Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations

Y Okada; X Sim; MJ Go; JY Wu; DF Gu; F Takeuchi; A Takahashi; S Maeda; T Tsunoda; Peng Chen; SC Lim; TY (Tien Yin) Wong; JJ Liu; TL Young; T Aung; M Seielstad; YY Teo; YJ Kim; JY Lee; BG Han; D Kang; C (Christopher Li Hsian) Chen; FJ Tsai; LC Chang; SJC Fann; Hailang Mei; DC Rao; JE Hixson; SF Chen; T Katsuya; M Isono; T Ogihara; JC Chambers; WH Zhang; JS Kooner; E Albrecht; K Yamamoto; M Kubo; Y Nakamura; N Kamatani; N Kato; H He; YT Chen; YS Cho; ES Tai; T Tanaka

doi:10.1038/ng.2352

Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations

Y Okada, X Sim, MJ Go, JY Wu, DF Gu, F Takeuchi, A Takahashi, S Maeda, T Tsunoda, Peng Chen, SC Lim, TY (Tien Yin) Wong, JJ Liu, TL Young, T Aung, M Seielstad, YY Teo, YJ Kim, JY Lee, BG HanD Kang, C (Christopher Li Hsian) Chen, FJ Tsai, LC Chang, SJC Fann, Hailang Mei, DC Rao, JE Hixson, SF Chen, T Katsuya, M Isono, T Ogihara, JC Chambers, WH Zhang, JS Kooner, E Albrecht, K Yamamoto, M Kubo, Y Nakamura, N Kamatani, N Kato, H He, YT Chen, YS Cho, ES Tai, T Tanaka

Research output: Contribution to journal › Article › Academic › peer-review

240 Citations (Scopus)

Abstract

Chronic kidney disease (CKD), impairment of kidney function, is a serious public health problem, and the assessment of genetic factors influencing kidney function has substantial clinical relevance. Here, we report a meta-analysis of genomewide association studies for kidney function-related traits, including 71,149 east Asian individuals from 18 studies in 11 population-, hospital- or family-based cohorts, conducted as part of the Asian Genetic Epidemiology Network (AGEN). Our meta-analysis identified 17 loci newly associated with kidney function-related traits, including the concentrations of blood urea nitrogen, uric acid and serum creatinine and estimated glomerular filtration rate based on serum creatinine levels (eGFRcrea) (P < 5.0 x 10(-8)). We further examined these loci with in silico replication in individuals of European ancestry from the KidneyGen, CKDGen and GUGC consortia, including a combined total of similar to 110,347 individuals. We identify pleiotropic associations among these loci with kidney function-related traits and risk of CKD. These findings provide new insights into the genetics of kidney function.

Original language	Undefined/Unknown
Pages (from-to)	904-+
Journal	Nature Genetics
Volume	44
Issue number	8
DOIs	https://doi.org/10.1038/ng.2352
Publication status	Published - 2012

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10.1038/ng.2352

Cite this

Okada, Y., Sim, X., Go, MJ., Wu, JY., Gu, DF., Takeuchi, F., Takahashi, A., Maeda, S., Tsunoda, T., Chen, P., Lim, SC., Wong, TY., Liu, JJ., Young, TL., Aung, T., Seielstad, M., Teo, YY., Kim, YJ., Lee, JY., ... Tanaka, T. (2012). Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations. Nature Genetics, 44(8), 904-+. https://doi.org/10.1038/ng.2352

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title = "Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations",

abstract = "Chronic kidney disease (CKD), impairment of kidney function, is a serious public health problem, and the assessment of genetic factors influencing kidney function has substantial clinical relevance. Here, we report a meta-analysis of genomewide association studies for kidney function-related traits, including 71,149 east Asian individuals from 18 studies in 11 population-, hospital- or family-based cohorts, conducted as part of the Asian Genetic Epidemiology Network (AGEN). Our meta-analysis identified 17 loci newly associated with kidney function-related traits, including the concentrations of blood urea nitrogen, uric acid and serum creatinine and estimated glomerular filtration rate based on serum creatinine levels (eGFRcrea) (P < 5.0 x 10(-8)). We further examined these loci with in silico replication in individuals of European ancestry from the KidneyGen, CKDGen and GUGC consortia, including a combined total of similar to 110,347 individuals. We identify pleiotropic associations among these loci with kidney function-related traits and risk of CKD. These findings provide new insights into the genetics of kidney function.",

