Meta-analysis identifies six new susceptibility loci for atrial fibrillation

PT Ellinor; KL Lunetta; CM Albert; NL Glazer; MD Ritchie; AV Smith; DE Arking; M Muller-Nurasyid; Bouwe Krijthe; SA Lubitz; JC Bis; MK Chung; M Doerr; K Ozaki; JD Roberts; JG Smith; A Pfeufer; MF Sinner; K Lohman; JZ (Jing Zhong) Ding; NL Smith; JD Smith; M Rienstra; KM Rice; DR Van Wagoner; JW Magnani; R Wakili; S Clauss; JI Rotter; G Steinbeck; LJ (Lenore) Launer; RW Davies; M Borkovich; TB Harris; HH Lin; U Volker; H Volzke; DJ Milan; Bert Hofman; E Boerwinkle; LY Chen; EZ Soliman; BF Voight; G (Guo) Li; A Chakravarti; M Kubo; UB Tedrow; LM Rose; PM Ridker; D Conen; T Tsunoda; T Furukawa; N Sotoodehnia; SY Xu; N Kamatani; D Levy; Y Nakamura; B Parvez; S Mahida; KL Furie; J Rosand; R Muhammad; BM Psaty; T Meitinger; S Perz; HE Wichmann; JCM Witteman; WHL Kao; S Kathiresan; DM Roden; André Uitterlinden; Fernando Rivadeneira; B McKnight; M Sjogren; AB Newman; YM Liu; MH Gollob; O Melander; T Tanaka; Bruno Stricker; SB Felix; A Alonso; D Darbar; J Barnard; DI Chasman; SR Heckbert; EJ Benjamin; V Gudnason; S Kaab

doi:10.1038/ng.2261

Meta-analysis identifies six new susceptibility loci for atrial fibrillation

PT Ellinor
, KL Lunetta
, CM Albert
, NL Glazer
, MD Ritchie
, AV Smith
, DE Arking
, M Muller-Nurasyid
, Bouwe Krijthe
, SA Lubitz
, JC Bis
, MK Chung
, M Doerr
, K Ozaki
, JD Roberts
, JG Smith
, A Pfeufer
, MF Sinner
, K Lohman
, JZ (Jing Zhong) Ding

NL Smith, JD Smith, M Rienstra, KM Rice, DR Van Wagoner, JW Magnani, R Wakili, S Clauss, JI Rotter, G Steinbeck, LJ (Lenore) Launer, RW Davies, M Borkovich, TB Harris, HH Lin, U Volker, H Volzke, DJ Milan, Bert Hofman, E Boerwinkle, LY Chen, EZ Soliman, BF Voight, G (Guo) Li, A Chakravarti, M Kubo, UB Tedrow, LM Rose, PM Ridker, D Conen, T Tsunoda, T Furukawa, N Sotoodehnia, SY Xu, N Kamatani, D Levy, Y Nakamura, B Parvez, S Mahida, KL Furie, J Rosand, R Muhammad, BM Psaty, T Meitinger, S Perz, HE Wichmann, JCM Witteman, WHL Kao, S Kathiresan, DM Roden, André Uitterlinden, Fernando Rivadeneira, B McKnight, M Sjogren, AB Newman, YM Liu, MH Gollob, O Melander, T Tanaka, Bruno Stricker, SB Felix, A Alonso, D Darbar, J Barnard, DI Chasman, SR Heckbert, EJ Benjamin, V Gudnason, S Kaab

External organisation

Research output: Contribution to journal › Article › Academic › peer-review

527 Citations (Scopus)

Abstract

Atrial fibrillation is a highly prevalent arrhythmia and a major risk factor for stroke, heart failure and death(1). We conducted a genome-wide association study (GWAS) in individuals of European ancestry, including 6,707 with and 52,426 without atrial fibrillation. Six new atrial fibrillation susceptibility loci were identified and replicated in an additional sample of individuals of European ancestry, including 5,381 subjects with and 10,030 subjects without atrial fibrillation (P < 5 x 10(-8)). Four of the loci identified in Europeans were further replicated in silico in a GWAS of Japanese individuals, including 843 individuals with and 3,350 individuals without atrial fibrillation. The identified loci implicate candidate genes that encode transcription factors related to cardiopulmonary development, cardiac-expressed ion channels and cell signaling molecules.

