Meta-analysis of genome-wide association data identifies two loci influencing age at menarche

JRB Perry; Lisette Stolk; N Franceschini; KL Lunetta; GJ Zhai; PF McArdle; AV Smith; T Aspelund; S Bandinelli; E Boerwinkle; L Cherkas; G Eiriksdottir; Karol Estrada Gil; L Ferrucci; AR Folsom; M Garcia; V Gudnason; Bert Hofman; D Karasik; DP Kiel; LJ (Lenore) Launer; Joyce van Meurs; MA Nalls; Fernando Rivadeneira; AR Shuldiner; A Singleton; N Soranzo; T Tanaka; Jenny Visser; MN Weedon; SG Wilson; V Zhuang; EA Streeten; TB Harris; A Murray; TD Spector; EW Demerath; André Uitterlinden; JM Murabito

doi:10.1038/ng.386

Meta-analysis of genome-wide association data identifies two loci influencing age at menarche

JRB Perry
, Lisette Stolk
, N Franceschini
, KL Lunetta
, GJ Zhai
, PF McArdle
, AV Smith
, T Aspelund
, S Bandinelli
, E Boerwinkle
, L Cherkas
, G Eiriksdottir
, Karol Estrada Gil
, L Ferrucci
, AR Folsom
, M Garcia
, V Gudnason
, Bert Hofman
, D Karasik
, DP Kiel

LJ (Lenore) Launer, Joyce van Meurs, MA Nalls, Fernando Rivadeneira, AR Shuldiner, A Singleton, N Soranzo, T Tanaka, Jenny Visser, MN Weedon, SG Wilson, V Zhuang, EA Streeten, TB Harris, A Murray, TD Spector, EW Demerath, André Uitterlinden, JM Murabito

External organisation

Research output: Contribution to journal › Article › Academic › peer-review

256 Citations (Scopus)

Abstract

We conducted a meta-analysis of genome-wide association data to detect genes influencing age at menarche in 17,510 women. The strongest signal was at 9q31.2 (P = 1.7 x 10(-9)), where the nearest genes include TMEM38B, FKTN, FSD1L, TAL2 and ZNF462. The next best signal was near the LIN28B gene (rs7759938; P = 7.0 x 10(-9)), which also influences adult height. We provide the first evidence for common genetic variants influencing female sexual maturation.

Original language	Undefined/Unknown
Pages (from-to)	648-650
Number of pages	3
Journal	Nature Genetics
Volume	41
Issue number	6
DOIs	https://doi.org/10.1038/ng.386
Publication status	Published - 2009

Research programs

EMC MM-01-39-04

Access to Document

10.1038/ng.386

http://hdl.handle.net/1765/24578

Cite this

Perry, JRB., Stolk, L., Franceschini, N., Lunetta, KL., Zhai, GJ., McArdle, PF., Smith, AV., Aspelund, T., Bandinelli, S., Boerwinkle, E., Cherkas, L., Eiriksdottir, G., Estrada Gil, K., Ferrucci, L., Folsom, AR., Garcia, M., Gudnason, V., Hofman, B., Karasik, D., ... Murabito, JM. (2009). Meta-analysis of genome-wide association data identifies two loci influencing age at menarche. Nature Genetics, 41(6), 648-650. https://doi.org/10.1038/ng.386

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title = "Meta-analysis of genome-wide association data identifies two loci influencing age at menarche",

abstract = "We conducted a meta-analysis of genome-wide association data to detect genes influencing age at menarche in 17,510 women. The strongest signal was at 9q31.2 (P = 1.7 x 10(-9)), where the nearest genes include TMEM38B, FKTN, FSD1L, TAL2 and ZNF462. The next best signal was near the LIN28B gene (rs7759938; P = 7.0 x 10(-9)), which also influences adult height. We provide the first evidence for common genetic variants influencing female sexual maturation.",

author = "JRB Perry and Lisette Stolk and N Franceschini and KL Lunetta and GJ Zhai and PF McArdle and AV Smith and T Aspelund and S Bandinelli and E Boerwinkle and L Cherkas and G Eiriksdottir and \{Estrada Gil\}, Karol and L Ferrucci and AR Folsom and M Garcia and V Gudnason and Bert Hofman and D Karasik and DP Kiel and Launer, \{LJ (Lenore)\} and \{van Meurs\}, Joyce and MA Nalls and Fernando Rivadeneira and AR Shuldiner and A Singleton and N Soranzo and T Tanaka and Jenny Visser and MN Weedon and SG Wilson and V Zhuang and EA Streeten and TB Harris and A Murray and TD Spector and EW Demerath and Andr{\'e} Uitterlinden and JM Murabito",

