Meta-analysis of 49 549 individuals imputed with the 1000 Genomes Project reveals an exonic damaging variant in ANGPTL4 determining fasting TG levels

Elisa Leeuwen; A Sabo; JC Bis; JE Huffman; A Manichaikul; AV Smith; MF Feitosa; S Demissie; PK Joshi; Q Duan; J Marten; JB van Klinken; I Surakka; IM Nolte; WH Zhang; H Mbarek; RF Li-Gao; S Trompet; N Verweij; E Evangelou; LP Lyytikainen; BO Tayo; J Deelen; PJ van der Most; SW van der Laan; DE Arking; A Morrison; Abbas Dehghan; OH Franco Duran; Bert Hofman; Fernando Rivadeneira; E.J.G. Sijbrands; André Uitterlinden; JC Mychaleckyj; A (Archie) Campbell; LJ Hocking; S Padmanabhan; JA Brody; KM Rice; CC White; T Harris; Aaron Isaacs; H Campbell; LA Lange; I Rudan; I Kolcic; P Navarro; T Zemunik; V Salomaa; AS Kooner; JS Kooner; B Lehne; WR Scott; ST Tan; EJ de Geus; Y Milaneschi; BWJH Penninx; G Willemsen; R de Mutsert; I Ford; RT Gansevoort; M P Segura-Lepe; OT Raitakari; JS Viikari; K Nikus; T Forrester; CA McKenzie; AJM de Craen; HM den Ruijter; G Pasterkamp; H Snieder; AJ Oldehinkel; PE (Eline) Slagboom; RS Cooper; M Kahonen; T Lehtimaki; P Elliott; P van der Harst; JW Jukema; DO Mook-Kanamori; DI Boomsma; JC Chambers; M Swertz; S Ripatti; KW van Dijk; V Vitart; O Polasek; C Hayward; JG Wilson; JF Wilson; V Gudnason; SS Rich; BM Psaty; IB Borecki; E Boerwinkle; JI Rotter; LA Cupples; Cornelia Duijn

doi:10.1136/jmedgenet-2015-103439

Meta-analysis of 49 549 individuals imputed with the 1000 Genomes Project reveals an exonic damaging variant in ANGPTL4 determining fasting TG levels

Elisa Leeuwen, A Sabo, JC Bis, JE Huffman, A Manichaikul, AV Smith, MF Feitosa, S Demissie, PK Joshi, Q Duan, J Marten, JB van Klinken, I Surakka, IM Nolte, WH Zhang, H Mbarek, RF Li-Gao, S Trompet, N Verweij, E EvangelouLP Lyytikainen, BO Tayo, J Deelen, PJ van der Most, SW van der Laan, DE Arking, A Morrison, Abbas Dehghan, OH Franco Duran, Bert Hofman, Fernando Rivadeneira, E.J.G. Sijbrands, André Uitterlinden, JC Mychaleckyj, A (Archie) Campbell, LJ Hocking, S Padmanabhan, JA Brody, KM Rice, CC White, T Harris, Aaron Isaacs, H Campbell, LA Lange, I Rudan, I Kolcic, P Navarro, T Zemunik, V Salomaa, AS Kooner, JS Kooner, B Lehne, WR Scott, ST Tan, EJ de Geus, Y Milaneschi, BWJH Penninx, G Willemsen, R de Mutsert, I Ford, RT Gansevoort, M P Segura-Lepe, OT Raitakari, JS Viikari, K Nikus, T Forrester, CA McKenzie, AJM de Craen, HM den Ruijter, G Pasterkamp, H Snieder, AJ Oldehinkel, PE (Eline) Slagboom, RS Cooper, M Kahonen, T Lehtimaki, P Elliott, P van der Harst, JW Jukema, DO Mook-Kanamori, DI Boomsma, JC Chambers, M Swertz, S Ripatti, KW van Dijk, V Vitart, O Polasek, C Hayward, JG Wilson, JF Wilson, V Gudnason, SS Rich, BM Psaty, IB Borecki, E Boerwinkle, JI Rotter, LA Cupples, Cornelia Duijn

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Original language	Undefined/Unknown
Pages (from-to)	441-449
Number of pages	9
Journal	Journal of Medical Genetics
Volume	53
Issue number	7
DOIs	https://doi.org/10.1136/jmedgenet-2015-103439
Publication status	Published - 2016

