Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations

Y Okada, X Sim, MJ Go, JY Wu, DF Gu, F Takeuchi, A Takahashi, S Maeda, T Tsunoda, Peng Chen, SC Lim, TY (Tien Yin) Wong, JJ Liu, TL Young, T Aung, M Seielstad, YY Teo, YJ Kim, JY Lee, BG HanD Kang, C (Christopher Li Hsian) Chen, FJ Tsai, LC Chang, SJC Fann, Hailang Mei, DC Rao, JE Hixson, SF Chen, T Katsuya, M Isono, T Ogihara, JC Chambers, WH Zhang, JS Kooner, E Albrecht, K Yamamoto, M Kubo, Y Nakamura, N Kamatani, N Kato, H He, YT Chen, YS Cho, ES Tai, T Tanaka

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Abstract

Chronic kidney disease (CKD), impairment of kidney function, is a serious public health problem, and the assessment of genetic factors influencing kidney function has substantial clinical relevance. Here, we report a meta-analysis of genomewide association studies for kidney function-related traits, including 71,149 east Asian individuals from 18 studies in 11 population-, hospital- or family-based cohorts, conducted as part of the Asian Genetic Epidemiology Network (AGEN). Our meta-analysis identified 17 loci newly associated with kidney function-related traits, including the concentrations of blood urea nitrogen, uric acid and serum creatinine and estimated glomerular filtration rate based on serum creatinine levels (eGFRcrea) (P < 5.0 x 10(-8)). We further examined these loci with in silico replication in individuals of European ancestry from the KidneyGen, CKDGen and GUGC consortia, including a combined total of similar to 110,347 individuals. We identify pleiotropic associations among these loci with kidney function-related traits and risk of CKD. These findings provide new insights into the genetics of kidney function.
Original languageUndefined/Unknown
Pages (from-to)904-+
JournalNature Genetics
Volume44
Issue number8
DOIs
Publication statusPublished - 2012

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