TY - JOUR
T1 - Mental health and its consequences in people living with HIV
T2 - A network approach
AU - Meeder, Elise M.G.
AU - Eekeren, Louise E.van
AU - Blaauw, Marc J.T.
AU - Groenendijk, Albert L.
AU - Vos, Wilhelm A.J.W.
AU - Lunzen, Jan van
AU - Joosten, Leo A.B.
AU - Netea, Mihai G.
AU - Mast, Quirijn de
AU - Blok, Willem L.
AU - Verbon, Annelies
AU - Berrevoets, Marvin A.H.
AU - Matzaraki, Vasiliki
AU - Ven, Andre J.A.M.van der
AU - Schellekens, Arnt F.A.
N1 - Publisher Copyright:
© 2024 The Author(s). Brain and Behavior published by Wiley Periodicals LLC.
PY - 2024/10
Y1 - 2024/10
N2 - Objectives: Psychiatric symptoms occur frequently in people living with human immunodeficiency virus (PLWH), which may affect quality of life, sexual risk behavior, and adherence to antiretroviral therapy (ART). Data from large cohorts are limited, and symptoms are often analyzed in isolation. Therefore, we applied a network analysis to assess the interrelatedness of mental health indicators in a large cohort of PLWH. Methods: We included 1615 PLWH on ART. Participants reported on the severity of depression, anxiety, impulsivity, substance use, quality of life, sexual risk behavior, and ART adherence. An Ising network model was constructed to analyze interrelations between mental health indicators and connections with clinical consequences. Results: Our network analysis revealed that symptoms of depression, anxiety, and indicators of impulsivity were interrelated. Substance use was prevalent and strongly connected with sexual risk behavior. Quality of life was most strongly connected with symptoms of depression. Unexpectedly, ART adherence did not display connections with any of the mental health indicators. Conclusion: In PLWH, the interrelatedness between symptoms of depression and anxiety and indicators of impulsivity is high. Mainly, depressive symptoms seem to impact quality of life, which warrants attention for depression in PLWH. We did not observe evidence for the common assumption that patients suffering from psychiatric symptoms are less adherent to HIV treatment.
AB - Objectives: Psychiatric symptoms occur frequently in people living with human immunodeficiency virus (PLWH), which may affect quality of life, sexual risk behavior, and adherence to antiretroviral therapy (ART). Data from large cohorts are limited, and symptoms are often analyzed in isolation. Therefore, we applied a network analysis to assess the interrelatedness of mental health indicators in a large cohort of PLWH. Methods: We included 1615 PLWH on ART. Participants reported on the severity of depression, anxiety, impulsivity, substance use, quality of life, sexual risk behavior, and ART adherence. An Ising network model was constructed to analyze interrelations between mental health indicators and connections with clinical consequences. Results: Our network analysis revealed that symptoms of depression, anxiety, and indicators of impulsivity were interrelated. Substance use was prevalent and strongly connected with sexual risk behavior. Quality of life was most strongly connected with symptoms of depression. Unexpectedly, ART adherence did not display connections with any of the mental health indicators. Conclusion: In PLWH, the interrelatedness between symptoms of depression and anxiety and indicators of impulsivity is high. Mainly, depressive symptoms seem to impact quality of life, which warrants attention for depression in PLWH. We did not observe evidence for the common assumption that patients suffering from psychiatric symptoms are less adherent to HIV treatment.
UR - https://www.scopus.com/pages/publications/85206871901
U2 - 10.1002/brb3.70021
DO - 10.1002/brb3.70021
M3 - Article
C2 - 39428553
AN - SCOPUS:85206871901
SN - 2157-9032
VL - 14
JO - Brain and Behavior
JF - Brain and Behavior
IS - 10
M1 - e70021
ER -
