Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function

DB Hancock; Mark Eijgelsheim; JB Wilk; SA Gharib; LR Loehr; KD Marciante; N Franceschini; YMTA van Durme; TH Chen; RG Barr; MB Schabath; DJ Couper; Guy Brusselle; BM Psaty; Cornelia Duijn; JI Rotter; André Uitterlinden; Bert Hofman; NM Punjabi; Fernando Rivadeneira; AC Morrison; PL Enright; KE North; SR Heckbert; T Lumley; Bruno Stricker; GT O'Connor; SJ London

doi:10.1038/ng.500

Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function

DB Hancock, Mark Eijgelsheim, JB Wilk, SA Gharib, LR Loehr, KD Marciante, N Franceschini, YMTA van Durme, TH Chen, RG Barr, MB Schabath, DJ Couper, Guy Brusselle, BM Psaty, Cornelia Duijn, JI Rotter, André Uitterlinden, Bert Hofman, NM Punjabi, Fernando RivadeneiraAC Morrison, PL Enright, KE North, SR Heckbert, T Lumley, Bruno Stricker, GT O'Connor, SJ London

Research output: Contribution to journal › Article › Academic › peer-review

526 Citations (Scopus)

Abstract

Spirometric measures of lung function are heritable traits that reflect respiratory health and predict morbidity and mortality. We meta-analyzed genome-wide association studies for two clinically important lung-function measures: forced expiratory volume in the first second (FEV1) and its ratio to forced vital capacity (FEV1/FVC), an indicator of airflow obstruction. This meta-analysis included 20,890 participants of European ancestry from four CHARGE Consortium studies: Atherosclerosis Risk in Communities, Cardiovascular Health Study, Framingham Heart Study and Rotterdam Study. We identified eight loci associated with FEV1/FVC (HHIP, GPR126, ADAM19, AGER-PPT2, FAM13A, PTCH1, PID1 and HTR4) and one locus associated with FEV1 (INTS12-GSTCD-NPNT) at or near genome-wide significance (P < 5 x 10(-8)) in the CHARGE Consortium dataset. Our findings may offer insights into pulmonary function and pathogenesis of chronic lung disease.

Original language	Undefined/Unknown
Pages (from-to)	45-U61
Journal	Nature Genetics
Volume	42
Issue number	1
DOIs	https://doi.org/10.1038/ng.500
Publication status	Published - 2010

Research programs

EMC MM-01-39-02
EMC NIHES-01-64-01
EMC NIHES-01-64-02
EMC NIHES-01-64-03
EMC NIHES-03-77-02

Access to Document

10.1038/ng.500

http://hdl.handle.net/1765/28288

Cite this

Hancock, DB., Eijgelsheim, M., Wilk, JB., Gharib, SA., Loehr, LR., Marciante, KD., Franceschini, N., van Durme, YMTA., Chen, TH., Barr, RG., Schabath, MB., Couper, DJ., Brusselle, G., Psaty, BM., Duijn, C., Rotter, JI., Uitterlinden, A., Hofman, B., Punjabi, NM., ... London, SJ. (2010). Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function. Nature Genetics, 42(1), 45-U61. https://doi.org/10.1038/ng.500

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title = "Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function",

abstract = "Spirometric measures of lung function are heritable traits that reflect respiratory health and predict morbidity and mortality. We meta-analyzed genome-wide association studies for two clinically important lung-function measures: forced expiratory volume in the first second (FEV1) and its ratio to forced vital capacity (FEV1/FVC), an indicator of airflow obstruction. This meta-analysis included 20,890 participants of European ancestry from four CHARGE Consortium studies: Atherosclerosis Risk in Communities, Cardiovascular Health Study, Framingham Heart Study and Rotterdam Study. We identified eight loci associated with FEV1/FVC (HHIP, GPR126, ADAM19, AGER-PPT2, FAM13A, PTCH1, PID1 and HTR4) and one locus associated with FEV1 (INTS12-GSTCD-NPNT) at or near genome-wide significance (P < 5 x 10(-8)) in the CHARGE Consortium dataset. Our findings may offer insights into pulmonary function and pathogenesis of chronic lung disease.",

