Metabolomic Signatures for the Effects of Weight Loss Interventions on Severe Obesity in Children and Adolescents

Min Ji Sohn, Woori Chae, Jae Sung Ko, Joo Youn Cho, Ji Eun Kim, Ji Yeob Choi, Han Byul Jang, Hye Ja Lee, Sang Ick Park, Kyung Hee Park, Peter J. van der Spek, Jin Soo Moon*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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Abstract

Childhood obesity has increased worldwide, and many clinical and public interventions have attempted to reduce morbidity. We aimed to determine the metabolomic signatures associated with weight control interventions in children with obesity. Forty children from the “Intervention for Children and Adolescent Obesity via Activity and Nutrition (ICAAN)” cohort were selected according to intervention responses. Based on changes in body mass index z-scores, 20 were responders and the remaining non-responders. Their serum metabolites were quantitatively analyzed using capillary electrophoresis time-of-flight mass spectrometry at baseline and after 6 and 18 months of intervention. After 18 months of intervention, the metabolite cluster changes in the responders and non-responders showed a difference on the heatmap, but significant metabolites were not clear. However, regardless of the responses, 13 and 49 metabolites were significant in the group of children with obesity intervention at 6 months and 18 months post-intervention compared to baseline. In addition, the top five metabolic pathways (D-glutamine and D-glutamate metabolism; arginine biosynthesis; alanine, aspartate, and glutamate metabolism; TCA cycle; valine, leucine, and isoleucine biosynthesis) including several amino acids in the metabolites of obese children after 18 months were significantly changed. Our study showed significantly different metabolomic profiles based on time post obesity-related intervention. Through this study, we can better understand and predict childhood obesity through metabolite analysis and monitoring.

Original languageEnglish
Article number27
JournalMetabolites
Volume12
Issue number1
DOIs
Publication statusPublished - 30 Dec 2021

Bibliographical note

Funding Information:
Funding: This research was funded by the Korea Disease Control and Prevention Agency, grant numbers 2019-ER6405-00 and 2020-NG-012-00.

Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.

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