Microbiome measurement: Possibilities and pitfalls

Djawad Radjabzadeh, André G. Uitterlinden, Robert Kraaij*

*Corresponding author for this work

Research output: Contribution to journalReview articleAcademicpeer-review

7 Citations (Scopus)


Microbiome research is an emerging field in medical sciences. Several studies have made headways in understanding the influence of microbes on our health and disease states. Further progress in mapping microbiome populations across different body sites and understanding the underlying mechanisms of microbiome-host interactions depends critically on study design, collection protocols, analytical genetic techniques, and reference databases. In particular, a shift has appeared going from small sample collections to large-scale population studies (with extensive phenotypic information including disease status) which calls for some adaptions. In this review we will focus on gut microbiome profiling using the 16S ribosomal RNA approach in the setting of large-scale population studies, and discuss some novel developments.

Original languageEnglish
Pages (from-to)619-623
Number of pages5
JournalBest Practice and Research: Clinical Gastroenterology
Issue number6
Publication statusPublished - Dec 2017

Bibliographical note

Publisher Copyright:
© 2017


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