Meta-analysis comparing carvedilol versus metoprolol for the prevention of postoperative atrial fibrillation following coronary artery bypass grafting

James J. Dinicolantonio; Craig J. Beavers; Arthur R. Menezes; Carl J. Lavie; James H. O'Keefe; Pascal Meier; András Vorobcsuk; Dániel Aradi; András Komócsi; Saurav Chatterjee; Fabrizio D'Ascenzo; Mauro Gasparini; Jasper Brugts; Giuseppe Biondi-Zoccai

doi:10.1016/j.amjcard.2013.10.020

Meta-analysis comparing carvedilol versus metoprolol for the prevention of postoperative atrial fibrillation following coronary artery bypass grafting

James J. Dinicolantonio^*, Craig J. Beavers, Arthur R. Menezes, Carl J. Lavie, James H. O'Keefe, Pascal Meier, András Vorobcsuk, Dániel Aradi, András Komócsi, Saurav Chatterjee, Fabrizio D'Ascenzo, Mauro Gasparini, Jasper Brugts, Giuseppe Biondi-Zoccai

^*Corresponding author for this work

Cardiology

Research output: Contribution to journal › Review article › Academic › peer-review

37 Citations (Scopus)

Abstract

A systematic review and meta-analysis was performed to evaluate the effects of carvedilol versus metoprolol on the incidence of postoperative atrial fibrillation in patients undergoing coronary artery bypass grafting in randomized controlled trials. Ovid MEDLINE, PubMed, CENTRAL, and Excepta Medica (EMBASE) were searched up to March 2013 for suitable randomized controlled trials. Data were pooled using random-effects model for pairwise analyses. A total of 4 trials with 601 patients were included in this analysis. Pairwise analyses showed that compared with metoprolol, carvedilol significantly reduced the incidence of postoperative atrial fibrillation (odds ratio 0.50, 95% confidence interval 0.32 to 0.80). In conclusion, compared with metoprolol, carvedilol significantly reduces the incidence of postoperative atrial fibrillation in patients undergoing coronary artery bypass grafting.

Original language	English
Pages (from-to)	565-569
Number of pages	5
Journal	American Journal of Cardiology
Volume	113
Issue number	3
DOIs	https://doi.org/10.1016/j.amjcard.2013.10.020
Publication status	Published - 1 Feb 2014

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10.1016/j.amjcard.2013.10.020

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Dinicolantonio, J. J., Beavers, C. J., Menezes, A. R., Lavie, C. J., O'Keefe, J. H., Meier, P., Vorobcsuk, A., Aradi, D., Komócsi, A., Chatterjee, S., D'Ascenzo, F., Gasparini, M., Brugts, J., & Biondi-Zoccai, G. (2014). Meta-analysis comparing carvedilol versus metoprolol for the prevention of postoperative atrial fibrillation following coronary artery bypass grafting. American Journal of Cardiology, 113(3), 565-569. https://doi.org/10.1016/j.amjcard.2013.10.020

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title = "Meta-analysis comparing carvedilol versus metoprolol for the prevention of postoperative atrial fibrillation following coronary artery bypass grafting",

abstract = "A systematic review and meta-analysis was performed to evaluate the effects of carvedilol versus metoprolol on the incidence of postoperative atrial fibrillation in patients undergoing coronary artery bypass grafting in randomized controlled trials. Ovid MEDLINE, PubMed, CENTRAL, and Excepta Medica (EMBASE) were searched up to March 2013 for suitable randomized controlled trials. Data were pooled using random-effects model for pairwise analyses. A total of 4 trials with 601 patients were included in this analysis. Pairwise analyses showed that compared with metoprolol, carvedilol significantly reduced the incidence of postoperative atrial fibrillation (odds ratio 0.50, 95% confidence interval 0.32 to 0.80). In conclusion, compared with metoprolol, carvedilol significantly reduces the incidence of postoperative atrial fibrillation in patients undergoing coronary artery bypass grafting.",

author = "Dinicolantonio, {James J.} and Beavers, {Craig J.} and Menezes, {Arthur R.} and Lavie, {Carl J.} and O'Keefe, {James H.} and Pascal Meier and Andr{\'a}s Vorobcsuk and D{\'a}niel Aradi and Andr{\'a}s Kom{\'o}csi and Saurav Chatterjee and Fabrizio D'Ascenzo and Mauro Gasparini and Jasper Brugts and Giuseppe Biondi-Zoccai",