Original language	Undefined/Unknown
Pages (from-to)	670-U88
Journal	Nature Genetics
Volume	44
Issue number	6
DOIs	https://doi.org/10.1038/ng.2261
Publication status	Published - 2012

Research programs

EMC MM-01-39-09-A
EMC NIHES-01-64-01
EMC NIHES-03-77-02

Access to Document

10.1038/ng.2261

http://hdl.handle.net/1765/59238

Cite this

Ellinor, PT., Lunetta, KL., Albert, CM., Glazer, NL., Ritchie, MD., Smith, AV., Arking, DE., Muller-Nurasyid, M., Krijthe, B., Lubitz, SA., Bis, JC., Chung, MK., Doerr, M., Ozaki, K., Roberts, JD., Smith, JG., Pfeufer, A., Sinner, MF., Lohman, K., ... Kaab, S. (2012). Meta-analysis identifies six new susceptibility loci for atrial fibrillation. Nature Genetics, 44(6), 670-U88. https://doi.org/10.1038/ng.2261

@article{c8805c92967144bab3c0b135bfe7d66d,

title = "Meta-analysis identifies six new susceptibility loci for atrial fibrillation",

abstract = "Atrial fibrillation is a highly prevalent arrhythmia and a major risk factor for stroke, heart failure and death(1). We conducted a genome-wide association study (GWAS) in individuals of European ancestry, including 6,707 with and 52,426 without atrial fibrillation. Six new atrial fibrillation susceptibility loci were identified and replicated in an additional sample of individuals of European ancestry, including 5,381 subjects with and 10,030 subjects without atrial fibrillation (P < 5 x 10(-8)). Four of the loci identified in Europeans were further replicated in silico in a GWAS of Japanese individuals, including 843 individuals with and 3,350 individuals without atrial fibrillation. The identified loci implicate candidate genes that encode transcription factors related to cardiopulmonary development, cardiac-expressed ion channels and cell signaling molecules.",

author = "PT Ellinor and KL Lunetta and CM Albert and NL Glazer and MD Ritchie and AV Smith and DE Arking and M Muller-Nurasyid and Bouwe Krijthe and SA Lubitz and JC Bis and MK Chung and M Doerr and K Ozaki and JD Roberts and JG Smith and A Pfeufer and MF Sinner and K Lohman and Ding, \{JZ (Jing Zhong)\} and NL Smith and JD Smith and M Rienstra and KM Rice and \{Van Wagoner\}, DR and JW Magnani and R Wakili and S Clauss and JI Rotter and G Steinbeck and Launer, \{LJ (Lenore)\} and RW Davies and M Borkovich and TB Harris and HH Lin and U Volker and H Volzke and DJ Milan and Bert Hofman and E Boerwinkle and LY Chen and EZ Soliman and BF Voight and Li, \{G (Guo)\} and A Chakravarti and M Kubo and UB Tedrow and LM Rose and PM Ridker and D Conen and T Tsunoda and T Furukawa and N Sotoodehnia and SY Xu and N Kamatani and D Levy and Y Nakamura and B Parvez and S Mahida and KL Furie and J Rosand and R Muhammad and BM Psaty and T Meitinger and S Perz and HE Wichmann and JCM Witteman and WHL Kao and S Kathiresan and DM Roden and Andr{\'e} Uitterlinden and Fernando Rivadeneira and B McKnight and M Sjogren and AB Newman and YM Liu and MH Gollob and O Melander and T Tanaka and Bruno Stricker and SB Felix and A Alonso and D Darbar and J Barnard and DI Chasman and SR Heckbert and EJ Benjamin and V Gudnason and S Kaab",

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doi = "10.1038/ng.2261",

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Ellinor, PT, Lunetta, KL, Albert, CM, Glazer, NL, Ritchie, MD, Smith, AV, Arking, DE, Muller-Nurasyid, M, Krijthe, B, Lubitz, SA, Bis, JC, Chung, MK, Doerr, M, Ozaki, K, Roberts, JD, Smith, JG, Pfeufer, A, Sinner, MF, Lohman, K, Ding, JZ, Smith, NL, Smith, JD, Rienstra, M, Rice, KM, Van Wagoner, DR, Magnani, JW, Wakili, R, Clauss, S, Rotter, JI, Steinbeck, G, Launer, LJ, Davies, RW, Borkovich, M, Harris, TB, Lin, HH, Volker, U, Volzke, H, Milan, DJ, Hofman, B, Boerwinkle, E, Chen, LY, Soliman, EZ, Voight, BF, Li, G, Chakravarti, A, Kubo, M, Tedrow, UB, Rose, LM, Ridker, PM, Conen, D, Tsunoda, T, Furukawa, T, Sotoodehnia, N, Xu, SY, Kamatani, N, Levy, D, Nakamura, Y, Parvez, B, Mahida, S, Furie, KL, Rosand, J, Muhammad, R, Psaty, BM, Meitinger, T, Perz, S, Wichmann, HE, Witteman, JCM, Kao, WHL, Kathiresan, S, Roden, DM, Uitterlinden, A, Rivadeneira, F, McKnight, B, Sjogren, M, Newman, AB, Liu, YM, Gollob, MH, Melander, O, Tanaka, T, Stricker, B, Felix, SB, Alonso, A, Darbar, D, Barnard, J, Chasman, DI, Heckbert, SR, Benjamin, EJ, Gudnason, V & Kaab, S 2012, 'Meta-analysis identifies six new susceptibility loci for atrial fibrillation', Nature Genetics, vol. 44, no. 6, pp. 670-U88. https://doi.org/10.1038/ng.2261

