Mental health in people with Parkinson’s disease during the COVID-19 pandemic: potential for targeted interventions?

L. J. Dommershuijsen; A. Van der Heide; E. M. Van den Berg; J. A. Labrecque; M. K. Ikram; M. A. Ikram; B. R. Bloem; R. C. Helmich; S. K.L. Darweesh

doi:10.1038/s41531-021-00238-y

Mental health in people with Parkinson’s disease during the COVID-19 pandemic: potential for targeted interventions?

L. J. Dommershuijsen, A. Van der Heide, E. M. Van den Berg, J. A. Labrecque, M. K. Ikram, M. A. Ikram, B. R. Bloem, R. C. Helmich, S. K.L. Darweesh^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

13 Citations (Scopus)

19 Downloads (Pure)

Abstract

The COVID-19 pandemic has introduced a myriad of challenges to the social life and care of people with Parkinson’s disease (PD), which could potentially worsen mental health problems. We used baseline data of the PRIME-NL study (N = 844) to examine whether the association between COVID-19 stressors and mental health is disproportionately large in specific subgroups of people with PD and to explore effects of hypothetical reductions in COVID-19 stressors on mental health and quality of life. The mean (SD) age of the study population was 70.3 (7.8) years and 321 (38.0%) were women. The linear regression effect estimate of the association of COVID-19 stressors with mental health was most pronounced in women, highly educated people, people with advanced PD and people prone to distancing or seeking social support. Smaller effect estimates were found in people scoring high on confrontive coping or planful problem solving. The parametric G-formula method was used to calculate the effects of hypothetical interventions on COVID-19 stressors. An intervention reducing stressors with 50% in people with above median MDS-UPDRS-II decreased the Beck Depression Inventory in this group from 14.7 to 10.6, the State-Trait Anxiety Inventory from 81.6 to 73.1 and the Parkinson’s Disease Quality of Life Questionnaire from 35.0 to 24.3. Insights from this cross-sectional study help to inform tailored care interventions to subgroups of people with PD most vulnerable to the impact of COVID-19 on mental health and quality of life.

Original language	English
Article number	95
Journal	npj Parkinson's Disease
Volume	7
Issue number	1
Early online date	28 Oct 2021
DOIs	https://doi.org/10.1038/s41531-021-00238-y
Publication status	Published - Dec 2021

Bibliographical note

Funding Information:
This research is part of the collaborative Proactive and Integrated Management and Empowerment in Parkinson’s Disease (PRIME Parkinson) project, which is a healthcare innovation project in selected areas of the United Kingdom and the Netherlands. The PRIME Parkinson project is financed by the Gatsby Foundation and co-funded by the PPP Allowance made available by Health~Holland, Top Sector Life Sciences & Health, to stimulate public-private partnerships. S.K.L.D. was supported in part by a Parkinson’s Foundation–Postdoctoral Fellowship (PF-FBS-2026). M.K.I., M.A.I., and L. J.D. were supported in part by a Stichting Parkinson Fonds grant. B.R.B. currently serves as co-Editor in Chief for the Journal of Parkinson’s disease, serves on the editorial of Practical Neurology and Digital Biomarkers, has received honoraria from serving on the scientific advisory board for Abbvie, Biogen and UCB, has received fees for speaking at conferences from AbbVie, Zambon, Roche, GE Healthcare and Bial, and has received research support from the Netherlands Organization for Scientific Research, the Michael J Fox Foundation, UCB, Abbvie, the Stichting Parkinson Fonds, the Hersenstichting Nederland, the Parkinson’s Foundation, Verily Life Sciences, Horizon 2020 and the Parkinson Vereniging.

Publisher Copyright:
© 2021, The Author(s).

