Melanin-concentrating hormone and its receptor are expressed and functional in human skin

Martin J. Hoogduijn; Janis Ancans; Itaru Suzuki; Siân Estdale; Anthony J. Thody

doi:10.1016/S0006-291X(02)00932-4

Melanin-concentrating hormone and its receptor are expressed and functional in human skin

Martin J. Hoogduijn^*, Janis Ancans, Itaru Suzuki, Siân Estdale, Anthony J. Thody

^*Corresponding author for this work

Internal Medicine

Research output: Contribution to journal › Article › Academic › peer-review

46 Citations (Scopus)

Abstract

In this study, we have demonstrated the presence of melanin-concentrating hormone (MCH) and melanin-concentrating hormone receptor (MCHR1) transcripts in human skin. Sequence analysis confirmed that the transcripts of both genes were identical to those previously found in human brain. In culture, endothelial cells showed pro-MCH expression whereas no signal was found in keratinocytes, melanocytes, and fibroblasts. MCHR1 expression was restricted to melanocytes and melanoma cells. Stimulation of cultured human melanocytes with MCH reduced the α-MSH-induced increase in cAMP production. Furthermore, the melanogenic actions of α-MSH were inhibited by MCH. We propose that the MCH/MCHR1 signalling system is present in human skin and may have a role with the melanocortins in regulating the melanocyte.

Original language	English
Pages (from-to)	698-701
Number of pages	4
Journal	Biochemical and Biophysical Research Communications
Volume	296
Issue number	3
DOIs	https://doi.org/10.1016/S0006-291X(02)00932-4
Publication status	Published - 2002

Access to Document

10.1016/S0006-291X(02)00932-4

Cite this

@article{d9b55bffb8ef4e5e89a3628bb2c22279,

title = "Melanin-concentrating hormone and its receptor are expressed and functional in human skin",

abstract = "In this study, we have demonstrated the presence of melanin-concentrating hormone (MCH) and melanin-concentrating hormone receptor (MCHR1) transcripts in human skin. Sequence analysis confirmed that the transcripts of both genes were identical to those previously found in human brain. In culture, endothelial cells showed pro-MCH expression whereas no signal was found in keratinocytes, melanocytes, and fibroblasts. MCHR1 expression was restricted to melanocytes and melanoma cells. Stimulation of cultured human melanocytes with MCH reduced the α-MSH-induced increase in cAMP production. Furthermore, the melanogenic actions of α-MSH were inhibited by MCH. We propose that the MCH/MCHR1 signalling system is present in human skin and may have a role with the melanocortins in regulating the melanocyte.",

author = "Hoogduijn, {Martin J.} and Janis Ancans and Itaru Suzuki and Si{\^a}n Estdale and Thody, {Anthony J.}",

year = "2002",

doi = "10.1016/S0006-291X(02)00932-4",

language = "English",

volume = "296",

pages = "698--701",

journal = "Biochemical and Biophysical Research Communications",

issn = "0006-291X",

publisher = "Elsevier",

number = "3",

}

TY - JOUR

T1 - Melanin-concentrating hormone and its receptor are expressed and functional in human skin

AU - Hoogduijn, Martin J.

AU - Ancans, Janis

AU - Suzuki, Itaru

AU - Estdale, Siân

AU - Thody, Anthony J.

PY - 2002

Y1 - 2002

N2 - In this study, we have demonstrated the presence of melanin-concentrating hormone (MCH) and melanin-concentrating hormone receptor (MCHR1) transcripts in human skin. Sequence analysis confirmed that the transcripts of both genes were identical to those previously found in human brain. In culture, endothelial cells showed pro-MCH expression whereas no signal was found in keratinocytes, melanocytes, and fibroblasts. MCHR1 expression was restricted to melanocytes and melanoma cells. Stimulation of cultured human melanocytes with MCH reduced the α-MSH-induced increase in cAMP production. Furthermore, the melanogenic actions of α-MSH were inhibited by MCH. We propose that the MCH/MCHR1 signalling system is present in human skin and may have a role with the melanocortins in regulating the melanocyte.

AB - In this study, we have demonstrated the presence of melanin-concentrating hormone (MCH) and melanin-concentrating hormone receptor (MCHR1) transcripts in human skin. Sequence analysis confirmed that the transcripts of both genes were identical to those previously found in human brain. In culture, endothelial cells showed pro-MCH expression whereas no signal was found in keratinocytes, melanocytes, and fibroblasts. MCHR1 expression was restricted to melanocytes and melanoma cells. Stimulation of cultured human melanocytes with MCH reduced the α-MSH-induced increase in cAMP production. Furthermore, the melanogenic actions of α-MSH were inhibited by MCH. We propose that the MCH/MCHR1 signalling system is present in human skin and may have a role with the melanocortins in regulating the melanocyte.

UR - http://www.scopus.com/inward/record.url?scp=0036382845&partnerID=8YFLogxK

U2 - 10.1016/S0006-291X(02)00932-4

DO - 10.1016/S0006-291X(02)00932-4

M3 - Article

C2 - 12176038

AN - SCOPUS:0036382845

SN - 0006-291X

VL - 296

SP - 698

EP - 701

JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

IS - 3

ER -

Melanin-concentrating hormone and its receptor are expressed and functional in human skin

Abstract

Access to Document

Other files and links

Fingerprint

Cite this