victoria Arija",

note = "Funding Information: This work was financially supported by the Instituto de Salud Carlos III, Fondo de Investigaci{\'o}n Sanitaria, Ministerio de Sanidad y Consumo [grant numbers PI12/02777 and PI17/01754 ] and co-funded by the European Union ( ERDF / ESF , “A way to make Europe”/“Investing in your future”). We thank the Jordi Gol University Institute for Primary Care Research [ Institut d{\textquoteright}Investigaci{\'o} en Atenci{\'o} Prim{\`a}ria; IDIAP ] for their guidance regarding ethical matters. We acknowledge support from the Spanish Ministry of Science and Innovation and State Research Agency through the “ Centro de Excelencia Severo Ochoa 2019–2023 ” Program ( CEX 2018-000806-S ), and support from the Generalitat de Catalunya through the CERCA Program. Funding Information: This work was financially supported by the Instituto de Salud Carlos III , Fondo de Investigaci{\'o}n Sanitaria, Ministerio de Sanidad y Consumo [grant numbers PI12/02777 , PI17/01754 , and CPII1800018 ] co-funded by the European Union ( ERDF / ESF , “A way to make Europe”/“Investing in your future”). We thank the Jordi Gol University Institute for Primary Care Research [ Institut d{\textquoteright}Investigaci{\'o} en Atenci{\'o} Prim{\`a}ria; IDIAP ] for their guidance regarding ethical matters. We acknowledge support from the Spanish Ministry of Science and Innovation and State Research Agency through the “ Centro de Excelencia Severo Ochoa 2019–2023 ” Program ( CEX 2018-000806-S ), and support from the Generalitat de Catalunya through the CERCA Program. Publisher Copyright: {\textcopyright} 2022 The Authors",

year = "2022",

month = sep,

doi = "10.1016/j.envres.2022.113501",

language = "English",

volume = "212",

journal = "Environmental Research",

issn = "0013-9351",

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}

Iglesias-Vázquez, L, Binter, AC, Canals, J, Hernández-Martínez, C, Voltas, N, Ambròs, A, Fernández-Barrés, S, Pérez-Crespo, L, Guxens, M & Arija, V 2022, 'Maternal exposure to air pollution during pregnancy and child's cognitive, language, and motor function: ECLIPSES study', Environmental Research, vol. 212, 113501. https://doi.org/10.1016/j.envres.2022.113501

TY - JOUR

T1 - Maternal exposure to air pollution during pregnancy and child's cognitive, language, and motor function

T2 - ECLIPSES study

AU - Iglesias-Vázquez, Lucía

AU - Binter, Anne Claire

AU - Canals, Josefa

AU - Hernández-Martínez, Carmen

AU - Voltas, Núria

AU - Ambròs, Albert

AU - Fernández-Barrés, Silvia

AU - Pérez-Crespo, Laura

AU - Guxens, Mònica

AU - Arija, Victoria

N1 - Funding Information: This work was financially supported by the Instituto de Salud Carlos III, Fondo de Investigación Sanitaria, Ministerio de Sanidad y Consumo [grant numbers PI12/02777 and PI17/01754 ] and co-funded by the European Union ( ERDF / ESF , “A way to make Europe”/“Investing in your future”). We thank the Jordi Gol University Institute for Primary Care Research [ Institut d’Investigació en Atenció Primària; IDIAP ] for their guidance regarding ethical matters. We acknowledge support from the Spanish Ministry of Science and Innovation and State Research Agency through the “ Centro de Excelencia Severo Ochoa 2019–2023 ” Program ( CEX 2018-000806-S ), and support from the Generalitat de Catalunya through the CERCA Program. Funding Information: This work was financially supported by the Instituto de Salud Carlos III , Fondo de Investigación Sanitaria, Ministerio de Sanidad y Consumo [grant numbers PI12/02777 , PI17/01754 , and CPII1800018 ] co-funded by the European Union ( ERDF / ESF , “A way to make Europe”/“Investing in your future”). We thank the Jordi Gol University Institute for Primary Care Research [ Institut d’Investigació en Atenció Primària; IDIAP ] for their guidance regarding ethical matters. We acknowledge support from the Spanish Ministry of Science and Innovation and State Research Agency through the “ Centro de Excelencia Severo Ochoa 2019–2023 ” Program ( CEX 2018-000806-S ), and support from the Generalitat de Catalunya through the CERCA Program. Publisher Copyright: © 2022 The Authors

PY - 2022/9

Y1 - 2022/9

N2 - Prenatal exposure to air pollution, even at low levels, has been associated with negative effects on a child's neuropsychological functioning. The present work aimed to investigate the associations between prenatal exposure to air pollution on a child's cognitive, language, and motor function at 40 days of age in a highly exposed area of Spain. From the ECLIPSES study population, the present work counted 473 mother-child pairs. Traffic-related air pollution levels at home addresses during the whole pregnancy were estimated including particulate matter (PM) with an aerodynamic diameter <2.5 μm (PM2.5), <10 μm (PM10) and 2.5–10 μm (PMcoarse), PM2.5absorbance, nitrogen dioxide (NO2), other nitrogen oxides (NOx), and ozone (O3) using land-use regression models developed within ESCAPE and ELAPSE projects. Children's cognitive, language, and motor functions were assessed using the Bayley Scales of Infant Development 3rd edition (BSID-III) at around 40 days of age. Linear regression models were adjusted for maternal biological, sociodemographic and lifestyle characteristics, area deprivation index, and amount of greenness around the home's address. All air pollutants assessed, except PM2.5 absorbance, were associated with lower motor function in children, while no association was observed between prenatal exposure to air pollution and cognitive and language functions. This finding highlights the need to continue raising awareness of the population-level impact that maternal exposure to air pollution even at low levels can have on the neuropsychological functions of children.

AB - Prenatal exposure to air pollution, even at low levels, has been associated with negative effects on a child's neuropsychological functioning. The present work aimed to investigate the associations between prenatal exposure to air pollution on a child's cognitive, language, and motor function at 40 days of age in a highly exposed area of Spain. From the ECLIPSES study population, the present work counted 473 mother-child pairs. Traffic-related air pollution levels at home addresses during the whole pregnancy were estimated including particulate matter (PM) with an aerodynamic diameter <2.5 μm (PM2.5), <10 μm (PM10) and 2.5–10 μm (PMcoarse), PM2.5absorbance, nitrogen dioxide (NO2), other nitrogen oxides (NOx), and ozone (O3) using land-use regression models developed within ESCAPE and ELAPSE projects. Children's cognitive, language, and motor functions were assessed using the Bayley Scales of Infant Development 3rd edition (BSID-III) at around 40 days of age. Linear regression models were adjusted for maternal biological, sociodemographic and lifestyle characteristics, area deprivation index, and amount of greenness around the home's address. All air pollutants assessed, except PM2.5 absorbance, were associated with lower motor function in children, while no association was observed between prenatal exposure to air pollution and cognitive and language functions. This finding highlights the need to continue raising awareness of the population-level impact that maternal exposure to air pollution even at low levels can have on the neuropsychological functions of children.

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ER -

Maternal exposure to air pollution during pregnancy and child's cognitive, language, and motor function: ECLIPSES study

Abstract

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