Meta-analysis of gene-environment-wide association scans accounting for education level identifies additional loci for refractive error

Q Fan; Virginie Verhoeven; R Wojciechowski; VA Barathi; PG Hysi; JA Guggenheim; R Hohn; V Vitart; AP Khawaja; K Yamashiro; SM Hosseini; T Lehtimaki; Y (Yi) Lu; T Haller; J Xie; C Delcourt; M Pirastu; J Wedenoja; P Gharahkhani; C Venturini; M Miyake; AW Hewitt; XB Guo; J Mazur; JE Huffman; KM Williams; O Polasek; H Campbell; I Rudan; Z Vatavuk; JF Wilson; PK Joshi; G McMahon; B St Pourcain; DM Evans; CL Simpson; TH Schwantes-An; RP Igo; A Mirshahi; A Cougnard-Gregoire; C Bellenguez; M Blettner; O Raitakari; M Kaehoenen; I Seppala; T Zeller; T Meitinger; JS Ried; C Gieger; L Portas; Elisa Leeuwen; Najaf Amin; André Uitterlinden; Fernando Rivadeneira; Bert Hofman; Hans Vingerling; YX Wang; X Wang; ETH Boh; Kamran Ikram; C Sabanayagam; P Gupta; V Tan; L Zhou; CEH Ho; W Lim; RW Beuerman; R Siantar; ES Tai; E Vithana; E Mihailov; CC Khor; C Hayward; RN Luben; PJ Foster; BEK Klein; R Klein; HS Wong; P Mitchell; A Metspalu; T Aung; TL Young; MG He; O Paerssinen; Cornelia Duijn; JJ Wang; C Williams; JB Jonas; YY Teo; AMM David; K Oexle; N Yoshimura; AD Paterson; N Pfeiffer; TY (Tien Yin) Wong; PN Baird; D Stambolian; JE Bailey-Wilson; CY (Ching-Yu) Cheng; CJ Hammond; Caroline Klaver; SM Saw; JS Rahi; JF Korobelnik; JP Kemp; NJ Timpson; GD Smith; JE Craig; KP Burdon; RD Fogarty; SK Iyengar; E Chew; S Janmahasatian; NG Martin; S Macgregor; L Xu; M Schache; V Nangia; S Panda-Jonas; AF Wright; JR Fondran; JH Lass; S Feng; JH Zhao; KT Khaw; NJ Wareham; T Rantanen; J Kaprio; CP Pang; LJ Chen; PO Tam; V Jhanji; AL Young; A Doering; LJ Raffel; MF Cotch; XH Li; SP Yip; MKH Yap; G Biino; S Vaccargiu; M Fossarello; B Fleck; S Yazar; Willem Tideman; M Tedja; MM DeAngelis; M Morrison; L Farrer; XT Zhou; W Chen; N Mizuki; A Meguro; KM Makela

doi:10.1038/ncomms11008

Meta-analysis of gene-environment-wide association scans accounting for education level identifies additional loci for refractive error

