Metallo-ss-lactamase-producing Pseudomonas aeruginosa in the Netherlands: the nationwide emergence of a single sequence type

Akke Bij, D Van der Zwan, G Peirano, Juliette Severin, JDD Pitout, Mireille van Westreenen, Wil Goessens

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Abstract

Clin Microbiol Infect 2012; 18: E369E372 Abstract Recently, the first outbreak of clonally related VIM-2 metallo-beta-lactamase (MBL)-producing Pseudomonas aeruginosa in a Dutch tertiary-care centre was described. Subsequently, a nationwide surveillance study was performed in 2010-2011, which identified the presence of VIM-2 MBL-producing P. aeruginosa in 11 different hospitals. Genotyping by multiple-locus variable-number tandem-repeat analysis (MLVA) showed that the majority of the 82 MBL-producing isolates found belonged to a single MLVA type (n = 70, 85%), identified as ST111 by multilocus sequence typing (MLST). As MBL-producing isolates cause serious infections that are difficult to treat, the presence of clonally related isolates in various hospitals throughout the Netherlands is of nationwide concern.
Original languageUndefined/Unknown
Pages (from-to)E369-E372
JournalClinical Microbiology and Infection
Volume18
Issue number9
DOIs
Publication statusPublished - 2012

Research programs

  • EMC MM-04-28-01

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