Methylation matters: FK506 binding protein 51 (FKBP5) methylation moderates the associations of FKBP5 genotype and resistant attachment with stress regulation

Rosa Mulder; Jolien Rijlaarsdam; Pieternel Luijk; Frank Verhulst; Janine Felix; Henning Tiemeier; Marian J.  Bakermans-Kranenburg; Marinus IJzendoorn

doi:10.1017/s095457941700013x

Methylation matters: FK506 binding protein 51 (FKBP5) methylation moderates the associations of FKBP5 genotype and resistant attachment with stress regulation

Rosa Mulder, Jolien Rijlaarsdam, Pieternel Luijk, Frank Verhulst, Janine Felix, Henning Tiemeier, Marian J. Bakermans-Kranenburg^*, Marinus IJzendoorn^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

The parent–child attachment relationship plays an important role in the development of the infant’s stress regulation system. However, genetic and epigenetic
factors such as FK506 binding protein 51 (FKBP5) genotype and DNA methylation have also been associated with hypothalamus–pituitary–adrenal
axis functioning. In the current study, we examined how parent–child dyadic regulation works in concert with genetic and epigenetic aspects of stress
regulation. We study the associations of attachment, extreme maternal insensitivity, FKBP5 single nucleotide polymorphism 1360780, and FKBP5
methylation, with cortisol reactivity to the Strange Situation Procedure in 298 14-month-old infants. The results indicate that FKBP5 methylation moderates
the associations of FKBP5 genotype and resistant attachment with cortisol reactivity. We conclude that the inclusion of epigenetics in the field of
developmental psychopathology may lead to a more precise picture of the interplay between genetic makeup and parenting in shaping stress reactivity.

Original language	English
Pages (from-to)	491-503
Number of pages	13
Journal	Development & Psychopathology
Volume	29
Issue number	2
DOIs	https://doi.org/10.1017/s095457941700013x
Publication status	Published - 12 Apr 2017

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EMC MM-04-54-08-A
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methylation_matters_fk506_binding_protein_51_fkbp5_methylation_moderates_the_associations_of_fkbp5_genotype_and_resistant_attachment_with_stress_regulation.pdfFinal published version, 235 KBLicence: Article 25fa Dutch Copyright Act

http://hdl.handle.net/1765/99288

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Mulder, R., Rijlaarsdam, J., Luijk, P., Verhulst, F., Felix, J., Tiemeier, H., Bakermans-Kranenburg, M. J., & IJzendoorn, M. (2017). Methylation matters: FK506 binding protein 51 (FKBP5) methylation moderates the associations of FKBP5 genotype and resistant attachment with stress regulation. Development & Psychopathology, 29(2), 491-503. https://doi.org/10.1017/s095457941700013x

@article{5d94d549ee4b458e849d52aea85e86c9,

title = "Methylation matters: FK506 binding protein 51 (FKBP5) methylation moderates the associations of FKBP5 genotype and resistant attachment with stress regulation",

abstract = "The parent–child attachment relationship plays an important role in the development of the infant{\textquoteright}s stress regulation system. However, genetic and epigeneticfactors such as FK506 binding protein 51 (FKBP5) genotype and DNA methylation have also been associated with hypothalamus–pituitary–adrenalaxis functioning. In the current study, we examined how parent–child dyadic regulation works in concert with genetic and epigenetic aspects of stressregulation. We study the associations of attachment, extreme maternal insensitivity, FKBP5 single nucleotide polymorphism 1360780, and FKBP5methylation, with cortisol reactivity to the Strange Situation Procedure in 298 14-month-old infants. The results indicate that FKBP5 methylation moderatesthe associations of FKBP5 genotype and resistant attachment with cortisol reactivity. We conclude that the inclusion of epigenetics in the field ofdevelopmental psychopathology may lead to a more precise picture of the interplay between genetic makeup and parenting in shaping stress reactivity.",

author = "Rosa Mulder and Jolien Rijlaarsdam and Pieternel Luijk and Frank Verhulst and Janine Felix and Henning Tiemeier and Bakermans-Kranenburg, {Marian J.} and Marinus IJzendoorn",

year = "2017",

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doi = "10.1017/s095457941700013x",

language = "English",

volume = "29",

pages = "491--503",

journal = "Development & Psychopathology",

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publisher = "Cambridge University Press",

