Mechanisms and Consequences of Injury and Repair in Older Organ Transplants

BR Slegtenhorst, Frank Dor, A Elkhal, H Rodriguez, XY Yang, K Edtinger, M Quante, AS Chong, SG Tullius

Research output: Contribution to journalArticleAcademicpeer-review

37 Citations (Scopus)

Abstract

Donor organ scarcity remains a significant clinical challenge in transplantation. Older organs, increasingly utilized to meet the growing demand for donor organs, have been linked to inferior transplant outcomes. Susceptibility to organ injury, reduced repair capacity, and increased immunogenicity are interrelated and impacted by physiological and pathological aging processes. Insights into the underlying mechanisms are needed to develop age-specific interventional strategies with regards to organ preservation, immunosuppression, and allocation. In this overview, we summarize current knowledge of injury and repair mechanisms and the effects of aging relevant to transplantation.
Original languageUndefined/Unknown
Pages (from-to)1091-1099
Number of pages9
JournalTransplantation
Volume97
Issue number11
DOIs
Publication statusPublished - 2014

Research programs

  • EMC MM-04-47-07

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