author = "DB Hancock and Mark Eijgelsheim and JB Wilk and SA Gharib and LR Loehr and KD Marciante and N Franceschini and {van Durme}, YMTA and TH Chen and RG Barr and MB Schabath and DJ Couper and Guy Brusselle and BM Psaty and Cornelia Duijn and JI Rotter and Andr{\'e} Uitterlinden and Bert Hofman and NM Punjabi and Fernando Rivadeneira and AC Morrison and PL Enright and KE North and SR Heckbert and T Lumley and Bruno Stricker and GT O'Connor and SJ London",

year = "2010",

doi = "10.1038/ng.500",

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Hancock, DB, Eijgelsheim, M, Wilk, JB, Gharib, SA, Loehr, LR, Marciante, KD, Franceschini, N, van Durme, YMTA, Chen, TH, Barr, RG, Schabath, MB, Couper, DJ, Brusselle, G, Psaty, BM, Duijn, C, Rotter, JI, Uitterlinden, A , Hofman, B, Punjabi, NM, Rivadeneira, F, Morrison, AC, Enright, PL, North, KE, Heckbert, SR, Lumley, T, Stricker, B, O'Connor, GT & London, SJ 2010, 'Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function', Nature Genetics, vol. 42, no. 1, pp. 45-U61. https://doi.org/10.1038/ng.500

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T1 - Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function

AU - Hancock, DB

AU - Eijgelsheim, Mark

AU - Wilk, JB

AU - Gharib, SA

AU - Loehr, LR

AU - Marciante, KD

AU - Franceschini, N

AU - van Durme, YMTA

AU - Chen, TH

AU - Barr, RG

AU - Schabath, MB

AU - Couper, DJ

AU - Brusselle, Guy

AU - Psaty, BM

AU - Duijn, Cornelia

AU - Rotter, JI

AU - Uitterlinden, André

AU - Hofman, Bert

AU - Punjabi, NM

AU - Rivadeneira, Fernando

AU - Morrison, AC

AU - Enright, PL

AU - North, KE

AU - Heckbert, SR

AU - Lumley, T

AU - Stricker, Bruno

AU - O'Connor, GT

AU - London, SJ

PY - 2010

Y1 - 2010

N2 - Spirometric measures of lung function are heritable traits that reflect respiratory health and predict morbidity and mortality. We meta-analyzed genome-wide association studies for two clinically important lung-function measures: forced expiratory volume in the first second (FEV1) and its ratio to forced vital capacity (FEV1/FVC), an indicator of airflow obstruction. This meta-analysis included 20,890 participants of European ancestry from four CHARGE Consortium studies: Atherosclerosis Risk in Communities, Cardiovascular Health Study, Framingham Heart Study and Rotterdam Study. We identified eight loci associated with FEV1/FVC (HHIP, GPR126, ADAM19, AGER-PPT2, FAM13A, PTCH1, PID1 and HTR4) and one locus associated with FEV1 (INTS12-GSTCD-NPNT) at or near genome-wide significance (P < 5 x 10(-8)) in the CHARGE Consortium dataset. Our findings may offer insights into pulmonary function and pathogenesis of chronic lung disease.

AB - Spirometric measures of lung function are heritable traits that reflect respiratory health and predict morbidity and mortality. We meta-analyzed genome-wide association studies for two clinically important lung-function measures: forced expiratory volume in the first second (FEV1) and its ratio to forced vital capacity (FEV1/FVC), an indicator of airflow obstruction. This meta-analysis included 20,890 participants of European ancestry from four CHARGE Consortium studies: Atherosclerosis Risk in Communities, Cardiovascular Health Study, Framingham Heart Study and Rotterdam Study. We identified eight loci associated with FEV1/FVC (HHIP, GPR126, ADAM19, AGER-PPT2, FAM13A, PTCH1, PID1 and HTR4) and one locus associated with FEV1 (INTS12-GSTCD-NPNT) at or near genome-wide significance (P < 5 x 10(-8)) in the CHARGE Consortium dataset. Our findings may offer insights into pulmonary function and pathogenesis of chronic lung disease.

U2 - 10.1038/ng.500

DO - 10.1038/ng.500

M3 - Article

C2 - 20010835

SN - 1061-4036

VL - 42

SP - 45-U61

JO - Nature Genetics

JF - Nature Genetics

IS - 1

ER -