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doi = "10.1016/j.amjcard.2013.10.020",

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Dinicolantonio, JJ, Beavers, CJ, Menezes, AR, Lavie, CJ, O'Keefe, JH, Meier, P, Vorobcsuk, A, Aradi, D, Komócsi, A, Chatterjee, S, D'Ascenzo, F, Gasparini, M, Brugts, J & Biondi-Zoccai, G 2014, 'Meta-analysis comparing carvedilol versus metoprolol for the prevention of postoperative atrial fibrillation following coronary artery bypass grafting', American Journal of Cardiology, vol. 113, no. 3, pp. 565-569. https://doi.org/10.1016/j.amjcard.2013.10.020

Meta-analysis comparing carvedilol versus metoprolol for the prevention of postoperative atrial fibrillation following coronary artery bypass grafting. / Dinicolantonio, James J.; Beavers, Craig J.; Menezes, Arthur R. et al.
In: American Journal of Cardiology, Vol. 113, No. 3, 01.02.2014, p. 565-569.

Research output: Contribution to journal › Review article › Academic › peer-review

TY - JOUR

T1 - Meta-analysis comparing carvedilol versus metoprolol for the prevention of postoperative atrial fibrillation following coronary artery bypass grafting

AU - Dinicolantonio, James J.

AU - Beavers, Craig J.

AU - Menezes, Arthur R.

AU - Lavie, Carl J.

AU - O'Keefe, James H.

AU - Meier, Pascal

AU - Vorobcsuk, András

AU - Aradi, Dániel

AU - Komócsi, András

AU - Chatterjee, Saurav

AU - D'Ascenzo, Fabrizio

AU - Gasparini, Mauro

AU - Brugts, Jasper

AU - Biondi-Zoccai, Giuseppe

PY - 2014/2/1

Y1 - 2014/2/1

N2 - A systematic review and meta-analysis was performed to evaluate the effects of carvedilol versus metoprolol on the incidence of postoperative atrial fibrillation in patients undergoing coronary artery bypass grafting in randomized controlled trials. Ovid MEDLINE, PubMed, CENTRAL, and Excepta Medica (EMBASE) were searched up to March 2013 for suitable randomized controlled trials. Data were pooled using random-effects model for pairwise analyses. A total of 4 trials with 601 patients were included in this analysis. Pairwise analyses showed that compared with metoprolol, carvedilol significantly reduced the incidence of postoperative atrial fibrillation (odds ratio 0.50, 95% confidence interval 0.32 to 0.80). In conclusion, compared with metoprolol, carvedilol significantly reduces the incidence of postoperative atrial fibrillation in patients undergoing coronary artery bypass grafting.

AB - A systematic review and meta-analysis was performed to evaluate the effects of carvedilol versus metoprolol on the incidence of postoperative atrial fibrillation in patients undergoing coronary artery bypass grafting in randomized controlled trials. Ovid MEDLINE, PubMed, CENTRAL, and Excepta Medica (EMBASE) were searched up to March 2013 for suitable randomized controlled trials. Data were pooled using random-effects model for pairwise analyses. A total of 4 trials with 601 patients were included in this analysis. Pairwise analyses showed that compared with metoprolol, carvedilol significantly reduced the incidence of postoperative atrial fibrillation (odds ratio 0.50, 95% confidence interval 0.32 to 0.80). In conclusion, compared with metoprolol, carvedilol significantly reduces the incidence of postoperative atrial fibrillation in patients undergoing coronary artery bypass grafting.

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EP - 569

JO - American Journal of Cardiology

JF - American Journal of Cardiology

IS - 3

ER -

Meta-analysis comparing carvedilol versus metoprolol for the prevention of postoperative atrial fibrillation following coronary artery bypass grafting

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