Methodological challenges and biases in the field of cognitive function among patients with chronic kidney disease

Konstantinos Giannakou*, Aleksandra Golenia, Sophie Liabeuf, Jolanta Malyszko, Francesco Mattace-Raso, Ana Farinha, Goce Spasovski, Gaye Hafez, Andrzej Wiecek, Giovanna Capolongo, Giovambattista Capasso, Ziad A. Massy, Marion Pépin

*Corresponding author for this work

Research output: Contribution to journalShort surveyAcademicpeer-review

1 Citation (Scopus)
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Abstract

Chronic kidney disease (CKD) affects approximately 850 million people globally and is associated with an increased risk of cognitive impairment. The prevalence of cognitive impairment among CKD patients ranges from 30 to 60%, and the link between CKD and cognitive impairment is partially understood. Methodological challenges and biases in studying cognitive function in CKD patients need to be addressed to improve diagnosis, treatment, and management of cognitive impairment in this population. Here, we review the methodological challenges and study design issues, including observational studies’ limitations, internal validity, and different types of bias that can impact the validity of research findings. Understanding the unique challenges and biases associated with studying cognitive function in CKD patients can help to identify potential sources of error and improve the quality of future research, leading to more accurate diagnoses and better treatment plans for CKD patients.

Original languageEnglish
Article number1215583
JournalFrontiers in Medicine
Volume10
DOIs
Publication statusPublished - 9 Aug 2023

Bibliographical note

Funding Information:
This article/publication was based upon work from COST Action CA19127-Cognitive Decline in Nephro-Neurology: European Cooperative Target (CONNECT), supported by COST (European Cooperation in Science and Technology), www.cost.eu . COST (European Cooperation in Science and Technology) is a funding agency for research and innovation networks. Our Actions help connect research initiatives across Europe and enable scientists to grow their ideas by sharing them with their peers. This boosts their research, career, and innovation.

Publisher Copyright:
Copyright © 2023 Giannakou, Golenia, Liabeuf, Malyszko, Mattace-Raso, Farinha, Spasovski, Hafez, Wiecek, Capolongo, Capasso, Massy and Pépin.

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