Q Fan, Virginie Verhoeven, R Wojciechowski, VA Barathi, PG Hysi, JA Guggenheim, R Hohn, V Vitart, AP Khawaja, K Yamashiro, SM Hosseini, T Lehtimaki, Y (Yi) Lu, T Haller, J Xie, C Delcourt, M Pirastu, J Wedenoja, P Gharahkhani, C VenturiniM Miyake, AW Hewitt, XB Guo, J Mazur, JE Huffman, KM Williams, O Polasek, H Campbell, I Rudan, Z Vatavuk, JF Wilson, PK Joshi, G McMahon, B St Pourcain, DM Evans, CL Simpson, TH Schwantes-An, RP Igo, A Mirshahi, A Cougnard-Gregoire, C Bellenguez, M Blettner, O Raitakari, M Kaehoenen, I Seppala, T Zeller, T Meitinger, JS Ried, C Gieger, L Portas, Elisa Leeuwen, Najaf Amin, André Uitterlinden, Fernando Rivadeneira, Bert Hofman, Hans Vingerling, YX Wang, X Wang, ETH Boh, Kamran Ikram, C Sabanayagam, P Gupta, V Tan, L Zhou, CEH Ho, W Lim, RW Beuerman, R Siantar, ES Tai, E Vithana, E Mihailov, CC Khor, C Hayward, RN Luben, PJ Foster, BEK Klein, R Klein, HS Wong, P Mitchell, A Metspalu, T Aung, TL Young, MG He, O Paerssinen, Cornelia Duijn, JJ Wang, C Williams, JB Jonas, YY Teo, AMM David, K Oexle, N Yoshimura, AD Paterson, N Pfeiffer, TY (Tien Yin) Wong, PN Baird, D Stambolian, JE Bailey-Wilson, CY (Ching-Yu) Cheng, CJ Hammond, Caroline Klaver, SM Saw, JS Rahi, JF Korobelnik, JP Kemp, NJ Timpson, GD Smith, JE Craig, KP Burdon, RD Fogarty, SK Iyengar, E Chew, S Janmahasatian, NG Martin, S Macgregor, L Xu, M Schache, V Nangia, S Panda-Jonas, AF Wright, JR Fondran, JH Lass, S Feng, JH Zhao, KT Khaw, NJ Wareham, T Rantanen, J Kaprio, CP Pang, LJ Chen, PO Tam, V Jhanji, AL Young, A Doering, LJ Raffel, MF Cotch, XH Li, SP Yip, MKH Yap, G Biino, S Vaccargiu, M Fossarello, B Fleck, S Yazar, Willem Tideman, M Tedja, MM DeAngelis, M Morrison, L Farrer, XT Zhou, W Chen, N Mizuki, A Meguro, KM Makela

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Abstract

Myopia is the most common human eye disorder and it results from complex genetic and environmental causes. The rapidly increasing prevalence of myopia poses a major public health challenge. Here, the CREAM consortium performs a joint meta-analysis to test single-nucleotide polymorphism (SNP) main effects and SNP x education interaction effects on refractive error in 40,036 adults from 25 studies of European ancestry and 10,315 adults from 9 studies of Asian ancestry. In European ancestry individuals, we identify six novel loci (FAM150B-ACP1, LINC00340, FBN1, DIS3L-MAP2K1, ARID2-SNAT1 and SLC14A2) associated with refractive error. In Asian populations, three genome-wide significant loci AREG, GABRR1 and PDE10A also exhibit strong interactions with education (P < 8.5 x 10(-5)), whereas the interactions are less evident in Europeans. The discovery of these loci represents an important advance in understanding how gene and environment interactions contribute to the heterogeneity of myopia.

Original language	Undefined/Unknown
Journal	Nature Communications
Volume	7
DOIs	https://doi.org/10.1038/ncomms11008
Publication status	Published - 2016

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EMC MM-01-39-09-A
EMC NIHES-01-64-01
EMC OR-01-60-01

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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Cite this

Fan, Q., Verhoeven, V., Wojciechowski, R., Barathi, VA., Hysi, PG., Guggenheim, JA., Hohn, R., Vitart, V., Khawaja, AP., Yamashiro, K., Hosseini, SM., Lehtimaki, T., Lu, Y., Haller, T., Xie, J., Delcourt, C., Pirastu, M., Wedenoja, J., Gharahkhani, P., ... Makela, KM. (2016). Meta-analysis of gene-environment-wide association scans accounting for education level identifies additional loci for refractive error. Nature Communications, 7. https://doi.org/10.1038/ncomms11008

@article{f4c7aeec4dcb4fb7bc9123fd03dcf8a7,

title = "Meta-analysis of gene-environment-wide association scans accounting for education level identifies additional loci for refractive error",

abstract = "Myopia is the most common human eye disorder and it results from complex genetic and environmental causes. The rapidly increasing prevalence of myopia poses a major public health challenge. Here, the CREAM consortium performs a joint meta-analysis to test single-nucleotide polymorphism (SNP) main effects and SNP x education interaction effects on refractive error in 40,036 adults from 25 studies of European ancestry and 10,315 adults from 9 studies of Asian ancestry. In European ancestry individuals, we identify six novel loci (FAM150B-ACP1, LINC00340, FBN1, DIS3L-MAP2K1, ARID2-SNAT1 and SLC14A2) associated with refractive error. In Asian populations, three genome-wide significant loci AREG, GABRR1 and PDE10A also exhibit strong interactions with education (P < 8.5 x 10(-5)), whereas the interactions are less evident in Europeans. The discovery of these loci represents an important advance in understanding how gene and environment interactions contribute to the heterogeneity of myopia.",

