Meta-analysis of genome-wide association data identifies two loci influencing age at menarche

JRB Perry, Lisette Stolk, N Franceschini, KL Lunetta, GJ Zhai, PF McArdle, AV Smith, T Aspelund, S Bandinelli, E Boerwinkle, L Cherkas, G Eiriksdottir, Karol Estrada Gil, L Ferrucci, AR Folsom, M Garcia, V Gudnason, Bert Hofman, D Karasik, DP KielLJ (Lenore) Launer, Joyce van Meurs, MA Nalls, Fernando Rivadeneira, AR Shuldiner, A Singleton, N Soranzo, T Tanaka, Jenny Visser, MN Weedon, SG Wilson, V Zhuang, EA Streeten, TB Harris, A Murray, TD Spector, EW Demerath, André Uitterlinden, JM Murabito

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Abstract

We conducted a meta-analysis of genome-wide association data to detect genes influencing age at menarche in 17,510 women. The strongest signal was at 9q31.2 (P = 1.7 x 10(-9)), where the nearest genes include TMEM38B, FKTN, FSD1L, TAL2 and ZNF462. The next best signal was near the LIN28B gene (rs7759938; P = 7.0 x 10(-9)), which also influences adult height. We provide the first evidence for common genetic variants influencing female sexual maturation.
Original languageUndefined/Unknown
Pages (from-to)648-650
Number of pages3
JournalNature Genetics
Volume41
Issue number6
DOIs
Publication statusPublished - 2009

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