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1038/s41531-021-00238-yLicence: CC BY

Mental health in people with Parkinson’s disease during the COVID-19 pandemicFinal published version, 1.17 MBLicence: CC BY

Cite this

Dommershuijsen, L. J., Van der Heide, A., Van den Berg, E. M., Labrecque, J. A., Ikram, M. K., Ikram, M. A., Bloem, B. R., Helmich, R. C., & Darweesh, S. K. L. (2021). Mental health in people with Parkinson’s disease during the COVID-19 pandemic: potential for targeted interventions? npj Parkinson's Disease, 7(1), Article 95. https://doi.org/10.1038/s41531-021-00238-y

@article{e881ae70d057482da675518be69d8832,

title = "Mental health in people with Parkinson{\textquoteright}s disease during the COVID-19 pandemic: potential for targeted interventions?",

abstract = "The COVID-19 pandemic has introduced a myriad of challenges to the social life and care of people with Parkinson{\textquoteright}s disease (PD), which could potentially worsen mental health problems. We used baseline data of the PRIME-NL study (N = 844) to examine whether the association between COVID-19 stressors and mental health is disproportionately large in specific subgroups of people with PD and to explore effects of hypothetical reductions in COVID-19 stressors on mental health and quality of life. The mean (SD) age of the study population was 70.3 (7.8) years and 321 (38.0%) were women. The linear regression effect estimate of the association of COVID-19 stressors with mental health was most pronounced in women, highly educated people, people with advanced PD and people prone to distancing or seeking social support. Smaller effect estimates were found in people scoring high on confrontive coping or planful problem solving. The parametric G-formula method was used to calculate the effects of hypothetical interventions on COVID-19 stressors. An intervention reducing stressors with 50% in people with above median MDS-UPDRS-II decreased the Beck Depression Inventory in this group from 14.7 to 10.6, the State-Trait Anxiety Inventory from 81.6 to 73.1 and the Parkinson{\textquoteright}s Disease Quality of Life Questionnaire from 35.0 to 24.3. Insights from this cross-sectional study help to inform tailored care interventions to subgroups of people with PD most vulnerable to the impact of COVID-19 on mental health and quality of life.",

author = "Dommershuijsen, {L. J.} and {Van der Heide}, A. and {Van den Berg}, {E. M.} and Labrecque, {J. A.} and Ikram, {M. K.} and Ikram, {M. A.} and Bloem, {B. R.} and Helmich, {R. C.} and Darweesh, {S. K.L.}",

note = "Funding Information: This research is part of the collaborative Proactive and Integrated Management and Empowerment in Parkinson{\textquoteright}s Disease (PRIME Parkinson) project, which is a healthcare innovation project in selected areas of the United Kingdom and the Netherlands. The PRIME Parkinson project is financed by the Gatsby Foundation and co-funded by the PPP Allowance made available by Health~Holland, Top Sector Life Sciences & Health, to stimulate public-private partnerships. S.K.L.D. was supported in part by a Parkinson{\textquoteright}s Foundation–Postdoctoral Fellowship (PF-FBS-2026). M.K.I., M.A.I., and L. J.D. were supported in part by a Stichting Parkinson Fonds grant. B.R.B. currently serves as co-Editor in Chief for the Journal of Parkinson{\textquoteright}s disease, serves on the editorial of Practical Neurology and Digital Biomarkers, has received honoraria from serving on the scientific advisory board for Abbvie, Biogen and UCB, has received fees for speaking at conferences from AbbVie, Zambon, Roche, GE Healthcare and Bial, and has received research support from the Netherlands Organization for Scientific Research, the Michael J Fox Foundation, UCB, Abbvie, the Stichting Parkinson Fonds, the Hersenstichting Nederland, the Parkinson{\textquoteright}s Foundation, Verily Life Sciences, Horizon 2020 and the Parkinson Vereniging. Publisher Copyright: {\textcopyright} 2021, The Author(s).",

year = "2021",

month = dec,

doi = "10.1038/s41531-021-00238-y",

language = "English",

volume = "7",

journal = "npj Parkinson's Disease",

issn = "2373-8057",

publisher = "Springer Nature",

number = "1",

}

TY - JOUR

T1 - Mental health in people with Parkinson’s disease during the COVID-19 pandemic

T2 - potential for targeted interventions?

AU - Dommershuijsen, L. J.

AU - Van der Heide, A.

AU - Van den Berg, E. M.

AU - Labrecque, J. A.

AU - Ikram, M. K.

AU - Ikram, M. A.

AU - Bloem, B. R.

AU - Helmich, R. C.

AU - Darweesh, S. K.L.

