Mechanosensing and Mechanotransduction in Pulmonary Hypertension

Siyu Tian; Jarno J. Steenhorst; Kim van der Heiden; Daphne Merkus

doi:10.1007/978-3-030-63164-2_11

Mechanosensing and Mechanotransduction in Pulmonary Hypertension

Siyu Tian
, Jarno J. Steenhorst
, Kim van der Heiden
, Daphne Merkus^*

^*Corresponding author for this work

Cardiology

Walter-Brendel Center
German Center for Cardiovascular Research (DZHK)
Munich Heart Alliance (MHA)

Research output: Chapter/Conference proceeding › Chapter › Academic

1 Citation (Scopus)

Abstract

Pulmonary hypertension (PH) is a devastating disease with a poor outcome. Progressive remodeling of the pulmonary microvasculature leads to an increase in pulmonary vascular stiffness as well as to an increase in pulmonary vascular resistance. These alterations in mechanical characteristics of the pulmonary vasculature further contribute to the progression of pulmonary vascular disease. This chapter will focus on how changes in vascular stiffness affect mechanical forces acting on the endothelium and smooth muscle cells and how these changes in mechanical forces in turn contribute to the development and progression of pulmonary vascular disease with a focus on the role of mechanosensing and mechanotransduction in these processes.

Original language	English
Title of host publication	Cardiac and Vascular Biology
Publisher	Springer Science+Business Media
Pages	299–318
Number of pages	20
Volume	8
DOIs	https://doi.org/10.1007/978-3-030-63164-2_11
Publication status	Published - 2021

Publication series

Series	Cardiac and Vascular Biology
Volume	8
ISSN	2509-7830

Bibliographical note

Funding Information:
Compliance with Ethical Standards Conflict of Interest Authors declare that they have no conflict of interest. Ethical Approval This article does not contain any studies with human participants or animals performed by any of the authors. Sources of Funding Support of an Erasmus MC grant (DM), a DZHK grant (81Z0600207 to DM), and a grant from the Chinese Scholarship Council (CSC 201708130077 to ST) is gratefully acknowledged.

Publisher Copyright:
© 2021, Springer Nature Switzerland AG.

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10.1007/978-3-030-63164-2_11

Cite this

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abstract = "Pulmonary hypertension (PH) is a devastating disease with a poor outcome. Progressive remodeling of the pulmonary microvasculature leads to an increase in pulmonary vascular stiffness as well as to an increase in pulmonary vascular resistance. These alterations in mechanical characteristics of the pulmonary vasculature further contribute to the progression of pulmonary vascular disease. This chapter will focus on how changes in vascular stiffness affect mechanical forces acting on the endothelium and smooth muscle cells and how these changes in mechanical forces in turn contribute to the development and progression of pulmonary vascular disease with a focus on the role of mechanosensing and mechanotransduction in these processes.",

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N1 - Funding Information: Compliance with Ethical Standards Conflict of Interest Authors declare that they have no conflict of interest. Ethical Approval This article does not contain any studies with human participants or animals performed by any of the authors. Sources of Funding Support of an Erasmus MC grant (DM), a DZHK grant (81Z0600207 to DM), and a grant from the Chinese Scholarship Council (CSC 201708130077 to ST) is gratefully acknowledged. Publisher Copyright: © 2021, Springer Nature Switzerland AG.

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Mechanosensing and Mechanotransduction in Pulmonary Hypertension

Abstract

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