Mega-analysis methods in ENIGMA: The experience of the generalized anxiety disorder working group

André Zugman, Anita Harrewijn, Elise M Cardinale, Hannah Zwiebel, Gabrielle F Freitag, Katy E Werwath, Janna M Bas-Hoogendam, Nynke A Groenewold, Moji Aghajani, Kevin Hilbert, Narcis Cardoner, Daniel Porta-Casteràs, Savannah Gosnell, Ramiro Salas, Karina S Blair, James R Blair, Mira Z Hammoud, Mohammed Milad, Katie Burkhouse, K Luan PhanHeidi K Schroeder, Jeffrey R Strawn, Katja Beesdo-Baum, Sophia I Thomopoulos, Hans J Grabe, Sandra Van der Auwera, Katharina Wittfeld, Jared A Nielsen, Randy Buckner, Jordan W Smoller, Benson Mwangi, Jair C Soares, Mon-Ju Wu, Giovana B Zunta-Soares, Andrea P Jackowski, Pedro M Pan, Giovanni A Salum, Michal Assaf, Gretchen J Diefenbach, Paolo Brambilla, Eleonora Maggioni, David Hofmann, Thomas Straube, Carmen Andreescu, Rachel Berta, Erica Tamburo, Rebecca Price, Gisele G Manfro, Hugo D Critchley, Elena Makovac

Research output: Contribution to journalReview articleAcademicpeer-review

39 Citations (Scopus)


The ENIGMA group on Generalized Anxiety Disorder (ENIGMA-Anxiety/GAD) is part of a broader effort to investigate anxiety disorders using imaging and genetic data across multiple sites worldwide. The group is actively conducting a mega-analysis of a large number of brain structural scans. In this process, the group was confronted with many methodological challenges related to study planning and implementation, between-country transfer of subject-level data, quality control of a considerable amount of imaging data, and choices related to statistical methods and efficient use of resources. This report summarizes the background information and rationale for the various methodological decisions, as well as the approach taken to implement them. The goal is to document the approach and help guide other research groups working with large brain imaging data sets as they develop their own analytic pipelines for mega-analyses.

Original languageEnglish
JournalHuman Brain Mapping
Publication statusAccepted/In press - 29 Jun 2020
Externally publishedYes

Bibliographical note

© 2020 The Authors. Human Brain Mapping published by Wiley Periodicals LLC.


Dive into the research topics of 'Mega-analysis methods in ENIGMA: The experience of the generalized anxiety disorder working group'. Together they form a unique fingerprint.

Cite this