author = "Y Okada and X Sim and MJ Go and JY Wu and DF Gu and F Takeuchi and A Takahashi and S Maeda and T Tsunoda and Peng Chen and SC Lim and Wong, {TY (Tien Yin)} and JJ Liu and TL Young and T Aung and M Seielstad and YY Teo and YJ Kim and JY Lee and BG Han and D Kang and Chen, {C (Christopher Li Hsian)} and FJ Tsai and LC Chang and SJC Fann and Hailang Mei and DC Rao and JE Hixson and SF Chen and T Katsuya and M Isono and T Ogihara and JC Chambers and WH Zhang and JS Kooner and E Albrecht and K Yamamoto and M Kubo and Y Nakamura and N Kamatani and N Kato and H He and YT Chen and YS Cho and ES Tai and T Tanaka",

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Okada, Y, Sim, X, Go, MJ, Wu, JY, Gu, DF, Takeuchi, F, Takahashi, A, Maeda, S, Tsunoda, T, Chen, P, Lim, SC, Wong, TY, Liu, JJ, Young, TL, Aung, T, Seielstad, M, Teo, YY, Kim, YJ, Lee, JY, Han, BG, Kang, D, Chen, C, Tsai, FJ, Chang, LC, Fann, SJC, Mei, H, Rao, DC, Hixson, JE, Chen, SF, Katsuya, T, Isono, M, Ogihara, T, Chambers, JC, Zhang, WH, Kooner, JS, Albrecht, E, Yamamoto, K, Kubo, M, Nakamura, Y, Kamatani, N, Kato, N, He, H, Chen, YT, Cho, YS, Tai, ES & Tanaka, T 2012, 'Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations', Nature Genetics, vol. 44, no. 8, pp. 904-+. https://doi.org/10.1038/ng.2352

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AU - Okada, Y

AU - Sim, X

AU - Go, MJ

AU - Wu, JY

AU - Gu, DF

AU - Takeuchi, F

AU - Takahashi, A

AU - Maeda, S

AU - Tsunoda, T

AU - Chen, Peng

AU - Lim, SC

AU - Wong, TY (Tien Yin)

AU - Liu, JJ

AU - Young, TL

AU - Aung, T

AU - Seielstad, M

AU - Teo, YY

AU - Kim, YJ

AU - Lee, JY

AU - Han, BG

AU - Kang, D

AU - Chen, C (Christopher Li Hsian)

AU - Tsai, FJ

AU - Chang, LC

AU - Fann, SJC

AU - Mei, Hailang

AU - Rao, DC

AU - Hixson, JE

AU - Chen, SF

AU - Katsuya, T

AU - Isono, M

AU - Ogihara, T

AU - Chambers, JC

AU - Zhang, WH

AU - Kooner, JS

AU - Albrecht, E

AU - Yamamoto, K

AU - Kubo, M

AU - Nakamura, Y

AU - Kamatani, N

AU - Kato, N

AU - He, H

AU - Chen, YT

AU - Cho, YS

AU - Tai, ES

AU - Tanaka, T

PY - 2012

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AB - Chronic kidney disease (CKD), impairment of kidney function, is a serious public health problem, and the assessment of genetic factors influencing kidney function has substantial clinical relevance. Here, we report a meta-analysis of genomewide association studies for kidney function-related traits, including 71,149 east Asian individuals from 18 studies in 11 population-, hospital- or family-based cohorts, conducted as part of the Asian Genetic Epidemiology Network (AGEN). Our meta-analysis identified 17 loci newly associated with kidney function-related traits, including the concentrations of blood urea nitrogen, uric acid and serum creatinine and estimated glomerular filtration rate based on serum creatinine levels (eGFRcrea) (P < 5.0 x 10(-8)). We further examined these loci with in silico replication in individuals of European ancestry from the KidneyGen, CKDGen and GUGC consortia, including a combined total of similar to 110,347 individuals. We identify pleiotropic associations among these loci with kidney function-related traits and risk of CKD. These findings provide new insights into the genetics of kidney function.

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