Melanin production in coelomycetous agents of black grain eumycetoma

Wilson Lim, Florianne Parel, Sybren de Hoog, Annelies Verbon, Wendy W.J. van de Sande

Research output: Contribution to journalArticleAcademicpeer-review

3 Citations (Scopus)
17 Downloads (Pure)


BACKGROUND: Eumycetoma is a fungal infection characterised by the formation of black grains by causative agents. The melanin biosynthetic pathways used by the most common causative agents of black-grain mycetoma are unknown and unravelling them could identify potential new therapeutic targets. METHOD: Melanin biosynthetic pathways in the causative fungi were identified by the use of specific melanin inhibitors. RESULTS: In Trematosphaeria grisea and Falciformispora tompkinsii, 1,8-dihydroxynaphthalene (DHN)-melanin synthesis was inhibited, while DHN-, 3,4-dihydroxyphenylalanine (DOPA)- and pyo-melanin were inhibited in Medicopsis romeroi and Falciformispora senegalensis. CONCLUSION: Our data suggest that Me. romeroi and F. senegalensis synthesise DHN-, DOPA- and pyo-melanin, while T. grisea and F. tompkinsii only synthesise DHN-melanin.

Original languageEnglish
Pages (from-to)324-327
Number of pages4
JournalTransactions of the Royal Society of Tropical Medicine and Hygiene
Issue number4
Early online date19 Jan 2021
Publication statusPublished - 14 Apr 2021

Bibliographical note

Publisher Copyright:
© The Author(s) 2021. Published by Oxford University Press on behalf of Royal Society of Tropical Medicine and Hygiene.


Dive into the research topics of 'Melanin production in coelomycetous agents of black grain eumycetoma'. Together they form a unique fingerprint.

Cite this