Metabolomics in early life and the association with body composition at age 2 years

Inge A.L.P. van Beijsterveldt; Stuart G. Snowden; Pernille Neve Myers; Kirsten S. de Fluiter; Bert van de Heijning; Susanne Brix; Ken K. Ong; David B. Dunger; Anita C.S. Hokken-Koelega; Albert Koulman

doi:10.1111/ijpo.12859

Metabolomics in early life and the association with body composition at age 2 years

Inge A.L.P. van Beijsterveldt, Stuart G. Snowden, Pernille Neve Myers, Kirsten S. de Fluiter, Bert van de Heijning, Susanne Brix, Ken K. Ong, David B. Dunger, Anita C.S. Hokken-Koelega^*, Albert Koulman^*

^*Corresponding author for this work

Pediatrics

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Background and Objectives: Early life is a critical window for adiposity programming. Metabolic-profile in early life may reflect this programming and correlate with later life adiposity. We investigated if metabolic-profile at 3 months of age is predictive for body composition at 2 years and if there are differences between boys and girls and between infant feeding types. Methods: In 318 healthy term-born infants, we determined body composition with skinfold measurements and abdominal ultrasound at 3 months and 2 years of age. High-throughput-metabolic-profiling was performed on 3-month-blood-samples. Using random-forest-machine-learning-models, we studied if the metabolic-profile at 3 months can predict body composition outcomes at 2 years of age. Results: Plasma metabolite-profile at 3 months was found to predict body composition at 2 years, based on truncal: peripheral-fat-skinfold-ratio (T:P-ratio), with a predictive value of 75.8%, sensitivity of 100% and specificity of 50%. Predictive value was higher in boys (Q² = 0.322) than girls (Q² = 0.117). Of the 15 metabolite variables most strongly associated with T:P-ratio, 11 were also associated with visceral fat at 2 years of age. Conclusion: Several plasma metabolites (LysoPC(22:2), dimethylarginine and others) at 3 months associate with body composition outcome at 2 years. These results highlight the importance of the first months of life for adiposity programming.

Original language	English
Article number	e12859
Journal	Pediatric obesity
Volume	17
Issue number	3
Early online date	13 Oct 2021
DOIs	https://doi.org/10.1111/ijpo.12859
Publication status	Published - Mar 2022

Bibliographical note

Funding Information:
This study was funded by the EU Commission to the JPI HDHL program ‘Call III Biomarkers’ for the project: BioFN – Biomarkers for Infant Fat Mass Development and Nutrition (Grant agreement No 696295), administrated in Denmark by Innovation Fund Denmark (grant number 4203‐00005B), Netherlands Organisation for Health Research and Development (ZonMW) (grant number 529051013), in the UK by Biotechnology and Biological Sciences Research Council (BB/P028195/1) and Danone Nutricia Research, The Netherlands (to Rotterdam). AK is supported by the NIHR Cambridge Biomedical Research Centre (146281) and KKO is funded by the Medical Research Council (MC_UU_00006/2). Funding information

Publisher Copyright:
© 2021 The Authors. Pediatric Obesity published by John Wiley & Sons Ltd on behalf of World Obesity Federation.

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Cite this

van Beijsterveldt, I. A. L. P., Snowden, S. G., Myers, P. N., de Fluiter, K. S., van de Heijning, B., Brix, S., Ong, K. K., Dunger, D. B., Hokken-Koelega, A. C. S., & Koulman, A. (2022). Metabolomics in early life and the association with body composition at age 2 years. Pediatric obesity, 17(3), Article e12859. Advance online publication. https://doi.org/10.1111/ijpo.12859

@article{57a75bd7cc6e458cb070beb88d954fe7,

title = "Metabolomics in early life and the association with body composition at age 2 years",

abstract = "Background and Objectives: Early life is a critical window for adiposity programming. Metabolic-profile in early life may reflect this programming and correlate with later life adiposity. We investigated if metabolic-profile at 3 months of age is predictive for body composition at 2 years and if there are differences between boys and girls and between infant feeding types. Methods: In 318 healthy term-born infants, we determined body composition with skinfold measurements and abdominal ultrasound at 3 months and 2 years of age. High-throughput-metabolic-profiling was performed on 3-month-blood-samples. Using random-forest-machine-learning-models, we studied if the metabolic-profile at 3 months can predict body composition outcomes at 2 years of age. Results: Plasma metabolite-profile at 3 months was found to predict body composition at 2 years, based on truncal: peripheral-fat-skinfold-ratio (T:P-ratio), with a predictive value of 75.8%, sensitivity of 100% and specificity of 50%. Predictive value was higher in boys (Q2 = 0.322) than girls (Q2 = 0.117). Of the 15 metabolite variables most strongly associated with T:P-ratio, 11 were also associated with visceral fat at 2 years of age. Conclusion: Several plasma metabolites (LysoPC(22:2), dimethylarginine and others) at 3 months associate with body composition outcome at 2 years. These results highlight the importance of the first months of life for adiposity programming.",

author = "{van Beijsterveldt}, {Inge A.L.P.} and Snowden, {Stuart G.} and Myers, {Pernille Neve} and {de Fluiter}, {Kirsten S.} and {van de Heijning}, Bert and Susanne Brix and Ong, {Ken K.} and Dunger, {David B.} and Hokken-Koelega, {Anita C.S.} and Albert Koulman",

