Mechanisms of drug loading and release kinetics.

D. M. Whelan*, H. M. van Beusekom, W. J. van der Giessen

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

21 Citations (Scopus)


In an effort to overcome the limitations of local drug delivery associated with the use of catheters, drug-loaded stents have been developed. Loading of such stents is achieved through either drug absorption (incorporation into a matrix) or drug adsorption (surface layering). The type of drug binding determines the elution profile/release kinetics of the drug, while the therapeutic target determines both the choice of drug used and the manner in which it is bound, i.e. eluting or non-eluting. While non-eluting stents have clinically reduced thrombotic complications following stent implantation, current experimental work concentrates on the use of eluting stents to combat restenosis.

Original languageEnglish
Pages (from-to)127-131
Number of pages5
JournalSeminars in interventional cardiology : SIIC
Issue number3-4
Publication statusPublished - 1998


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