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doi = "10.1038/ng.386",

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Perry, JRB, Stolk, L, Franceschini, N, Lunetta, KL, Zhai, GJ, McArdle, PF, Smith, AV, Aspelund, T, Bandinelli, S, Boerwinkle, E, Cherkas, L, Eiriksdottir, G, Estrada Gil, K, Ferrucci, L, Folsom, AR, Garcia, M, Gudnason, V, Hofman, B, Karasik, D, Kiel, DP, Launer, LJ, van Meurs, J, Nalls, MA, Rivadeneira, F, Shuldiner, AR, Singleton, A, Soranzo, N, Tanaka, T, Visser, J, Weedon, MN, Wilson, SG, Zhuang, V, Streeten, EA, Harris, TB, Murray, A, Spector, TD, Demerath, EW, Uitterlinden, A & Murabito, JM 2009, 'Meta-analysis of genome-wide association data identifies two loci influencing age at menarche', Nature Genetics, vol. 41, no. 6, pp. 648-650. https://doi.org/10.1038/ng.386

TY - JOUR

T1 - Meta-analysis of genome-wide association data identifies two loci influencing age at menarche

AU - Perry, JRB

AU - Stolk, Lisette

AU - Franceschini, N

AU - Lunetta, KL

AU - Zhai, GJ

AU - McArdle, PF

AU - Smith, AV

AU - Aspelund, T

AU - Bandinelli, S

AU - Boerwinkle, E

AU - Cherkas, L

AU - Eiriksdottir, G

AU - Estrada Gil, Karol

AU - Ferrucci, L

AU - Folsom, AR

AU - Garcia, M

AU - Gudnason, V

AU - Hofman, Bert

AU - Karasik, D

AU - Kiel, DP

AU - Launer, LJ (Lenore)

AU - van Meurs, Joyce

AU - Nalls, MA

AU - Rivadeneira, Fernando

AU - Shuldiner, AR

AU - Singleton, A

AU - Soranzo, N

AU - Tanaka, T

AU - Visser, Jenny

AU - Weedon, MN

AU - Wilson, SG

AU - Zhuang, V

AU - Streeten, EA

AU - Harris, TB

AU - Murray, A

AU - Spector, TD

AU - Demerath, EW

AU - Uitterlinden, André

AU - Murabito, JM

PY - 2009

Y1 - 2009

N2 - We conducted a meta-analysis of genome-wide association data to detect genes influencing age at menarche in 17,510 women. The strongest signal was at 9q31.2 (P = 1.7 x 10(-9)), where the nearest genes include TMEM38B, FKTN, FSD1L, TAL2 and ZNF462. The next best signal was near the LIN28B gene (rs7759938; P = 7.0 x 10(-9)), which also influences adult height. We provide the first evidence for common genetic variants influencing female sexual maturation.

AB - We conducted a meta-analysis of genome-wide association data to detect genes influencing age at menarche in 17,510 women. The strongest signal was at 9q31.2 (P = 1.7 x 10(-9)), where the nearest genes include TMEM38B, FKTN, FSD1L, TAL2 and ZNF462. The next best signal was near the LIN28B gene (rs7759938; P = 7.0 x 10(-9)), which also influences adult height. We provide the first evidence for common genetic variants influencing female sexual maturation.

U2 - 10.1038/ng.386

DO - 10.1038/ng.386

M3 - Article

C2 - 19448620

SN - 1061-4036

VL - 41

SP - 648

EP - 650

JO - Nature Genetics

JF - Nature Genetics

IS - 6

ER -