TY - JOUR
T1 - Metallo-ss-lactamase-producing Pseudomonas aeruginosa in the Netherlands: the nationwide emergence of a single sequence type
AU - Bij, Akke
AU - Van der Zwan, D
AU - Peirano, G
AU - Severin, Juliette
AU - Pitout, JDD
AU - van Westreenen, Mireille
AU - Goessens, Wil
PY - 2012
Y1 - 2012
N2 - Clin Microbiol Infect 2012; 18: E369E372 Abstract Recently, the first outbreak of clonally related VIM-2 metallo-beta-lactamase (MBL)-producing Pseudomonas aeruginosa in a Dutch tertiary-care centre was described. Subsequently, a nationwide surveillance study was performed in 2010-2011, which identified the presence of VIM-2 MBL-producing P. aeruginosa in 11 different hospitals. Genotyping by multiple-locus variable-number tandem-repeat analysis (MLVA) showed that the majority of the 82 MBL-producing isolates found belonged to a single MLVA type (n = 70, 85%), identified as ST111 by multilocus sequence typing (MLST). As MBL-producing isolates cause serious infections that are difficult to treat, the presence of clonally related isolates in various hospitals throughout the Netherlands is of nationwide concern.
AB - Clin Microbiol Infect 2012; 18: E369E372 Abstract Recently, the first outbreak of clonally related VIM-2 metallo-beta-lactamase (MBL)-producing Pseudomonas aeruginosa in a Dutch tertiary-care centre was described. Subsequently, a nationwide surveillance study was performed in 2010-2011, which identified the presence of VIM-2 MBL-producing P. aeruginosa in 11 different hospitals. Genotyping by multiple-locus variable-number tandem-repeat analysis (MLVA) showed that the majority of the 82 MBL-producing isolates found belonged to a single MLVA type (n = 70, 85%), identified as ST111 by multilocus sequence typing (MLST). As MBL-producing isolates cause serious infections that are difficult to treat, the presence of clonally related isolates in various hospitals throughout the Netherlands is of nationwide concern.
U2 - 10.1111/j.1469-0691.2012.03969.x
DO - 10.1111/j.1469-0691.2012.03969.x
M3 - Article
C2 - 22805614
SN - 1198-743X
VL - 18
SP - E369-E372
JO - Clinical Microbiology and Infection
JF - Clinical Microbiology and Infection
IS - 9
ER -