Methylation status of cKi- ras and MHC genes in rat pituitary glands during aging and tumorigenesis

P. E. Slagboom; A. G. Uitterlinden; J. Vijg

doi:10.1007/BF03323991

Methylation status of cKi- ras and MHC genes in rat pituitary glands during aging and tumorigenesis

P. E. Slagboom^*, A. G. Uitterlinden, J. Vijg

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Methylation patterns of MHC (major histocompatibility complex) class I and vKi-ras (viral Kirsten-ras) homologous sequences in normal and adenomatous rat pituitary glands were studied as a function of age by Southern hybridization analysis using the isoschizomers Hpa II and Msp I. Both MHC class I and vKi-ras homologous sequences were found to be hypomethylated in a number of tumors, compared to normal pituitary gland tissue. However, despite reports indicating a general demethylation in mammalian tissues in relation to donor age, age-related methylation changes in this apparently methylation-unstable and cancer-prone organ were not observed. (Aging 3: 141–146, 1991)

Original language	English
Pages (from-to)	141-146
Number of pages	6
Journal	Aging clinical and experimental research
Volume	3
Issue number	2
DOIs	https://doi.org/10.1007/BF03323991
Publication status	Published - Jun 1991
Externally published	Yes

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title = "Methylation status of cKi- ras and MHC genes in rat pituitary glands during aging and tumorigenesis",

abstract = "Methylation patterns of MHC (major histocompatibility complex) class I and vKi-ras (viral Kirsten-ras) homologous sequences in normal and adenomatous rat pituitary glands were studied as a function of age by Southern hybridization analysis using the isoschizomers Hpa II and Msp I. Both MHC class I and vKi-ras homologous sequences were found to be hypomethylated in a number of tumors, compared to normal pituitary gland tissue. However, despite reports indicating a general demethylation in mammalian tissues in relation to donor age, age-related methylation changes in this apparently methylation-unstable and cancer-prone organ were not observed. (Aging 3: 141–146, 1991)",

author = "Slagboom, {P. E.} and Uitterlinden, {A. G.} and J. Vijg",

year = "1991",

month = jun,

doi = "10.1007/BF03323991",

language = "English",

volume = "3",

pages = "141--146",

journal = "Aging clinical and experimental research",

issn = "1594-0667",

publisher = "Springer Science+Business Media",

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TY - JOUR

T1 - Methylation status of cKi- ras and MHC genes in rat pituitary glands during aging and tumorigenesis

AU - Slagboom, P. E.

AU - Uitterlinden, A. G.

AU - Vijg, J.

PY - 1991/6

Y1 - 1991/6

N2 - Methylation patterns of MHC (major histocompatibility complex) class I and vKi-ras (viral Kirsten-ras) homologous sequences in normal and adenomatous rat pituitary glands were studied as a function of age by Southern hybridization analysis using the isoschizomers Hpa II and Msp I. Both MHC class I and vKi-ras homologous sequences were found to be hypomethylated in a number of tumors, compared to normal pituitary gland tissue. However, despite reports indicating a general demethylation in mammalian tissues in relation to donor age, age-related methylation changes in this apparently methylation-unstable and cancer-prone organ were not observed. (Aging 3: 141–146, 1991)

AB - Methylation patterns of MHC (major histocompatibility complex) class I and vKi-ras (viral Kirsten-ras) homologous sequences in normal and adenomatous rat pituitary glands were studied as a function of age by Southern hybridization analysis using the isoschizomers Hpa II and Msp I. Both MHC class I and vKi-ras homologous sequences were found to be hypomethylated in a number of tumors, compared to normal pituitary gland tissue. However, despite reports indicating a general demethylation in mammalian tissues in relation to donor age, age-related methylation changes in this apparently methylation-unstable and cancer-prone organ were not observed. (Aging 3: 141–146, 1991)

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DO - 10.1007/BF03323991

M3 - Article

C2 - 1911902

AN - SCOPUS:0025916065

SN - 1594-0667

VL - 3

SP - 141

EP - 146

JO - Aging clinical and experimental research

JF - Aging clinical and experimental research

IS - 2

ER -

Methylation status of cKi- ras and MHC genes in rat pituitary glands during aging and tumorigenesis

Abstract

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