Melanin production in coelomycetous agents of black grain eumycetoma

Wilson Lim, Florianne Parel, Sybren de Hoog, Annelies Verbon, Wendy W.J. van de Sande

Research output: Contribution to journalArticleAcademicpeer-review

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Abstract

BACKGROUND: Eumycetoma is a fungal infection characterised by the formation of black grains by causative agents. The melanin biosynthetic pathways used by the most common causative agents of black-grain mycetoma are unknown and unravelling them could identify potential new therapeutic targets. METHOD: Melanin biosynthetic pathways in the causative fungi were identified by the use of specific melanin inhibitors. RESULTS: In Trematosphaeria grisea and Falciformispora tompkinsii, 1,8-dihydroxynaphthalene (DHN)-melanin synthesis was inhibited, while DHN-, 3,4-dihydroxyphenylalanine (DOPA)- and pyo-melanin were inhibited in Medicopsis romeroi and Falciformispora senegalensis. CONCLUSION: Our data suggest that Me. romeroi and F. senegalensis synthesise DHN-, DOPA- and pyo-melanin, while T. grisea and F. tompkinsii only synthesise DHN-melanin.

Original languageEnglish
Pages (from-to)324-327
Number of pages4
JournalTransactions of the Royal Society of Tropical Medicine and Hygiene
Volume115
Issue number4
Early online date19 Jan 2021
DOIs
Publication statusPublished - 14 Apr 2021

Bibliographical note

Publisher Copyright:
© The Author(s) 2021. Published by Oxford University Press on behalf of Royal Society of Tropical Medicine and Hygiene.

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