Metabolic Gene Polymorphism Frequencies in Control Populations

Seymour Garte*, Laura Gaspari, Anna-Karin Alexandrie, Christine B. Ambrosone, Herman Autrup, Judith L. Autrup, Helena Baranova, Lise Bathum, Simone Benhamou, Paolo Boffetta, Christine Bouchardy, Katja Breskvar, Jurgen Brockmoller, Ingolf Cascorbi, Margie L. Clapper, Christiane Coutelle, Anne Daly, Marco Dell'Omo, Vita Dolžan, Carolyn M. DreslerAnthony Fryer, Aage Haugen, David W. Hein, Allan Hildesheim, Ari Hirvonen, Ling-Ling Hsieh, Magnus Ingelman-Sundberg, Ivan Kalina , Daehee Kang, Masahiro Kihara, Chikako Kiyohara, Pierre Kremers, Philip Lazarus, Loic Le Marchand, Maria Celeste Lechner, Esther van Lieshout, Stephanie J. London, Johannes J. Manni, Christine M. Maugard, Shunji Morita, Valle Nazar-Stewart, Kazumasa Noda, Yoshio Oda, Fritz F. Parl, Roberta Pastorelli, Irene Parsson, Wilbert H.M. Peters, Agneta Rannug, Timothy Rebbeck, Angela Risch, Liliane Roelandt, Marjorie Romkes, David Ryberg, Jan Salagovic, Bernadette Schoket, Janeric Seidegard, Peter G. Shields, Edith Sim, Daniel Sinnett, Richard C. Strange , Isabel Stucker, Haruhiko Sugimura, Jordi To-Figueras, Paolo Vineis, Mimi C. Yu, Emanuela Taioli

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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Abstract

Using the International Project on Genetic Susceptibility to Environmental Carcinogens (GSEC) database containing information on over 15,000 control (noncancer) subjects, the allele and genotype frequencies for many of the more commonly studied metabolic genes (CYP1A1, CYP2E1, CYP2D6, GSTM1, GSTT1, NAT2,
GSTP, and EPHX)
in the human population were
determined. Major and significant differences in these frequencies were observed between Caucasians (n = 12,525), Asians (n = 2,136), and Africans and African Americans (n = 996), and some, but much less, heterogeneity was observed within Caucasian populations from different countries. No differences in allele
frequencies were seen by age, sex, or type of controls (hospital patients versus population controls). No examples of linkage disequilibrium between the different
loci were detected based on comparison of observed and expected frequencies for combinations of specific alleles.
Original languageEnglish
Pages (from-to)1239-1248
JournalCancer Epidemiology Biomarkers & Prevention
Volume10
Issue number12
Publication statusPublished - 1 Dec 2001
Externally publishedYes

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