author = "Q Fan and Virginie Verhoeven and R Wojciechowski and VA Barathi and PG Hysi and JA Guggenheim and R Hohn and V Vitart and AP Khawaja and K Yamashiro and SM Hosseini and T Lehtimaki and Lu, {Y (Yi)} and T Haller and J Xie and C Delcourt and M Pirastu and J Wedenoja and P Gharahkhani and C Venturini and M Miyake and AW Hewitt and XB Guo and J Mazur and JE Huffman and KM Williams and O Polasek and H Campbell and I Rudan and Z Vatavuk and JF Wilson and PK Joshi and G McMahon and {St Pourcain}, B and DM Evans and CL Simpson and TH Schwantes-An and RP Igo and A Mirshahi and A Cougnard-Gregoire and C Bellenguez and M Blettner and O Raitakari and M Kaehoenen and I Seppala and T Zeller and T Meitinger and JS Ried and C Gieger and L Portas and Elisa Leeuwen and Najaf Amin and Andr{\'e} Uitterlinden and Fernando Rivadeneira and Bert Hofman and Hans Vingerling and YX Wang and X Wang and ETH Boh and Kamran Ikram and C Sabanayagam and P Gupta and V Tan and L Zhou and CEH Ho and W Lim and RW Beuerman and R Siantar and ES Tai and E Vithana and E Mihailov and CC Khor and C Hayward and RN Luben and PJ Foster and BEK Klein and R Klein and HS Wong and P Mitchell and A Metspalu and T Aung and TL Young and MG He and O Paerssinen and Cornelia Duijn and JJ Wang and C Williams and JB Jonas and YY Teo and AMM David and K Oexle and N Yoshimura and AD Paterson and N Pfeiffer and Wong, {TY (Tien Yin)} and PN Baird and D Stambolian and JE Bailey-Wilson and Cheng, {CY (Ching-Yu)} and CJ Hammond and Caroline Klaver and SM Saw and JS Rahi and JF Korobelnik and JP Kemp and NJ Timpson and GD Smith and JE Craig and KP Burdon and RD Fogarty and SK Iyengar and E Chew and S Janmahasatian and NG Martin and S Macgregor and L Xu and M Schache and V Nangia and S Panda-Jonas and AF Wright and JR Fondran and JH Lass and S Feng and JH Zhao and KT Khaw and NJ Wareham and T Rantanen and J Kaprio and CP Pang and LJ Chen and PO Tam and V Jhanji and AL Young and A Doering and LJ Raffel and MF Cotch and XH Li and SP Yip and MKH Yap and G Biino and S Vaccargiu and M Fossarello and B Fleck and S Yazar and Willem Tideman and M Tedja and MM DeAngelis and M Morrison and L Farrer and XT Zhou and W Chen and N Mizuki and A Meguro and KM Makela",

