Medicatieaanpassingen bij 1 op de 3 patienten naar aanleiding van f armacogenetische bepalingen aangevraagd door Service Apotheken op basis van opgestelde inclusieprotocollen: SA-PGx pilot

Translated title of the contribution: Medication adjustments in 1 out 3 patients as a result of pharmacogenetic testing initiated by primary care pharmacists based on specific inclusion protocols (SA-PGx pilot)

M. Matic, W. Denneboom, W. Groenendijk, R. H.N. Van Schaik

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Medication adjustments in 7 out of 3 patients as a result of pharmacogenetic testing initiated by primary care pharmacists based on specific inclusion protocols (SA-PGx pilot) Background Pharmacogenetic analysis is currently performed at 16 certified laboratories in the Netherlands. For 90 different drugs pharmacogenetic advice is available, of which 23 drugs are frequently prescribed in primary care. Despite these opportunities the use of pharmacogenetic testing in primary care is still limited. Objective Investigate to what extent pharmacogenetic inclusion protocols and expert opinion of a pharmacist will lead to medication adjustments in patients. Design Prospective feasibility cohort study. Methods Eligible patients for pharmacogenetic testing are selected based on predefined inclusion protocols or pharmacist's expert opinion. DNA analysis is performed on buccal swab material collected in the pharmacy. Questionnaires, regarding drug-related complaints and patient satisfaction concerning provided care in the pharmacy, are filled in by the patients at baseline and after 1-2 weeks (no medication adjustments) or after 6 weeks (medication adjustments). Following study completion the application of pharmacogenetic testing is evaluated by the participating pharmacists. Results Over a period of 2 years 86 patients were included within 10 primary care pharmacies. Medication changes based on pharmacogenetic results were registered in 25 patients (29%). Almost 1/3 of these patients were selected based on the inclusion protocols. The most frequently changed drugs were clopidogrel, statins, pantoprazole and metoprolol. Drug complaints were reduced in 19% (n = 3) of the patients (not significant). The lack of imbursement in case of pharmacogenetic test requests from pharmacists was the most frequently mentioned barrier towards broad implementation of pharmacogenetics in primary care pharmacy. Conclusion Pharmacogenetic requests initiated by the pharmacist lead to medication adjustments in 30% of the patients with potentially also improvement in the pharmaco-therapy. Barriers such as imbursement require attention in order for pharmacogenetics to be applied more broadly in the primary care pharmacy.

Translated title of the contributionMedication adjustments in 1 out 3 patients as a result of pharmacogenetic testing initiated by primary care pharmacists based on specific inclusion protocols (SA-PGx pilot)
Original languageDutch
Pages (from-to)27-35
Number of pages9
JournalPharmaceutisch Weekblad
Volume158
Issue number44
Publication statusPublished - 3 Nov 2023

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© 2023 Kon. Ned. Mij. ter Bevordering der Pharmacie (KNMP). All rights reserved.

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