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Mulder, R, Rijlaarsdam, J, Luijk, P, Verhulst, F, Felix, J , Tiemeier, H, Bakermans-Kranenburg, MJ & IJzendoorn, M 2017, 'Methylation matters: FK506 binding protein 51 (FKBP5) methylation moderates the associations of FKBP5 genotype and resistant attachment with stress regulation', Development & Psychopathology, vol. 29, no. 2, pp. 491-503. https://doi.org/10.1017/s095457941700013x

Methylation matters: FK506 binding protein 51 (FKBP5) methylation moderates the associations of FKBP5 genotype and resistant attachment with stress regulation. / Mulder, Rosa; Rijlaarsdam, Jolien; Luijk, Pieternel et al.
In: Development & Psychopathology, Vol. 29, No. 2, 12.04.2017, p. 491-503.

Research output: Contribution to journal › Article › Academic › peer-review

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T1 - Methylation matters

T2 - FK506 binding protein 51 (FKBP5) methylation moderates the associations of FKBP5 genotype and resistant attachment with stress regulation

AU - Mulder, Rosa

AU - Rijlaarsdam, Jolien

AU - Luijk, Pieternel

AU - Verhulst, Frank

AU - Felix, Janine

AU - Tiemeier, Henning

AU - Bakermans-Kranenburg, Marian J.

AU - IJzendoorn, Marinus

PY - 2017/4/12

Y1 - 2017/4/12

N2 - The parent–child attachment relationship plays an important role in the development of the infant’s stress regulation system. However, genetic and epigeneticfactors such as FK506 binding protein 51 (FKBP5) genotype and DNA methylation have also been associated with hypothalamus–pituitary–adrenalaxis functioning. In the current study, we examined how parent–child dyadic regulation works in concert with genetic and epigenetic aspects of stressregulation. We study the associations of attachment, extreme maternal insensitivity, FKBP5 single nucleotide polymorphism 1360780, and FKBP5methylation, with cortisol reactivity to the Strange Situation Procedure in 298 14-month-old infants. The results indicate that FKBP5 methylation moderatesthe associations of FKBP5 genotype and resistant attachment with cortisol reactivity. We conclude that the inclusion of epigenetics in the field ofdevelopmental psychopathology may lead to a more precise picture of the interplay between genetic makeup and parenting in shaping stress reactivity.

AB - The parent–child attachment relationship plays an important role in the development of the infant’s stress regulation system. However, genetic and epigeneticfactors such as FK506 binding protein 51 (FKBP5) genotype and DNA methylation have also been associated with hypothalamus–pituitary–adrenalaxis functioning. In the current study, we examined how parent–child dyadic regulation works in concert with genetic and epigenetic aspects of stressregulation. We study the associations of attachment, extreme maternal insensitivity, FKBP5 single nucleotide polymorphism 1360780, and FKBP5methylation, with cortisol reactivity to the Strange Situation Procedure in 298 14-month-old infants. The results indicate that FKBP5 methylation moderatesthe associations of FKBP5 genotype and resistant attachment with cortisol reactivity. We conclude that the inclusion of epigenetics in the field ofdevelopmental psychopathology may lead to a more precise picture of the interplay between genetic makeup and parenting in shaping stress reactivity.

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JO - Development & Psychopathology

JF - Development & Psychopathology

IS - 2

ER -

Methylation matters: FK506 binding protein 51 (FKBP5) methylation moderates the associations of FKBP5 genotype and resistant attachment with stress regulation

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