Meta-analytic Review of Memory Impairment in Behavioral Variant Frontotemporal Dementia

Research output: Contribution to journalArticleAcademicpeer-review

28 Citations (Scopus)
37 Downloads (Pure)


Objectives: A meta-analysis of the extent, nature and pattern of memory performance in behavioral variant frontotemporal dementia (bvFTD). Multiple observational studies have challenged the relative sparing of memory in bvFTD as stated in the current diagnostic criteria. Methods: We performed a meta-analytic review covering the period 1967 to February 2017 of case-control studies on episodic memory in bvFTD versus control participants (16 studies, 383 patients, 603 control participants), and patients with bvFTD versus those with Alzheimer's disease (AD) (20 studies, 452 bvFTD, 874 AD). Differences between both verbal and non-verbal working memory, episodic memory learning and recall, and recognition memory were examined. Data were extracted from the papers and combined into a common metric measure of effect, Hedges' d. Results: Patients with bvFTD show large deficits in memory performance compared to controls (Hedges' d -1.10; 95% confidence interval [CI] [-1.23, -0.95]), but perform significantly better than patients with AD (Hedges' d 0.85; 95% CI [0.69, 1.03]). Learning and recall tests differentiate best between patients with bvFTD and AD (p < .01). There is 37-62% overlap in test scores between the two groups. Conclusions: This study points to memory disorders in patients with bvFTD, with performance at an intermediate level between controls and patients with AD. This indicates that, instead of being an exclusion criterion for bvFTD diagnosis, memory deficits should be regarded as a potential integral part of the clinical spectrum.

Original languageEnglish
Pages (from-to)593-605
Number of pages13
JournalJournal of the International Neuropsychological Society
Issue number6
Publication statusPublished - 19 Mar 2018

Research programs

  • EMC OR-01


Dive into the research topics of 'Meta-analytic Review of Memory Impairment in Behavioral Variant Frontotemporal Dementia'. Together they form a unique fingerprint.

Cite this