N1 - Funding Information: This research is part of the collaborative Proactive and Integrated Management and Empowerment in Parkinson’s Disease (PRIME Parkinson) project, which is a healthcare innovation project in selected areas of the United Kingdom and the Netherlands. The PRIME Parkinson project is financed by the Gatsby Foundation and co-funded by the PPP Allowance made available by Health~Holland, Top Sector Life Sciences & Health, to stimulate public-private partnerships. S.K.L.D. was supported in part by a Parkinson’s Foundation–Postdoctoral Fellowship (PF-FBS-2026). M.K.I., M.A.I., and L. J.D. were supported in part by a Stichting Parkinson Fonds grant. B.R.B. currently serves as co-Editor in Chief for the Journal of Parkinson’s disease, serves on the editorial of Practical Neurology and Digital Biomarkers, has received honoraria from serving on the scientific advisory board for Abbvie, Biogen and UCB, has received fees for speaking at conferences from AbbVie, Zambon, Roche, GE Healthcare and Bial, and has received research support from the Netherlands Organization for Scientific Research, the Michael J Fox Foundation, UCB, Abbvie, the Stichting Parkinson Fonds, the Hersenstichting Nederland, the Parkinson’s Foundation, Verily Life Sciences, Horizon 2020 and the Parkinson Vereniging. Publisher Copyright: © 2021, The Author(s).

PY - 2021/12

Y1 - 2021/12

N2 - The COVID-19 pandemic has introduced a myriad of challenges to the social life and care of people with Parkinson’s disease (PD), which could potentially worsen mental health problems. We used baseline data of the PRIME-NL study (N = 844) to examine whether the association between COVID-19 stressors and mental health is disproportionately large in specific subgroups of people with PD and to explore effects of hypothetical reductions in COVID-19 stressors on mental health and quality of life. The mean (SD) age of the study population was 70.3 (7.8) years and 321 (38.0%) were women. The linear regression effect estimate of the association of COVID-19 stressors with mental health was most pronounced in women, highly educated people, people with advanced PD and people prone to distancing or seeking social support. Smaller effect estimates were found in people scoring high on confrontive coping or planful problem solving. The parametric G-formula method was used to calculate the effects of hypothetical interventions on COVID-19 stressors. An intervention reducing stressors with 50% in people with above median MDS-UPDRS-II decreased the Beck Depression Inventory in this group from 14.7 to 10.6, the State-Trait Anxiety Inventory from 81.6 to 73.1 and the Parkinson’s Disease Quality of Life Questionnaire from 35.0 to 24.3. Insights from this cross-sectional study help to inform tailored care interventions to subgroups of people with PD most vulnerable to the impact of COVID-19 on mental health and quality of life.

AB - The COVID-19 pandemic has introduced a myriad of challenges to the social life and care of people with Parkinson’s disease (PD), which could potentially worsen mental health problems. We used baseline data of the PRIME-NL study (N = 844) to examine whether the association between COVID-19 stressors and mental health is disproportionately large in specific subgroups of people with PD and to explore effects of hypothetical reductions in COVID-19 stressors on mental health and quality of life. The mean (SD) age of the study population was 70.3 (7.8) years and 321 (38.0%) were women. The linear regression effect estimate of the association of COVID-19 stressors with mental health was most pronounced in women, highly educated people, people with advanced PD and people prone to distancing or seeking social support. Smaller effect estimates were found in people scoring high on confrontive coping or planful problem solving. The parametric G-formula method was used to calculate the effects of hypothetical interventions on COVID-19 stressors. An intervention reducing stressors with 50% in people with above median MDS-UPDRS-II decreased the Beck Depression Inventory in this group from 14.7 to 10.6, the State-Trait Anxiety Inventory from 81.6 to 73.1 and the Parkinson’s Disease Quality of Life Questionnaire from 35.0 to 24.3. Insights from this cross-sectional study help to inform tailored care interventions to subgroups of people with PD most vulnerable to the impact of COVID-19 on mental health and quality of life.

UR - http://www.scopus.com/inward/record.url?scp=85118350306&partnerID=8YFLogxK

U2 - 10.1038/s41531-021-00238-y

DO - 10.1038/s41531-021-00238-y

M3 - Article

C2 - 34711842

AN - SCOPUS:85118350306

SN - 2373-8057

VL - 7

JO - npj Parkinson's Disease

JF - npj Parkinson's Disease

IS - 1

M1 - 95

ER -

Mental health in people with Parkinson’s disease during the COVID-19 pandemic: potential for targeted interventions?

Abstract

Bibliographical note

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this