Research programs

EMC COEUR-09
EMC COEUR-09-39-01
EMC MM-01-39-09-A
EMC NIHES-01-64-02

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Cite this

Leeuwen, E., Sabo, A., Bis, JC., Huffman, JE., Manichaikul, A., Smith, AV., Feitosa, MF., Demissie, S., Joshi, PK., Duan, Q., Marten, J., van Klinken, JB., Surakka, I., Nolte, IM., Zhang, WH., Mbarek, H., Li-Gao, RF., Trompet, S., Verweij, N., ... Duijn, C. (2016). Meta-analysis of 49 549 individuals imputed with the 1000 Genomes Project reveals an exonic damaging variant in ANGPTL4 determining fasting TG levels. Journal of Medical Genetics, 53(7), 441-449. https://doi.org/10.1136/jmedgenet-2015-103439

@article{9c05324066f245b19429ffe1db988d0c,

title = "Meta-analysis of 49 549 individuals imputed with the 1000 Genomes Project reveals an exonic damaging variant in ANGPTL4 determining fasting TG levels",

author = "Elisa Leeuwen and A Sabo and JC Bis and JE Huffman and A Manichaikul and AV Smith and MF Feitosa and S Demissie and PK Joshi and Q Duan and J Marten and {van Klinken}, JB and I Surakka and IM Nolte and WH Zhang and H Mbarek and RF Li-Gao and S Trompet and N Verweij and E Evangelou and LP Lyytikainen and BO Tayo and J Deelen and {van der Most}, PJ and {van der Laan}, SW and DE Arking and A Morrison and Abbas Dehghan and {Franco Duran}, OH and Bert Hofman and Fernando Rivadeneira and E.J.G. Sijbrands and Andr{\'e} Uitterlinden and JC Mychaleckyj and Campbell, {A (Archie)} and LJ Hocking and S Padmanabhan and JA Brody and KM Rice and CC White and T Harris and Aaron Isaacs and H Campbell and LA Lange and I Rudan and I Kolcic and P Navarro and T Zemunik and V Salomaa and AS Kooner and JS Kooner and B Lehne and WR Scott and ST Tan and {de Geus}, EJ and Y Milaneschi and BWJH Penninx and G Willemsen and {de Mutsert}, R and I Ford and RT Gansevoort and Segura-Lepe, {M P} and OT Raitakari and JS Viikari and K Nikus and T Forrester and CA McKenzie and {de Craen}, AJM and {den Ruijter}, HM and G Pasterkamp and H Snieder and AJ Oldehinkel and Slagboom, {PE (Eline)} and RS Cooper and M Kahonen and T Lehtimaki and P Elliott and {van der Harst}, P and JW Jukema and DO Mook-Kanamori and DI Boomsma and JC Chambers and M Swertz and S Ripatti and {van Dijk}, KW and V Vitart and O Polasek and C Hayward and JG Wilson and JF Wilson and V Gudnason and SS Rich and BM Psaty and IB Borecki and E Boerwinkle and JI Rotter and LA Cupples and Cornelia Duijn",

year = "2016",

doi = "10.1136/jmedgenet-2015-103439",

language = "Undefined/Unknown",

volume = "53",

pages = "441--449",

journal = "Journal of Medical Genetics",

issn = "0022-2593",

publisher = "BMJ Publishing Group",

number = "7",

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Leeuwen, E, Sabo, A, Bis, JC, Huffman, JE, Manichaikul, A, Smith, AV, Feitosa, MF, Demissie, S, Joshi, PK, Duan, Q, Marten, J, van Klinken, JB, Surakka, I, Nolte, IM, Zhang, WH, Mbarek, H, Li-Gao, RF, Trompet, S, Verweij, N, Evangelou, E, Lyytikainen, LP, Tayo, BO, Deelen, J, van der Most, PJ, van der Laan, SW, Arking, DE, Morrison, A, Dehghan, A, Franco Duran, OH, Hofman, B , Rivadeneira, F , Sijbrands, EJG , Uitterlinden, A, Mychaleckyj, JC, Campbell, A, Hocking, LJ, Padmanabhan, S, Brody, JA, Rice, KM, White, CC, Harris, T, Isaacs, A, Campbell, H, Lange, LA, Rudan, I, Kolcic, I, Navarro, P, Zemunik, T, Salomaa, V, Kooner, AS, Kooner, JS, Lehne, B, Scott, WR, Tan, ST, de Geus, EJ, Milaneschi, Y, Penninx, BWJH, Willemsen, G, de Mutsert, R, Ford, I, Gansevoort, RT, Segura-Lepe, MP, Raitakari, OT, Viikari, JS, Nikus, K, Forrester, T, McKenzie, CA, de Craen, AJM, den Ruijter, HM, Pasterkamp, G, Snieder, H, Oldehinkel, AJ, Slagboom, PE, Cooper, RS, Kahonen, M, Lehtimaki, T, Elliott, P, van der Harst, P, Jukema, JW, Mook-Kanamori, DO, Boomsma, DI, Chambers, JC, Swertz, M, Ripatti, S, van Dijk, KW, Vitart, V, Polasek, O, Hayward, C, Wilson, JG, Wilson, JF, Gudnason, V, Rich, SS, Psaty, BM, Borecki, IB, Boerwinkle, E, Rotter, JI, Cupples, LA & Duijn, C 2016, 'Meta-analysis of 49 549 individuals imputed with the 1000 Genomes Project reveals an exonic damaging variant in ANGPTL4 determining fasting TG levels', Journal of Medical Genetics, vol. 53, no. 7, pp. 441-449. https://doi.org/10.1136/jmedgenet-2015-103439

