Mesenchymal stem cell-educated macrophages

Elke Eggenhofer*, Martin J. Hoogduijn

*Corresponding author for this work

Research output: Contribution to journalReview articlePopular

128 Citations (Scopus)

Abstract

Mesenchymal stem cells (MSC) mediate their immunosuppressive effects via a variety of mechanisms. One of these mechanisms involves the induction of macrophages with immunomodulatory capacities. This effect of MSC may be exploited when MSC are used as a cell therapeutic product. Furthermore, MSC are resident in tissues where they may locally target infiltrating macrophages to adapt more regulatory properties. The present review discusses the interaction between MSC and macrophages, the induction of MSC-educated macrophages, how these cells position between other immune regulatory cells, and how they may be used in the clinic.

Original languageEnglish
Article number12
JournalTransplantation Research
Volume1
Issue number1
DOIs
Publication statusPublished - 28 Sep 2012

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