year = "2016",

doi = "10.1038/ncomms11008",

language = "Undefined/Unknown",

volume = "7",

journal = "Nature Communications",

issn = "2041-1723",

publisher = "Nature Publishing Group",

}

Fan, Q, Verhoeven, V, Wojciechowski, R, Barathi, VA, Hysi, PG, Guggenheim, JA, Hohn, R, Vitart, V, Khawaja, AP, Yamashiro, K, Hosseini, SM, Lehtimaki, T, Lu, Y, Haller, T, Xie, J, Delcourt, C, Pirastu, M, Wedenoja, J, Gharahkhani, P, Venturini, C, Miyake, M, Hewitt, AW, Guo, XB, Mazur, J, Huffman, JE, Williams, KM, Polasek, O, Campbell, H, Rudan, I, Vatavuk, Z, Wilson, JF, Joshi, PK, McMahon, G, St Pourcain, B, Evans, DM, Simpson, CL, Schwantes-An, TH, Igo, RP, Mirshahi, A, Cougnard-Gregoire, A, Bellenguez, C, Blettner, M, Raitakari, O, Kaehoenen, M, Seppala, I, Zeller, T, Meitinger, T, Ried, JS, Gieger, C, Portas, L, Leeuwen, E, Amin, N , Uitterlinden, A , Rivadeneira, F , Hofman, B , Vingerling, H, Wang, YX, Wang, X, Boh, ETH, Ikram, K, Sabanayagam, C, Gupta, P, Tan, V, Zhou, L, Ho, CEH, Lim, W, Beuerman, RW, Siantar, R, Tai, ES, Vithana, E, Mihailov, E, Khor, CC, Hayward, C, Luben, RN, Foster, PJ, Klein, BEK, Klein, R, Wong, HS, Mitchell, P, Metspalu, A, Aung, T, Young, TL, He, MG, Paerssinen, O, Duijn, C, Wang, JJ, Williams, C, Jonas, JB, Teo, YY, David, AMM, Oexle, K, Yoshimura, N, Paterson, AD, Pfeiffer, N, Wong, TY, Baird, PN, Stambolian, D, Bailey-Wilson, JE, Cheng, CY, Hammond, CJ, Klaver, C, Saw, SM, Rahi, JS, Korobelnik, JF, Kemp, JP, Timpson, NJ, Smith, GD, Craig, JE, Burdon, KP, Fogarty, RD, Iyengar, SK, Chew, E, Janmahasatian, S, Martin, NG, Macgregor, S, Xu, L, Schache, M, Nangia, V, Panda-Jonas, S, Wright, AF, Fondran, JR, Lass, JH, Feng, S, Zhao, JH, Khaw, KT, Wareham, NJ, Rantanen, T, Kaprio, J, Pang, CP, Chen, LJ, Tam, PO, Jhanji, V, Young, AL, Doering, A, Raffel, LJ, Cotch, MF, Li, XH, Yip, SP, Yap, MKH, Biino, G, Vaccargiu, S, Fossarello, M, Fleck, B, Yazar, S, Tideman, W, Tedja, M, DeAngelis, MM, Morrison, M, Farrer, L, Zhou, XT, Chen, W, Mizuki, N, Meguro, A & Makela, KM 2016, 'Meta-analysis of gene-environment-wide association scans accounting for education level identifies additional loci for refractive error', Nature Communications, vol. 7. https://doi.org/10.1038/ncomms11008

TY - JOUR

T1 - Meta-analysis of gene-environment-wide association scans accounting for education level identifies additional loci for refractive error

AU - Fan, Q

AU - Verhoeven, Virginie

AU - Wojciechowski, R

AU - Barathi, VA

AU - Hysi, PG

AU - Guggenheim, JA

AU - Hohn, R

AU - Vitart, V

AU - Khawaja, AP

AU - Yamashiro, K

AU - Hosseini, SM

AU - Lehtimaki, T

AU - Lu, Y (Yi)

AU - Haller, T

AU - Xie, J

AU - Delcourt, C

AU - Pirastu, M

AU - Wedenoja, J

AU - Gharahkhani, P

AU - Venturini, C

AU - Miyake, M

AU - Hewitt, AW

AU - Guo, XB

AU - Mazur, J

AU - Huffman, JE

AU - Williams, KM

AU - Polasek, O

AU - Campbell, H

AU - Rudan, I

AU - Vatavuk, Z

AU - Wilson, JF

AU - Joshi, PK

AU - McMahon, G

AU - St Pourcain, B

AU - Evans, DM

AU - Simpson, CL

AU - Schwantes-An, TH

AU - Igo, RP

AU - Mirshahi, A

AU - Cougnard-Gregoire, A

AU - Bellenguez, C

AU - Blettner, M

AU - Raitakari, O

AU - Kaehoenen, M

AU - Seppala, I

AU - Zeller, T

AU - Meitinger, T

AU - Ried, JS

AU - Gieger, C

AU - Portas, L

AU - Leeuwen, Elisa

AU - Amin, Najaf

AU - Uitterlinden, André

AU - Rivadeneira, Fernando

AU - Hofman, Bert

AU - Vingerling, Hans

AU - Wang, YX

AU - Wang, X

AU - Boh, ETH

AU - Ikram, Kamran

AU - Sabanayagam, C

AU - Gupta, P

AU - Tan, V

AU - Zhou, L

AU - Ho, CEH

AU - Lim, W

AU - Beuerman, RW

AU - Siantar, R

AU - Tai, ES

AU - Vithana, E

AU - Mihailov, E

AU - Khor, CC

AU - Hayward, C

AU - Luben, RN

AU - Foster, PJ

AU - Klein, BEK

AU - Klein, R

AU - Wong, HS

AU - Mitchell, P

AU - Metspalu, A

AU - Aung, T

AU - Young, TL

AU - He, MG

AU - Paerssinen, O

AU - Duijn, Cornelia

AU - Wang, JJ

AU - Williams, C

AU - Jonas, JB

AU - Teo, YY

AU - David, AMM

AU - Oexle, K

AU - Yoshimura, N

AU - Paterson, AD

AU - Pfeiffer, N

AU - Wong, TY (Tien Yin)