TY - JOUR

T1 - Meta-analysis of 49 549 individuals imputed with the 1000 Genomes Project reveals an exonic damaging variant in ANGPTL4 determining fasting TG levels

AU - Leeuwen, Elisa

AU - Sabo, A

AU - Bis, JC

AU - Huffman, JE

AU - Manichaikul, A

AU - Smith, AV

AU - Feitosa, MF

AU - Demissie, S

AU - Joshi, PK

AU - Duan, Q

AU - Marten, J

AU - van Klinken, JB

AU - Surakka, I

AU - Nolte, IM

AU - Zhang, WH

AU - Mbarek, H

AU - Li-Gao, RF

AU - Trompet, S

AU - Verweij, N

AU - Evangelou, E

AU - Lyytikainen, LP

AU - Tayo, BO

AU - Deelen, J

AU - van der Most, PJ

AU - van der Laan, SW

AU - Arking, DE

AU - Morrison, A

AU - Dehghan, Abbas

AU - Franco Duran, OH

AU - Hofman, Bert

AU - Rivadeneira, Fernando

AU - Sijbrands, E.J.G.

AU - Uitterlinden, André

AU - Mychaleckyj, JC

AU - Campbell, A (Archie)

AU - Hocking, LJ

AU - Padmanabhan, S

AU - Brody, JA

AU - Rice, KM

AU - White, CC

AU - Harris, T

AU - Isaacs, Aaron

AU - Campbell, H

AU - Lange, LA

AU - Rudan, I

AU - Kolcic, I

AU - Navarro, P

AU - Zemunik, T

AU - Salomaa, V

AU - Kooner, AS

AU - Kooner, JS

AU - Lehne, B

AU - Scott, WR

AU - Tan, ST

AU - de Geus, EJ

AU - Milaneschi, Y

AU - Penninx, BWJH

AU - Willemsen, G

AU - de Mutsert, R

AU - Ford, I

AU - Gansevoort, RT

AU - Segura-Lepe, M P

AU - Raitakari, OT

AU - Viikari, JS

AU - Nikus, K

AU - Forrester, T

AU - McKenzie, CA

AU - de Craen, AJM

AU - den Ruijter, HM

AU - Pasterkamp, G

AU - Snieder, H

AU - Oldehinkel, AJ

AU - Slagboom, PE (Eline)

AU - Cooper, RS

AU - Kahonen, M

AU - Lehtimaki, T

AU - Elliott, P

AU - van der Harst, P

AU - Jukema, JW

AU - Mook-Kanamori, DO

AU - Boomsma, DI

AU - Chambers, JC

AU - Swertz, M

AU - Ripatti, S

AU - van Dijk, KW

AU - Vitart, V

AU - Polasek, O

AU - Hayward, C

AU - Wilson, JG

AU - Wilson, JF

AU - Gudnason, V

AU - Rich, SS

AU - Psaty, BM

AU - Borecki, IB

AU - Boerwinkle, E

AU - Rotter, JI

AU - Cupples, LA

AU - Duijn, Cornelia

PY - 2016

Y1 - 2016

U2 - 10.1136/jmedgenet-2015-103439

DO - 10.1136/jmedgenet-2015-103439

M3 - Article

C2 - 27036123

SN - 0022-2593

VL - 53

SP - 441

EP - 449

JO - Journal of Medical Genetics

JF - Journal of Medical Genetics

IS - 7

ER -