note = "Funding Information: This study was funded by the EU Commission to the JPI HDHL program {\textquoteleft}Call III Biomarkers{\textquoteright} for the project: BioFN – Biomarkers for Infant Fat Mass Development and Nutrition (Grant agreement No 696295), administrated in Denmark by Innovation Fund Denmark (grant number 4203‐00005B), Netherlands Organisation for Health Research and Development (ZonMW) (grant number 529051013), in the UK by Biotechnology and Biological Sciences Research Council (BB/P028195/1) and Danone Nutricia Research, The Netherlands (to Rotterdam). AK is supported by the NIHR Cambridge Biomedical Research Centre (146281) and KKO is funded by the Medical Research Council (MC_UU_00006/2). Funding information Publisher Copyright: {\textcopyright} 2021 The Authors. Pediatric Obesity published by John Wiley & Sons Ltd on behalf of World Obesity Federation.",

year = "2022",

month = mar,

doi = "10.1111/ijpo.12859",

language = "English",

volume = "17",

journal = "Pediatric obesity",

issn = "2047-6302",

publisher = "Wiley-Blackwell for the International Association for the Study of Obesity",

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T1 - Metabolomics in early life and the association with body composition at age 2 years

AU - van Beijsterveldt, Inge A.L.P.

AU - Snowden, Stuart G.

AU - Myers, Pernille Neve

AU - de Fluiter, Kirsten S.

AU - van de Heijning, Bert

AU - Brix, Susanne

AU - Ong, Ken K.

AU - Dunger, David B.

AU - Hokken-Koelega, Anita C.S.

AU - Koulman, Albert

N1 - Funding Information: This study was funded by the EU Commission to the JPI HDHL program ‘Call III Biomarkers’ for the project: BioFN – Biomarkers for Infant Fat Mass Development and Nutrition (Grant agreement No 696295), administrated in Denmark by Innovation Fund Denmark (grant number 4203‐00005B), Netherlands Organisation for Health Research and Development (ZonMW) (grant number 529051013), in the UK by Biotechnology and Biological Sciences Research Council (BB/P028195/1) and Danone Nutricia Research, The Netherlands (to Rotterdam). AK is supported by the NIHR Cambridge Biomedical Research Centre (146281) and KKO is funded by the Medical Research Council (MC_UU_00006/2). Funding information Publisher Copyright: © 2021 The Authors. Pediatric Obesity published by John Wiley & Sons Ltd on behalf of World Obesity Federation.

PY - 2022/3

Y1 - 2022/3

N2 - Background and Objectives: Early life is a critical window for adiposity programming. Metabolic-profile in early life may reflect this programming and correlate with later life adiposity. We investigated if metabolic-profile at 3 months of age is predictive for body composition at 2 years and if there are differences between boys and girls and between infant feeding types. Methods: In 318 healthy term-born infants, we determined body composition with skinfold measurements and abdominal ultrasound at 3 months and 2 years of age. High-throughput-metabolic-profiling was performed on 3-month-blood-samples. Using random-forest-machine-learning-models, we studied if the metabolic-profile at 3 months can predict body composition outcomes at 2 years of age. Results: Plasma metabolite-profile at 3 months was found to predict body composition at 2 years, based on truncal: peripheral-fat-skinfold-ratio (T:P-ratio), with a predictive value of 75.8%, sensitivity of 100% and specificity of 50%. Predictive value was higher in boys (Q2 = 0.322) than girls (Q2 = 0.117). Of the 15 metabolite variables most strongly associated with T:P-ratio, 11 were also associated with visceral fat at 2 years of age. Conclusion: Several plasma metabolites (LysoPC(22:2), dimethylarginine and others) at 3 months associate with body composition outcome at 2 years. These results highlight the importance of the first months of life for adiposity programming.

AB - Background and Objectives: Early life is a critical window for adiposity programming. Metabolic-profile in early life may reflect this programming and correlate with later life adiposity. We investigated if metabolic-profile at 3 months of age is predictive for body composition at 2 years and if there are differences between boys and girls and between infant feeding types. Methods: In 318 healthy term-born infants, we determined body composition with skinfold measurements and abdominal ultrasound at 3 months and 2 years of age. High-throughput-metabolic-profiling was performed on 3-month-blood-samples. Using random-forest-machine-learning-models, we studied if the metabolic-profile at 3 months can predict body composition outcomes at 2 years of age. Results: Plasma metabolite-profile at 3 months was found to predict body composition at 2 years, based on truncal: peripheral-fat-skinfold-ratio (T:P-ratio), with a predictive value of 75.8%, sensitivity of 100% and specificity of 50%. Predictive value was higher in boys (Q2 = 0.322) than girls (Q2 = 0.117). Of the 15 metabolite variables most strongly associated with T:P-ratio, 11 were also associated with visceral fat at 2 years of age. Conclusion: Several plasma metabolites (LysoPC(22:2), dimethylarginine and others) at 3 months associate with body composition outcome at 2 years. These results highlight the importance of the first months of life for adiposity programming.

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DO - 10.1111/ijpo.12859

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C2 - 34644810

AN - SCOPUS:85116912120

SN - 2047-6302

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JO - Pediatric obesity

JF - Pediatric obesity

IS - 3

M1 - e12859

ER -

Metabolomics in early life and the association with body composition at age 2 years

Abstract

Bibliographical note

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