Meta-analyse: intelligentie van kinderen na chemotherapie wegens leukemie

S C Cao; J S Legerstee; M van Bellinghen; M Danckaerts; B Dierckx

Meta-analyse: intelligentie van kinderen na chemotherapie wegens leukemie

Translated title of the contribution: Meta-analysis: effect of chemotherapy on intelligence of children treated for leukemia

S C Cao
, J S Legerstee
, M van Bellinghen
, M Danckaerts
, B Dierckx

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

BACKGROUND: Leukemia is the most common pediatric malignancy. Acute lymphoblastic leukemia (ALL) is the most commonly observed subtype.

AIM: To assess cognitive functioning in children and adolescents with ALL post-treatment: chemotherapy-only (CT-only) or in combination with radiation therapy (CTRT). METHODS We searched in PubMed and PsycINFO (OvidSP). Relevant data were analyzed using statistical program Comprehensive Meta-Analysis (version 2).

RESULTS: 44 studies were included in the overall meta-analysis with a total of 5059 patients. A weighted mean IQ of 100.1 (95% CI 99.1-101.0) was found overall after ALL treatment. In subanalyses, we found for CT-only a weighted mean IQ of 100.7 (95% CI: 99.5-101.9) and for CTRT-treatment a weighted mean IQ of 98.2 (95%100.7 (95% CI: 96.3-100.3). There was no significant difference from the normative control (mean: 100.0; SD: 15).

CONCLUSION: No significant cognitive sequelae were shown in childhood survivors of leukemia who were exposed to either CT-only or CTRT therapy. Prospective studies are needed with inclusion of pre-and post-treatment IQ measurements, ideally compared to age and socio-economic status matched control groups.

Translated title of the contribution	Meta-analysis: effect of chemotherapy on intelligence of children treated for leukemia
Original language	Dutch
Pages (from-to)	94-100
Number of pages	7
Journal	Tijdschrift voor Psychiatrie
Volume	64
Issue number	2022-2
Publication status	Published - 10 Feb 2022

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© 2022 Uitgeverij Boom. All rights reserved.

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Cite this

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title = "Meta-analyse: intelligentie van kinderen na chemotherapie wegens leukemie",

abstract = "BACKGROUND: Leukemia is the most common pediatric malignancy. Acute lymphoblastic leukemia (ALL) is the most commonly observed subtype.AIM: To assess cognitive functioning in children and adolescents with ALL post-treatment: chemotherapy-only (CT-only) or in combination with radiation therapy (CTRT). METHODS We searched in PubMed and PsycINFO (OvidSP). Relevant data were analyzed using statistical program Comprehensive Meta-Analysis (version 2).RESULTS: 44 studies were included in the overall meta-analysis with a total of 5059 patients. A weighted mean IQ of 100.1 (95\% CI 99.1-101.0) was found overall after ALL treatment. In subanalyses, we found for CT-only a weighted mean IQ of 100.7 (95\% CI: 99.5-101.9) and for CTRT-treatment a weighted mean IQ of 98.2 (95\%100.7 (95\% CI: 96.3-100.3). There was no significant difference from the normative control (mean: 100.0; SD: 15).CONCLUSION: No significant cognitive sequelae were shown in childhood survivors of leukemia who were exposed to either CT-only or CTRT therapy. Prospective studies are needed with inclusion of pre-and post-treatment IQ measurements, ideally compared to age and socio-economic status matched control groups.",

author = "Cao, \{S C\} and Legerstee, \{J S\} and \{van Bellinghen\}, M and M Danckaerts and B Dierckx",

year = "2022",

month = feb,

day = "10",

language = "Dutch",

volume = "64",

pages = "94--100",

journal = "Tijdschrift voor Psychiatrie",

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TY - JOUR

T1 - Meta-analyse

T2 - intelligentie van kinderen na chemotherapie wegens leukemie

AU - Cao, S C

AU - Legerstee, J S

AU - van Bellinghen, M

AU - Danckaerts, M

AU - Dierckx, B

PY - 2022/2/10

Y1 - 2022/2/10

N2 - BACKGROUND: Leukemia is the most common pediatric malignancy. Acute lymphoblastic leukemia (ALL) is the most commonly observed subtype.AIM: To assess cognitive functioning in children and adolescents with ALL post-treatment: chemotherapy-only (CT-only) or in combination with radiation therapy (CTRT). METHODS We searched in PubMed and PsycINFO (OvidSP). Relevant data were analyzed using statistical program Comprehensive Meta-Analysis (version 2).RESULTS: 44 studies were included in the overall meta-analysis with a total of 5059 patients. A weighted mean IQ of 100.1 (95% CI 99.1-101.0) was found overall after ALL treatment. In subanalyses, we found for CT-only a weighted mean IQ of 100.7 (95% CI: 99.5-101.9) and for CTRT-treatment a weighted mean IQ of 98.2 (95%100.7 (95% CI: 96.3-100.3). There was no significant difference from the normative control (mean: 100.0; SD: 15).CONCLUSION: No significant cognitive sequelae were shown in childhood survivors of leukemia who were exposed to either CT-only or CTRT therapy. Prospective studies are needed with inclusion of pre-and post-treatment IQ measurements, ideally compared to age and socio-economic status matched control groups.

AB - BACKGROUND: Leukemia is the most common pediatric malignancy. Acute lymphoblastic leukemia (ALL) is the most commonly observed subtype.AIM: To assess cognitive functioning in children and adolescents with ALL post-treatment: chemotherapy-only (CT-only) or in combination with radiation therapy (CTRT). METHODS We searched in PubMed and PsycINFO (OvidSP). Relevant data were analyzed using statistical program Comprehensive Meta-Analysis (version 2).RESULTS: 44 studies were included in the overall meta-analysis with a total of 5059 patients. A weighted mean IQ of 100.1 (95% CI 99.1-101.0) was found overall after ALL treatment. In subanalyses, we found for CT-only a weighted mean IQ of 100.7 (95% CI: 99.5-101.9) and for CTRT-treatment a weighted mean IQ of 98.2 (95%100.7 (95% CI: 96.3-100.3). There was no significant difference from the normative control (mean: 100.0; SD: 15).CONCLUSION: No significant cognitive sequelae were shown in childhood survivors of leukemia who were exposed to either CT-only or CTRT therapy. Prospective studies are needed with inclusion of pre-and post-treatment IQ measurements, ideally compared to age and socio-economic status matched control groups.

UR - https://www.scopus.com/pages/publications/85128274951

M3 - Article

C2 - 35420152

SN - 0303-7339

VL - 64

SP - 94

EP - 100

JO - Tijdschrift voor Psychiatrie

JF - Tijdschrift voor Psychiatrie

IS - 2022-2

ER -

Meta-analyse: intelligentie van kinderen na chemotherapie wegens leukemie

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