TY - JOUR
T1 - Mesenchymal stem cell-educated macrophages
AU - Eggenhofer, Elke
AU - Hoogduijn, Martin J.
PY - 2012/9/28
Y1 - 2012/9/28
N2 - Mesenchymal stem cells (MSC) mediate their immunosuppressive effects via a variety of mechanisms. One of these mechanisms involves the induction of macrophages with immunomodulatory capacities. This effect of MSC may be exploited when MSC are used as a cell therapeutic product. Furthermore, MSC are resident in tissues where they may locally target infiltrating macrophages to adapt more regulatory properties. The present review discusses the interaction between MSC and macrophages, the induction of MSC-educated macrophages, how these cells position between other immune regulatory cells, and how they may be used in the clinic.
AB - Mesenchymal stem cells (MSC) mediate their immunosuppressive effects via a variety of mechanisms. One of these mechanisms involves the induction of macrophages with immunomodulatory capacities. This effect of MSC may be exploited when MSC are used as a cell therapeutic product. Furthermore, MSC are resident in tissues where they may locally target infiltrating macrophages to adapt more regulatory properties. The present review discusses the interaction between MSC and macrophages, the induction of MSC-educated macrophages, how these cells position between other immune regulatory cells, and how they may be used in the clinic.
UR - http://www.scopus.com/inward/record.url?scp=84922272946&partnerID=8YFLogxK
U2 - 10.1186/2047-1440-1-12
DO - 10.1186/2047-1440-1-12
M3 - Review article
AN - SCOPUS:84922272946
SN - 2047-1440
VL - 1
JO - Transplantation Research
JF - Transplantation Research
IS - 1
M1 - 12
ER -