TY - JOUR
T1 - MicroRNAs relate to early worsening of renal function in patients with acute heart failure
AU - Bruno, Noemi
AU - Ter Maaten, Jozine M.
AU - Ovchinnikova, Ekaterina S.
AU - Vegter, Eline L.
AU - Valente, Mattia A.E.
AU - Van Der Meer, Peter
AU - De Boer, Rudolf A.
AU - Van Der Harst, Pim
AU - Schmitter, Daniela
AU - Metra, Marco
AU - O'Connor, Christopher M.
AU - Ponikowski, Piotr
AU - Teerlink, John R.
AU - Cotter, Gad
AU - Davison, Beth
AU - Cleland, John G.
AU - Givertz, Michael M.
AU - Bloomfield, Daniel M.
AU - Dittrich, Howard C.
AU - Pinto, Yigal M.
AU - Van Veldhuisen, Dirk J.
AU - Hillege, Hans L.
AU - Berezikov, Eugene
AU - Voors, Adriaan A.
N1 - Publisher Copyright:
© 2015 Elsevier Ireland Ltd. All rights reserved.
PY - 2016/1/15
Y1 - 2016/1/15
N2 - Background: Deregulation of microRNAs (miRNAs) may be involved in the pathogenesis of heart failure (HF) and renal disease. Our aim is to describe miRNA levels related to early worsening renal function in acute HF patients. Method and results: We studied the association between 12 circulating miRNAs and Worsening Renal Function (WRF; defined as an increase in the serum creatinine level of 0.3 mg per deciliter or more from admission to day 3), absolute change in creatinine and Neutrophil Gelatinase Associated Lipocalin (NGAL) from admission to day 3 in 98 patients hospitalized for acute HF. At baseline, circulating levels of all miRNAs were lower in patients with WRF, with statistically significant decreased levels of miR-199a-3p, miR-423-3p, and miR-let-7i-5p (p-value < 0.05). The increase in creatinine during the first 3 days of hospitalization was significantly associated with lower levels of miR-199a-3p, miR-27a-3p, miR-652-3p, miR-423-5p, and miR-let-7i-5p, while the increase in NGAL was significantly associated with lower levels of miR-18a-5p, miR-106a-5p, miR-223-3p, miR-199a-3p and miR-423-3p. MiR-199a-3p was the strongest predictor of WRF, with an Odds Ratio of 1.48 (1.061-2.065; p-value = 0.021) and a C-index of 0.701. Conclusions: Our results show that the levels of circulating miRNAs at hospital admission for acute HF were consistently lower in patients who developed worsening of renal function. MiR-199a-3p was the best predictor of WRF in these patients.
AB - Background: Deregulation of microRNAs (miRNAs) may be involved in the pathogenesis of heart failure (HF) and renal disease. Our aim is to describe miRNA levels related to early worsening renal function in acute HF patients. Method and results: We studied the association between 12 circulating miRNAs and Worsening Renal Function (WRF; defined as an increase in the serum creatinine level of 0.3 mg per deciliter or more from admission to day 3), absolute change in creatinine and Neutrophil Gelatinase Associated Lipocalin (NGAL) from admission to day 3 in 98 patients hospitalized for acute HF. At baseline, circulating levels of all miRNAs were lower in patients with WRF, with statistically significant decreased levels of miR-199a-3p, miR-423-3p, and miR-let-7i-5p (p-value < 0.05). The increase in creatinine during the first 3 days of hospitalization was significantly associated with lower levels of miR-199a-3p, miR-27a-3p, miR-652-3p, miR-423-5p, and miR-let-7i-5p, while the increase in NGAL was significantly associated with lower levels of miR-18a-5p, miR-106a-5p, miR-223-3p, miR-199a-3p and miR-423-3p. MiR-199a-3p was the strongest predictor of WRF, with an Odds Ratio of 1.48 (1.061-2.065; p-value = 0.021) and a C-index of 0.701. Conclusions: Our results show that the levels of circulating miRNAs at hospital admission for acute HF were consistently lower in patients who developed worsening of renal function. MiR-199a-3p was the best predictor of WRF in these patients.
UR - http://www.scopus.com/inward/record.url?scp=84952690444&partnerID=8YFLogxK
U2 - 10.1016/j.ijcard.2015.10.217
DO - 10.1016/j.ijcard.2015.10.217
M3 - Article
C2 - 26569364
AN - SCOPUS:84952690444
SN - 0167-5273
VL - 203
SP - 564
EP - 569
JO - International Journal of Cardiology
JF - International Journal of Cardiology
ER -