TY - JOUR

T1 - Meta-analysis identifies six new susceptibility loci for atrial fibrillation

AU - Ellinor, PT

AU - Lunetta, KL

AU - Albert, CM

AU - Glazer, NL

AU - Ritchie, MD

AU - Smith, AV

AU - Arking, DE

AU - Muller-Nurasyid, M

AU - Krijthe, Bouwe

AU - Lubitz, SA

AU - Bis, JC

AU - Chung, MK

AU - Doerr, M

AU - Ozaki, K

AU - Roberts, JD

AU - Smith, JG

AU - Pfeufer, A

AU - Sinner, MF

AU - Lohman, K

AU - Ding, JZ (Jing Zhong)

AU - Smith, NL

AU - Smith, JD

AU - Rienstra, M

AU - Rice, KM

AU - Van Wagoner, DR

AU - Magnani, JW

AU - Wakili, R

AU - Clauss, S

AU - Rotter, JI

AU - Steinbeck, G

AU - Launer, LJ (Lenore)

AU - Davies, RW

AU - Borkovich, M

AU - Harris, TB

AU - Lin, HH

AU - Volker, U

AU - Volzke, H

AU - Milan, DJ

AU - Hofman, Bert

AU - Boerwinkle, E

AU - Chen, LY

AU - Soliman, EZ

AU - Voight, BF

AU - Li, G (Guo)

AU - Chakravarti, A

AU - Kubo, M

AU - Tedrow, UB

AU - Rose, LM

AU - Ridker, PM

AU - Conen, D

AU - Tsunoda, T

AU - Furukawa, T

AU - Sotoodehnia, N

AU - Xu, SY

AU - Kamatani, N

AU - Levy, D

AU - Nakamura, Y

AU - Parvez, B

AU - Mahida, S

AU - Furie, KL

AU - Rosand, J

AU - Muhammad, R

AU - Psaty, BM

AU - Meitinger, T

AU - Perz, S

AU - Wichmann, HE

AU - Witteman, JCM

AU - Kao, WHL

AU - Kathiresan, S

AU - Roden, DM

AU - Uitterlinden, André

AU - Rivadeneira, Fernando

AU - McKnight, B

AU - Sjogren, M

AU - Newman, AB

AU - Liu, YM

AU - Gollob, MH

AU - Melander, O

AU - Tanaka, T

AU - Stricker, Bruno

AU - Felix, SB

AU - Alonso, A

AU - Darbar, D

AU - Barnard, J

AU - Chasman, DI

AU - Heckbert, SR

AU - Benjamin, EJ

AU - Gudnason, V

AU - Kaab, S

PY - 2012

Y1 - 2012

N2 - Atrial fibrillation is a highly prevalent arrhythmia and a major risk factor for stroke, heart failure and death(1). We conducted a genome-wide association study (GWAS) in individuals of European ancestry, including 6,707 with and 52,426 without atrial fibrillation. Six new atrial fibrillation susceptibility loci were identified and replicated in an additional sample of individuals of European ancestry, including 5,381 subjects with and 10,030 subjects without atrial fibrillation (P < 5 x 10(-8)). Four of the loci identified in Europeans were further replicated in silico in a GWAS of Japanese individuals, including 843 individuals with and 3,350 individuals without atrial fibrillation. The identified loci implicate candidate genes that encode transcription factors related to cardiopulmonary development, cardiac-expressed ion channels and cell signaling molecules.

AB - Atrial fibrillation is a highly prevalent arrhythmia and a major risk factor for stroke, heart failure and death(1). We conducted a genome-wide association study (GWAS) in individuals of European ancestry, including 6,707 with and 52,426 without atrial fibrillation. Six new atrial fibrillation susceptibility loci were identified and replicated in an additional sample of individuals of European ancestry, including 5,381 subjects with and 10,030 subjects without atrial fibrillation (P < 5 x 10(-8)). Four of the loci identified in Europeans were further replicated in silico in a GWAS of Japanese individuals, including 843 individuals with and 3,350 individuals without atrial fibrillation. The identified loci implicate candidate genes that encode transcription factors related to cardiopulmonary development, cardiac-expressed ion channels and cell signaling molecules.

U2 - 10.1038/ng.2261

DO - 10.1038/ng.2261

M3 - Article

C2 - 22544366

SN - 1061-4036

VL - 44

SP - 670-U88

JO - Nature Genetics

JF - Nature Genetics

IS - 6

ER -