Metabolic syndrome following hypertensive disorders in pregnancy in a low-resource setting: A cohort study

Salisu M. Ishaku*, Tunau Karima, Khadijat A. Oboirien, Agbo P. Innocent, Oyeneyin Lawal, Tukur Jamilu, Joyce L. Browne, Kayode A. Gbenga, Onyebuchi K. Azubuike, Dattijo M. Lamaran, Aminu M. Baffah, Owa O. Olorunfemi, Odusolu O. Patience, Warren E. Charlotte, Hanifah D. Abubakar, Abdulkarim Musa, Arie Franx, Diederick E. Grobbee

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

9 Citations (Scopus)


Objectives: Hypertensive disorders in pregnancy (HDPs) are associated with risk of future metabolic syndrome. Despite the huge burden of HDPs in sub-Saharan Africa, this association has not been adequately studied in this population. Study design: This was a prospective cohort study on pregnant women recruited between August 2017 - April 2018 and followed up to one year after their deliveries and evaluated for presence of metabolic syndrome at delivery, nine weeks, six months and one year. Main outcome measures: Prevalence of metabolic syndrome Results: A total of 488 pregnant women were included: 410 and 78 with HDPs and normotensive, respectively. None of the normotensive had metabolic syndrome until one year (1.7% = 1 out of 59 observations), while among those with HDPs were 17.4% (71 of 407), 8.7% (23 of 263), 4.7% (11 of 232) and 6.1% (17 of 278), at delivery, nine weeks, six months and one year postpartum, respectively. High BMI and blood pressure were the drivers of metabolic syndrome in this population. The incidence rate in HDPs versus normotensive at one year were, respectively, 57.5/1000 persons’ year (95%CI; 35.8 – 92.6) and 16.9/1000 persons’ years (95%CI; 2.4-118.3), with incidence rate ratio of 3.4/1000 person's years. Only parity significantly predicted the presence of metabolic syndrome at one year [(aOR= 3.26/delivery (95%CI; 1.21-8.79)]. Conclusion: HDPs were associated with a higher incidence of metabolic syndrome up to one year postpartum. Women with HDPs should be routinely screened for metabolic syndrome within the first year postpartum to reduce cardiometabolic risks.

Original languageEnglish
Pages (from-to)129-135
Number of pages7
JournalPregnancy Hypertension
Publication statusPublished - Aug 2021

Bibliographical note

Funding Information:
This work was conducted as part of the Ending Eclampsia project (2014–2019), supported by the US Agency for International Development (USAID), under the terms of cooperative agreement number [USAID APSOAA-14-000048]. This article reflects the views of the authors and does not represent the views of the U.S. Government. Salisu Ishaku was also supported by the UMC Utrecht Global Health Fellowship Program.

Publisher Copyright:
© 2021 The Author(s)


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