AU - Baird, PN

AU - Stambolian, D

AU - Bailey-Wilson, JE

AU - Cheng, CY (Ching-Yu)

AU - Hammond, CJ

AU - Klaver, Caroline

AU - Saw, SM

AU - Rahi, JS

AU - Korobelnik, JF

AU - Kemp, JP

AU - Timpson, NJ

AU - Smith, GD

AU - Craig, JE

AU - Burdon, KP

AU - Fogarty, RD

AU - Iyengar, SK

AU - Chew, E

AU - Janmahasatian, S

AU - Martin, NG

AU - Macgregor, S

AU - Xu, L

AU - Schache, M

AU - Nangia, V

AU - Panda-Jonas, S

AU - Wright, AF

AU - Fondran, JR

AU - Lass, JH

AU - Feng, S

AU - Zhao, JH

AU - Khaw, KT

AU - Wareham, NJ

AU - Rantanen, T

AU - Kaprio, J

AU - Pang, CP

AU - Chen, LJ

AU - Tam, PO

AU - Jhanji, V

AU - Young, AL

AU - Doering, A

AU - Raffel, LJ

AU - Cotch, MF

AU - Li, XH

AU - Yip, SP

AU - Yap, MKH

AU - Biino, G

AU - Vaccargiu, S

AU - Fossarello, M

AU - Fleck, B

AU - Yazar, S

AU - Tideman, Willem

AU - Tedja, M

AU - DeAngelis, MM

AU - Morrison, M

AU - Farrer, L

AU - Zhou, XT

AU - Chen, W

AU - Mizuki, N

AU - Meguro, A

AU - Makela, KM

PY - 2016

Y1 - 2016

N2 - Myopia is the most common human eye disorder and it results from complex genetic and environmental causes. The rapidly increasing prevalence of myopia poses a major public health challenge. Here, the CREAM consortium performs a joint meta-analysis to test single-nucleotide polymorphism (SNP) main effects and SNP x education interaction effects on refractive error in 40,036 adults from 25 studies of European ancestry and 10,315 adults from 9 studies of Asian ancestry. In European ancestry individuals, we identify six novel loci (FAM150B-ACP1, LINC00340, FBN1, DIS3L-MAP2K1, ARID2-SNAT1 and SLC14A2) associated with refractive error. In Asian populations, three genome-wide significant loci AREG, GABRR1 and PDE10A also exhibit strong interactions with education (P < 8.5 x 10(-5)), whereas the interactions are less evident in Europeans. The discovery of these loci represents an important advance in understanding how gene and environment interactions contribute to the heterogeneity of myopia.

AB - Myopia is the most common human eye disorder and it results from complex genetic and environmental causes. The rapidly increasing prevalence of myopia poses a major public health challenge. Here, the CREAM consortium performs a joint meta-analysis to test single-nucleotide polymorphism (SNP) main effects and SNP x education interaction effects on refractive error in 40,036 adults from 25 studies of European ancestry and 10,315 adults from 9 studies of Asian ancestry. In European ancestry individuals, we identify six novel loci (FAM150B-ACP1, LINC00340, FBN1, DIS3L-MAP2K1, ARID2-SNAT1 and SLC14A2) associated with refractive error. In Asian populations, three genome-wide significant loci AREG, GABRR1 and PDE10A also exhibit strong interactions with education (P < 8.5 x 10(-5)), whereas the interactions are less evident in Europeans. The discovery of these loci represents an important advance in understanding how gene and environment interactions contribute to the heterogeneity of myopia.

U2 - 10.1038/ncomms11008

DO - 10.1038/ncomms11008

M3 - Article

C2 - 27020472

SN - 2041-1723

VL - 7

JO - Nature Communications

JF - Nature Communications

ER -